Source 1review2020Chemical Science
Toolkit/photocleavable protecting groups
photocleavable protecting groups
Also known as: photocleavable protecting group
Taxonomy: Mechanism Branch / Component. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Light-based therapeutic and imaging modalities, which emerge in clinical applications, rely on molecular tools, such as photocleavable protecting groups and photoswitches that respond to photonic stimulus and translate it into a biological effect.
Usefulness & Problems
No literature-backed usefulness or problem-fit explainer has been materialized for this record yet.
Published Workflows
Objective: Develop photoresponsive molecular tools suitable for clinical light-based applications.
Why it works: The review states that envisioned clinical scenarios are used to define the properties photoresponsive tools should possess, then discusses optimization of photochemical parameters and pharmacological aspects needed for medical deployment.
light responsivenesstranslation of photonic stimulus into biological effectcontrol of biological functionapplication-scenario-driven property specificationphotochemical parameter optimizationpharmacological property optimization
Stages
- 1.Define clinical application scenarios(decision_gate)
The review first describes envisioned clinical scenarios and uses them to determine what properties photoresponsive tools should have.
Selection: envisioned clinical practice scenarios
- 2.Optimize photochemical parameters(functional_characterization)
The abstract states that optimization of key photochemical parameters is necessary to enable application in the medical field.
Selection: key photochemical performance parameters
- 3.Assess pharmacological suitability(secondary_characterization)
The review gives an outlook on toxicity, solubility, and stability, indicating that these properties are important translational constraints for light-responsive molecules.
Selection: pharmacological aspects relevant to translation
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Component: A low-level protein part used inside a larger architecture that realizes a mechanism.
Mechanisms
PhotocleavageTechniques
No technique tags yet.
Target processes
No target processes tagged yet.
Input: Light
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Emerging clinical light-based therapeutic and imaging modalities rely on photoresponsive molecular tools including photocleavable protecting groups and photoswitches.
Light-based therapeutic and imaging modalities, which emerge in clinical applications, rely on molecular tools, such as photocleavable protecting groups and photoswitches that respond to photonic stimulus and translate it into a biological effect.
Pharmacological aspects including toxicity, solubility, and stability are important considerations for light-responsive molecules intended for medical use.
an outlook is given on pharmacological aspects (toxicity, solubility, and stability) of light-responsive molecules.
Approval Evidence
1 source2 linked approval claimsfirst-pass slug photocleavable-protecting-groups
Light-based therapeutic and imaging modalities, which emerge in clinical applications, rely on molecular tools, such as photocleavable protecting groups and photoswitches that respond to photonic stimulus and translate it into a biological effect.
Source:
review summarysupports
Emerging clinical light-based therapeutic and imaging modalities rely on photoresponsive molecular tools including photocleavable protecting groups and photoswitches.
Light-based therapeutic and imaging modalities, which emerge in clinical applications, rely on molecular tools, such as photocleavable protecting groups and photoswitches that respond to photonic stimulus and translate it into a biological effect.
Source:
translational constraintsupports
Pharmacological aspects including toxicity, solubility, and stability are important considerations for light-responsive molecules intended for medical use.
an outlook is given on pharmacological aspects (toxicity, solubility, and stability) of light-responsive molecules.
Source:
Comparisons
No literature-backed comparison notes have been materialized for this record yet.
Ranked Citations
- 1.