Source 1primary paper2023PNAS Nexus
Toolkit/single-headed kinesin molecular motors with optically enhanced clustering
single-headed kinesin molecular motors with optically enhanced clustering
Also known as: optically controlled clusters
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Single-headed kinesin molecular motors with optically enhanced clustering are engineered motors for microtubule-based active fluids that allow light-dependent control of extensile active stress. In the reported system, they support precise and repeatable spatiotemporal patterning of activity and rapid, reversible switching between flowing and quiescent states.
Usefulness & Problems
Why this is useful
This tool is useful for externally controlling the mechanical state of microtubule-based active fluids with light. The reported behavior enables spatial and temporal regulation of extensile stresses and, when combined with conventional kinesin motors, one-time switching from contractile to extensile active stresses.
Source:
We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses.
Problem solved
It addresses the problem of achieving precise, repeatable spatiotemporal control over active stress states in microtubule-based active matter. The source specifically supports control of extensile stresses and switching between dynamic flowing and quiescent states.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A reusable architecture pattern for arranging parts into an engineered system.
Mechanisms
light-controlled switching of active stress statelight-controlled switching of active stress stateoptically enhanced clusteringoptically enhanced clusteringTarget processes
No target processes tagged yet.
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: builder
The available evidence indicates that the tool consists of designed single-headed kinesin motors with optically enhanced clustering used in microtubule-based active fluids. Practical details such as construct composition, expression or purification strategy, cofactors, and illumination parameters are not provided in the supplied evidence.
The supplied evidence does not specify the molecular photosensory module, illumination wavelength, clustering domain architecture, or quantitative performance metrics. Validation is only described in the context of microtubule-based active fluids, so broader applicability to cells or other cytoskeletal systems is not established here.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Single-headed kinesin molecular motors with optically enhanced clustering enable precise and repeatable spatial and temporal control of extensile active stresses.
We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses.
Single-headed kinesin molecular motors with optically enhanced clustering enable precise and repeatable spatial and temporal control of extensile active stresses.
We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses.
Single-headed kinesin molecular motors with optically enhanced clustering enable precise and repeatable spatial and temporal control of extensile active stresses.
We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses.
Single-headed kinesin molecular motors with optically enhanced clustering enable precise and repeatable spatial and temporal control of extensile active stresses.
We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses.
Single-headed kinesin molecular motors with optically enhanced clustering enable precise and repeatable spatial and temporal control of extensile active stresses.
We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses.
Single-headed kinesin molecular motors with optically enhanced clustering enable precise and repeatable spatial and temporal control of extensile active stresses.
We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses.
Single-headed kinesin molecular motors with optically enhanced clustering enable precise and repeatable spatial and temporal control of extensile active stresses.
We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses.
Single-headed kinesin molecular motors with optically enhanced clustering enable precise and repeatable spatial and temporal control of extensile active stresses.
We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses.
Single-headed kinesin molecular motors with optically enhanced clustering enable precise and repeatable spatial and temporal control of extensile active stresses.
We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses.
Single-headed kinesin molecular motors with optically enhanced clustering enable precise and repeatable spatial and temporal control of extensile active stresses.
We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses.
Single-headed kinesin molecular motors with optically enhanced clustering enable precise and repeatable spatial and temporal control of extensile active stresses.
We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses.
Single-headed kinesin molecular motors with optically enhanced clustering enable precise and repeatable spatial and temporal control of extensile active stresses.
We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses.
Single-headed kinesin molecular motors with optically enhanced clustering enable precise and repeatable spatial and temporal control of extensile active stresses.
We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses.
Single-headed kinesin molecular motors with optically enhanced clustering enable precise and repeatable spatial and temporal control of extensile active stresses.
We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses.
Single-headed kinesin molecular motors with optically enhanced clustering enable precise and repeatable spatial and temporal control of extensile active stresses.
We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses.
Single-headed kinesin molecular motors with optically enhanced clustering enable precise and repeatable spatial and temporal control of extensile active stresses.
We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses.
Single-headed kinesin molecular motors with optically enhanced clustering enable precise and repeatable spatial and temporal control of extensile active stresses.
We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
These motors enable rapid, reversible switching between flowing and quiescent states.
Such motors enable rapid, reversible switching between flowing and quiescent states.
These motors enable rapid, reversible switching between flowing and quiescent states.
Such motors enable rapid, reversible switching between flowing and quiescent states.
These motors enable rapid, reversible switching between flowing and quiescent states.
Such motors enable rapid, reversible switching between flowing and quiescent states.
These motors enable rapid, reversible switching between flowing and quiescent states.
Such motors enable rapid, reversible switching between flowing and quiescent states.
These motors enable rapid, reversible switching between flowing and quiescent states.
Such motors enable rapid, reversible switching between flowing and quiescent states.
These motors enable rapid, reversible switching between flowing and quiescent states.
