Source 1primary paper2024Proceedings of the National Academy of Sciences
Toolkit/simple self-assembly model
simple self-assembly model
Taxonomy: Technique Branch / Method. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
The simple self-assembly model is a computational method for active mixtures of microtubules and molecular motors. It captures the extensile-to-contractile transition by representing competition between nematic and polar aligning interactions that drive formation of bundles or asters.
Usefulness & Problems
Why this is useful
This model is useful for interpreting how microscopic interaction rules can produce distinct large-scale organizations in active cytoskeletal mixtures. The available evidence supports its use for describing the transition between extensile and contractile states in microtubule–motor systems.
Problem solved
It addresses the problem of explaining the structural transition from extensile to contractile behavior in active mixtures of microtubules and molecular motors. Specifically, it links this transition to competition between nematic and polar aligning interactions associated with bundle or aster formation.
Taxonomy & Function
Primary hierarchy
Technique Branch
Method: A concrete computational method used to design, rank, or analyze an engineered system.
Mechanisms
competition between nematic and polar aligning interactionscompetition between nematic and polar aligning interactionsself-assemblyself-assemblyTarget processes
No target processes tagged yet.
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: builder
The supplied evidence identifies this tool only as a simple self-assembly model for microtubule and molecular motor mixtures. No details are provided on software, numerical methods, parameterization, input requirements, or code availability.
The provided evidence is limited to a single high-level modeling claim and does not specify equations, parameters, predictive accuracy, or implementation details. No independent replication, benchmarking against alternative models, or validation across multiple experimental systems is described in the supplied evidence.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
A simple self-assembly model captures the extensile-to-contractile transition by competition between nematic and polar aligning interactions that form bundles or asters.
The extensile-to-contractile transition is well captured by a simple self-assembly model where nematic and polar aligning interactions compete to form either bundles or asters.
A simple self-assembly model captures the extensile-to-contractile transition by competition between nematic and polar aligning interactions that form bundles or asters.
The extensile-to-contractile transition is well captured by a simple self-assembly model where nematic and polar aligning interactions compete to form either bundles or asters.
A simple self-assembly model captures the extensile-to-contractile transition by competition between nematic and polar aligning interactions that form bundles or asters.
The extensile-to-contractile transition is well captured by a simple self-assembly model where nematic and polar aligning interactions compete to form either bundles or asters.
A simple self-assembly model captures the extensile-to-contractile transition by competition between nematic and polar aligning interactions that form bundles or asters.
The extensile-to-contractile transition is well captured by a simple self-assembly model where nematic and polar aligning interactions compete to form either bundles or asters.
A simple self-assembly model captures the extensile-to-contractile transition by competition between nematic and polar aligning interactions that form bundles or asters.
The extensile-to-contractile transition is well captured by a simple self-assembly model where nematic and polar aligning interactions compete to form either bundles or asters.
A simple self-assembly model captures the extensile-to-contractile transition by competition between nematic and polar aligning interactions that form bundles or asters.
The extensile-to-contractile transition is well captured by a simple self-assembly model where nematic and polar aligning interactions compete to form either bundles or asters.
A simple self-assembly model captures the extensile-to-contractile transition by competition between nematic and polar aligning interactions that form bundles or asters.
The extensile-to-contractile transition is well captured by a simple self-assembly model where nematic and polar aligning interactions compete to form either bundles or asters.
A simple self-assembly model captures the extensile-to-contractile transition by competition between nematic and polar aligning interactions that form bundles or asters.
The extensile-to-contractile transition is well captured by a simple self-assembly model where nematic and polar aligning interactions compete to form either bundles or asters.
A simple self-assembly model captures the extensile-to-contractile transition by competition between nematic and polar aligning interactions that form bundles or asters.
The extensile-to-contractile transition is well captured by a simple self-assembly model where nematic and polar aligning interactions compete to form either bundles or asters.
A simple self-assembly model captures the extensile-to-contractile transition by competition between nematic and polar aligning interactions that form bundles or asters.
The extensile-to-contractile transition is well captured by a simple self-assembly model where nematic and polar aligning interactions compete to form either bundles or asters.
A simple self-assembly model captures the extensile-to-contractile transition by competition between nematic and polar aligning interactions that form bundles or asters.
The extensile-to-contractile transition is well captured by a simple self-assembly model where nematic and polar aligning interactions compete to form either bundles or asters.
A simple self-assembly model captures the extensile-to-contractile transition by competition between nematic and polar aligning interactions that form bundles or asters.
The extensile-to-contractile transition is well captured by a simple self-assembly model where nematic and polar aligning interactions compete to form either bundles or asters.
A simple self-assembly model captures the extensile-to-contractile transition by competition between nematic and polar aligning interactions that form bundles or asters.
The extensile-to-contractile transition is well captured by a simple self-assembly model where nematic and polar aligning interactions compete to form either bundles or asters.
A simple self-assembly model captures the extensile-to-contractile transition by competition between nematic and polar aligning interactions that form bundles or asters.
The extensile-to-contractile transition is well captured by a simple self-assembly model where nematic and polar aligning interactions compete to form either bundles or asters.
A simple self-assembly model captures the extensile-to-contractile transition by competition between nematic and polar aligning interactions that form bundles or asters.
The extensile-to-contractile transition is well captured by a simple self-assembly model where nematic and polar aligning interactions compete to form either bundles or asters.
A simple self-assembly model captures the extensile-to-contractile transition by competition between nematic and polar aligning interactions that form bundles or asters.
The extensile-to-contractile transition is well captured by a simple self-assembly model where nematic and polar aligning interactions compete to form either bundles or asters.
A simple self-assembly model captures the extensile-to-contractile transition by competition between nematic and polar aligning interactions that form bundles or asters.
The extensile-to-contractile transition is well captured by a simple self-assembly model where nematic and polar aligning interactions compete to form either bundles or asters.
Approval Evidence
1 source1 linked approval claimfirst-pass slug simple-self-assembly-model
The extensile-to-contractile transition is well captured by a simple self-assembly model
Source:
modeling resultsupports
A simple self-assembly model captures the extensile-to-contractile transition by competition between nematic and polar aligning interactions that form bundles or asters.
The extensile-to-contractile transition is well captured by a simple self-assembly model where nematic and polar aligning interactions compete to form either bundles or asters.
Source:
Comparisons
Source-backed strengths
The reported strength is that the extensile-to-contractile transition is well captured by this simple self-assembly model. The source also attributes mechanistic interpretability to the model because the transition is framed in terms of competing nematic and polar alignment interactions.
Compared with free-energy calculations
simple self-assembly model and free-energy calculations address a similar problem space.
Shared frame: same top-level item type
Compared with mathematical model
simple self-assembly model and mathematical model address a similar problem space.
Shared frame: same top-level item type
Strengths here: looks easier to implement in practice.
Compared with SwiftLib
simple self-assembly model and SwiftLib address a similar problem space.
Shared frame: same top-level item type
Ranked Citations
- 1.