Source 1review2019Current Opinion in Structural Biology
Toolkit/pdDronpa
pdDronpa
Taxonomy: Mechanism Branch / Component. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
The supplied web research summary identifies pdDronpa as a photodissociable dimeric Dronpa component used to cage and uncage protein activity in photoswitchable kinases.
Usefulness & Problems
No literature-backed usefulness or problem-fit explainer has been materialized for this record yet.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Component: A low-level protein part used inside a larger architecture that realizes a mechanism.
Techniques
Computational DesignTarget processes
signalingInput: Light
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
iLID is a LOV2-based light-induced dimerization system that controls localization and activity through light-driven conformational exposure of an embedded peptide.
LOVTRAP is a reversible photoinduced dissociation system that uses state-selective binding to LOV2 for sequestration and release.
pdDronpa can be used as a photodissociable component to cage and uncage protein activity in direct conformational control designs.
Approval Evidence
1 source1 linked approval claimfirst-pass slug pddronpa
The supplied web research summary identifies pdDronpa as a photodissociable dimeric Dronpa component used to cage and uncage protein activity in photoswitchable kinases.
Source:
tool functionsupports
pdDronpa can be used as a photodissociable component to cage and uncage protein activity in direct conformational control designs.
Source:
Comparisons
No literature-backed comparison notes have been materialized for this record yet.
Ranked Citations
- 1.