Source 1review2018The Annual Review of Pharmacology and Toxicology
Toolkit/organoids
organoids
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Today, organoids derived from either adult stem cells or pluripotent stem cells can be grown to resemble various organs. As they are similar to their original organs, organoids hold great promise for use in medical research and the development of new treatments.
Usefulness & Problems
Why this is useful
Organoids are stem-cell-derived 3D organ-like models that can be grown to resemble various organs. The review frames them as a current organoid technology platform for research and treatment development.; medical research; disease modeling; drug development; personalized treatment; regenerative medicine
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Organoids are stem-cell-derived 3D organ-like models that can be grown to resemble various organs. The review frames them as a current organoid technology platform for research and treatment development.
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medical research
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disease modeling
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drug development
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personalized treatment
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regenerative medicine
Problem solved
They provide organ-resembling models for basic research, disease modeling, drug development, personalized treatment, and regenerative medicine. The review also notes clinical use enabling personalized medicine for inflammatory bowel disease.; providing organ-like in vitro models derived from stem cells; supporting research and treatment-development applications with models that resemble original organs
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They provide organ-resembling models for basic research, disease modeling, drug development, personalized treatment, and regenerative medicine. The review also notes clinical use enabling personalized medicine for inflammatory bowel disease.
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providing organ-like in vitro models derived from stem cells
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supporting research and treatment-development applications with models that resemble original organs
Problem links
providing organ-like in vitro models derived from stem cells
LiteratureThey provide organ-resembling models for basic research, disease modeling, drug development, personalized treatment, and regenerative medicine. The review also notes clinical use enabling personalized medicine for inflammatory bowel disease.
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They provide organ-resembling models for basic research, disease modeling, drug development, personalized treatment, and regenerative medicine. The review also notes clinical use enabling personalized medicine for inflammatory bowel disease.
supporting research and treatment-development applications with models that resemble original organs
LiteratureThey provide organ-resembling models for basic research, disease modeling, drug development, personalized treatment, and regenerative medicine. The review also notes clinical use enabling personalized medicine for inflammatory bowel disease.
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They provide organ-resembling models for basic research, disease modeling, drug development, personalized treatment, and regenerative medicine. The review also notes clinical use enabling personalized medicine for inflammatory bowel disease.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A reusable architecture pattern for arranging parts into an engineered system.
Techniques
No technique tags yet.
Target processes
No target processes tagged yet.
Input: Chemical
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: actuator
The abstract states that organoids are derived from either adult stem cells or pluripotent stem cells. No additional culture components or assay requirements are specified in the provided text.; requires derivation from adult stem cells or pluripotent stem cells
Independent follow-up evidence is still limited. Validation breadth across biological contexts is still narrow. Independent reuse still looks limited, so the evidence base may be fragile. No canonical validation observations are stored yet, so context-specific performance remains under-specified.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Because organoids are similar to their original organs, they hold promise for medical research and the development of new treatments.
Organoids derived from adult stem cells or pluripotent stem cells can be grown to resemble various organs.
Organoids have already been utilized in the clinic, enabling personalized medicine for inflammatory bowel disease.
The review summarizes applications of organoids in basic research, disease modeling, drug development, personalized treatment, and regenerative medicine.
Approval Evidence
1 source4 linked approval claimsfirst-pass slug organoids
Today, organoids derived from either adult stem cells or pluripotent stem cells can be grown to resemble various organs. As they are similar to their original organs, organoids hold great promise for use in medical research and the development of new treatments.
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application summarysupports
Because organoids are similar to their original organs, they hold promise for medical research and the development of new treatments.
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capability summarysupports
Organoids derived from adult stem cells or pluripotent stem cells can be grown to resemble various organs.
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clinical translation summarysupports
Organoids have already been utilized in the clinic, enabling personalized medicine for inflammatory bowel disease.
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review scope summarysupports
The review summarizes applications of organoids in basic research, disease modeling, drug development, personalized treatment, and regenerative medicine.
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Comparisons
Source-stated alternatives
The provided abstract does not explicitly discuss alternative model systems.
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The provided abstract does not explicitly discuss alternative model systems.
Source-backed strengths
can be grown to resemble various organs; similar to their original organs; already utilized in the clinic for personalized medicine in inflammatory bowel disease
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can be grown to resemble various organs
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similar to their original organs
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already utilized in the clinic for personalized medicine in inflammatory bowel disease
Compared with bacterial degrons
organoids and bacterial degrons address a similar problem space.
Shared frame: same top-level item type; same primary input modality: chemical
Compared with hemisynthetic thiostrepton analogues
organoids and hemisynthetic thiostrepton analogues address a similar problem space.
Shared frame: same top-level item type; same primary input modality: chemical
Compared with rM3Ds
organoids and rM3Ds address a similar problem space.
Shared frame: same top-level item type; same primary input modality: chemical
Ranked Citations
- 1.