Source 1primary paper2018Handbook of experimental pharmacology
Toolkit/selective CPAR inhibitors
selective CPAR inhibitors
Also known as: compounds that selectively inhibit CPARs
Taxonomy: Technique Branch / Method. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Many tools have been developed to interrogate particular aspects of AMPAR signaling, including compounds that selectively inhibit CPARs, raising exciting translational possibilities.
Usefulness & Problems
Why this is useful
These compounds are described as tools to interrogate particular aspects of AMPAR signaling by selectively inhibiting CPARs.; interrogating particular aspects of AMPAR signaling
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These compounds are described as tools to interrogate particular aspects of AMPAR signaling by selectively inhibiting CPARs.
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interrogating particular aspects of AMPAR signaling
Problem solved
They help isolate the contribution of CPAR-associated signaling and are presented as having translational potential.; providing selective pharmacological interrogation of CPAR-linked AMPAR signaling
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They help isolate the contribution of CPAR-associated signaling and are presented as having translational potential.
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providing selective pharmacological interrogation of CPAR-linked AMPAR signaling
Problem links
providing selective pharmacological interrogation of CPAR-linked AMPAR signaling
LiteratureThey help isolate the contribution of CPAR-associated signaling and are presented as having translational potential.
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They help isolate the contribution of CPAR-associated signaling and are presented as having translational potential.
Taxonomy & Function
Primary hierarchy
Technique Branch
Method: A concrete measurement method used to characterize an engineered system.
Techniques
Functional AssayTarget processes
signalingtranslationImplementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: sensor
Use requires access to compounds that selectively inhibit CPARs and an assay context in which AMPAR signaling can be measured.; requires pharmacological compounds that selectively inhibit CPARs
The abstract does not specify which CPAR inhibitor to use, how selective the compounds are in practice, or which alcohol-related adaptation they best resolve.; no specific compound names or performance details are provided in the abstract
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Transgenic animals and optogenetics have been used to identify AMPAR adaptations in particular cell types and glutamatergic projections.
Compounds that selectively inhibit CPARs have been developed as tools to interrogate AMPAR signaling and may have translational potential.
Approval Evidence
1 source1 linked approval claimfirst-pass slug selective-cpar-inhibitors
Many tools have been developed to interrogate particular aspects of AMPAR signaling, including compounds that selectively inhibit CPARs, raising exciting translational possibilities.
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tool usesupports
Compounds that selectively inhibit CPARs have been developed as tools to interrogate AMPAR signaling and may have translational potential.
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Comparisons
Source-stated alternatives
The abstract also mentions transgenic animals and optogenetics as other approaches used to identify AMPAR adaptations in specific cell types and projections.
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The abstract also mentions transgenic animals and optogenetics as other approaches used to identify AMPAR adaptations in specific cell types and projections.
Source-backed strengths
described as selective for CPARs; noted to raise translational possibilities
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described as selective for CPARs
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noted to raise translational possibilities
Compared with optogenetic functional interrogation
The abstract also mentions transgenic animals and optogenetics as other approaches used to identify AMPAR adaptations in specific cell types and projections.
Shared frame: source-stated alternative in extracted literature
Strengths here: described as selective for CPARs; noted to raise translational possibilities.
Relative tradeoffs: no specific compound names or performance details are provided in the abstract.
Source:
The abstract also mentions transgenic animals and optogenetics as other approaches used to identify AMPAR adaptations in specific cell types and projections.
Compared with optogenetic membrane potential perturbation
The abstract also mentions transgenic animals and optogenetics as other approaches used to identify AMPAR adaptations in specific cell types and projections.
Shared frame: source-stated alternative in extracted literature
Strengths here: described as selective for CPARs; noted to raise translational possibilities.
Relative tradeoffs: no specific compound names or performance details are provided in the abstract.
Source:
The abstract also mentions transgenic animals and optogenetics as other approaches used to identify AMPAR adaptations in specific cell types and projections.
Ranked Citations
- 1.