Source 1primary paper2022Nature Communications
Toolkit/optoSynC
optoSynC
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
optoSynC is a non-ionic optogenetic silencer that uses light-evoked homo-oligomerization of cryptochrome CRY2 to cluster synaptic vesicles and silence synaptic transmission. It was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
Usefulness & Problems
Why this is useful
optoSynC provides optical suppression of synaptic transmission without relying on ionic conductances, as it is described as a non-ionic optogenetic silencer. Its utility is supported by benchmarking across nematode, fish, and mammalian neuronal preparations.
Source:
optoSynC can inhibit exocytosis for several hours, at very low light intensities
Problem solved
optoSynC addresses the problem of silencing synaptic transmission with light by exploiting synaptic vesicle clustering rather than ion flux. The supplied evidence supports this specific use case but does not provide further detail on comparative performance or target contexts.
Problem links
Need precise spatiotemporal control with light input
DerivedoptoSynC is a light-controlled, non-ionic optogenetic silencer that uses CRY2 homo-oligomerization to cluster synaptic vesicles and thereby silence synaptic transmission. It was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A composed arrangement of multiple parts that instantiates one or more mechanisms.
Mechanisms
light-evoked homo-oligomerizationlight-evoked homo-oligomerizationOligomerizationOligomerizationsynaptic vesicle clusteringsynaptic vesicle clusteringTechniques
No technique tags yet.
Target processes
No target processes tagged yet.
Input: Light
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationimplementation constraint: multi component delivery burdenimplementation constraint: spectral hardware requirementoperating role: actuatorswitch architecture: multi component
Implementation requires a CRY2-based optogenetic construct because the silencing mechanism is explicitly attributed to cryptochrome CRY2 homo-oligomerization. The evidence indicates use in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons, but it does not report expression strategy, fusion partners, cofactors, or illumination parameters.
The provided evidence does not specify activation wavelength, kinetics, reversibility metrics, construct architecture, or quantitative silencing performance. Independent replication is not shown in the supplied material, and validation details beyond the named systems are absent.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
duration of exocytosis inhibition several hourslight intensity requirement very low light intensities
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
tau off 6.5 mintau on 7.2 s
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
exocytosis inhibition duration several hourslight intensity very low
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
locomotion silencing tau on 15 srecovery tau off after light-off 10 min
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
synaptic vesicle clustering time 25 s
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
Approval Evidence
1 source11 linked approval claimsfirst-pass slug optosync
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs). We benchmark this tool, optoSynC
Source:
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs). We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
Source:
benchmark scopesupports
optoSynC was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
We benchmark this tool, optoSynC, in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons.
Source:
classificationsupports
optoSynC is a highly efficient non-ionic optogenetic silencer.
optoSynC is a highly efficient, ‘non-ionic’ optogenetic silencer
Source:
functional effectsupports
optoSynC can inhibit exocytosis for several hours at very low light intensities.
optoSynC can inhibit exocytosis for several hours, at very low light intensities
Source:
kineticssupports
optoSynC-induced locomotion silencing occurs with tau_on of about 7.2 seconds and recovery after light-off with tau_off of about 6.5 minutes.
Locomotion silencing occurs with tauon ~7.2 s and recovers with tauoff ~6.5 min after light-off.
Source:
mechanismsupports
optoSynC uses light-evoked homo-oligomerization of CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
Source:
mechanismsupports
optoSynC uses light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission by clustering synaptic vesicles.
Here, we use light-evoked homo-oligomerization of cryptochrome CRY2 to silence synaptic transmission, by clustering synaptic vesicles (SVs).
Source:
performancesupports
optoSynC can inhibit exocytosis for several hours at very low light intensities.
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
Source:
performancesupports
optoSynC causes rapid locomotion silencing with an activation time constant of approximately 15 seconds and recovery after light-off with a time constant of approximately 10 minutes.
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
Source:
performancesupports
optoSynC clusters synaptic vesicles within 25 seconds.
optoSynC clusters SVs within 25 s
Source:
specificitysupports
optoSynC does not affect ion currents, biochemistry, or synaptic proteins.
does not affect ion currents, biochemistry or synaptic proteins
Source:
structural observationsupports
optoSynC clusters synaptic vesicles, observable by electron microscopy.
optoSynC clusters SVs, observable by electron microscopy.
Source:
Comparisons
Source-backed strengths
The source describes optoSynC as highly efficient and based on light-evoked CRY2 homo-oligomerization to silence synaptic transmission through synaptic vesicle clustering. It was benchmarked in Caenorhabditis elegans, zebrafish, and murine hippocampal neurons, indicating validation across multiple model systems.
Source:
Further, optoSynC can inhibit exocytosis for several hours, at very low light intensities.
Source:
Locomotion silencing is rapid (tau on ∼15 s) and recovers quickly (tau off ∼10 min) after light-off.
Source:
optoSynC clusters SVs within 25 s
Compared with AQTrip EL222 variant
optoSynC and AQTrip EL222 variant address a similar problem space.
Shared frame: same top-level item type; shared mechanisms: oligomerization; same primary input modality: light
Compared with CRY2clust
optoSynC and CRY2clust address a similar problem space.
Shared frame: same top-level item type; shared mechanisms: oligomerization; same primary input modality: light
Compared with OptoLoop
optoSynC and OptoLoop address a similar problem space.
Shared frame: same top-level item type; shared mechanisms: oligomerization; same primary input modality: light
Ranked Citations
- 1.