Such motors enable rapid, reversible switching between flowing and quiescent states.
These motors enable rapid, reversible switching between flowing and quiescent states.
Such motors enable rapid, reversible switching between flowing and quiescent states.
These motors enable rapid, reversible switching between flowing and quiescent states.
Such motors enable rapid, reversible switching between flowing and quiescent states.
These motors enable rapid, reversible switching between flowing and quiescent states.
Such motors enable rapid, reversible switching between flowing and quiescent states.
These motors enable rapid, reversible switching between flowing and quiescent states.
Such motors enable rapid, reversible switching between flowing and quiescent states.
These motors enable rapid, reversible switching between flowing and quiescent states.
Such motors enable rapid, reversible switching between flowing and quiescent states.
These motors enable rapid, reversible switching between flowing and quiescent states.
Such motors enable rapid, reversible switching between flowing and quiescent states.
These motors enable rapid, reversible switching between flowing and quiescent states.
Such motors enable rapid, reversible switching between flowing and quiescent states.
These motors enable rapid, reversible switching between flowing and quiescent states.
Such motors enable rapid, reversible switching between flowing and quiescent states.
These motors enable rapid, reversible switching between flowing and quiescent states.
Such motors enable rapid, reversible switching between flowing and quiescent states.
These motors enable rapid, reversible switching between flowing and quiescent states.
Such motors enable rapid, reversible switching between flowing and quiescent states.
These motors enable rapid, reversible switching between flowing and quiescent states.
Such motors enable rapid, reversible switching between flowing and quiescent states.
Spatio-temporal patterning of active stress controls the evolution of bend instability in extensile active fluids and determines its critical length dependence.
spatio-temporal patterning of the active stress controls the evolution of the ubiquitous bend instability of extensile active fluids and determines its critical length dependence
Spatio-temporal patterning of active stress controls the evolution of bend instability in extensile active fluids and determines its critical length dependence.
spatio-temporal patterning of the active stress controls the evolution of the ubiquitous bend instability of extensile active fluids and determines its critical length dependence
Spatio-temporal patterning of active stress controls the evolution of bend instability in extensile active fluids and determines its critical length dependence.
spatio-temporal patterning of the active stress controls the evolution of the ubiquitous bend instability of extensile active fluids and determines its critical length dependence
Spatio-temporal patterning of active stress controls the evolution of bend instability in extensile active fluids and determines its critical length dependence.
spatio-temporal patterning of the active stress controls the evolution of the ubiquitous bend instability of extensile active fluids and determines its critical length dependence
Spatio-temporal patterning of active stress controls the evolution of bend instability in extensile active fluids and determines its critical length dependence.
spatio-temporal patterning of the active stress controls the evolution of the ubiquitous bend instability of extensile active fluids and determines its critical length dependence
Spatio-temporal patterning of active stress controls the evolution of bend instability in extensile active fluids and determines its critical length dependence.
spatio-temporal patterning of the active stress controls the evolution of the ubiquitous bend instability of extensile active fluids and determines its critical length dependence
Spatio-temporal patterning of active stress controls the evolution of bend instability in extensile active fluids and determines its critical length dependence.
spatio-temporal patterning of the active stress controls the evolution of the ubiquitous bend instability of extensile active fluids and determines its critical length dependence
Spatio-temporal patterning of active stress controls the evolution of bend instability in extensile active fluids and determines its critical length dependence.
spatio-temporal patterning of the active stress controls the evolution of the ubiquitous bend instability of extensile active fluids and determines its critical length dependence
Spatio-temporal patterning of active stress controls the evolution of bend instability in extensile active fluids and determines its critical length dependence.
spatio-temporal patterning of the active stress controls the evolution of the ubiquitous bend instability of extensile active fluids and determines its critical length dependence
Spatio-temporal patterning of active stress controls the evolution of bend instability in extensile active fluids and determines its critical length dependence.
spatio-temporal patterning of the active stress controls the evolution of the ubiquitous bend instability of extensile active fluids and determines its critical length dependence
Spatio-temporal patterning of active stress controls the evolution of bend instability in extensile active fluids and determines its critical length dependence.
spatio-temporal patterning of the active stress controls the evolution of the ubiquitous bend instability of extensile active fluids and determines its critical length dependence
Spatio-temporal patterning of active stress controls the evolution of bend instability in extensile active fluids and determines its critical length dependence.
spatio-temporal patterning of the active stress controls the evolution of the ubiquitous bend instability of extensile active fluids and determines its critical length dependence
Spatio-temporal patterning of active stress controls the evolution of bend instability in extensile active fluids and determines its critical length dependence.
spatio-temporal patterning of the active stress controls the evolution of the ubiquitous bend instability of extensile active fluids and determines its critical length dependence
Spatio-temporal patterning of active stress controls the evolution of bend instability in extensile active fluids and determines its critical length dependence.
spatio-temporal patterning of the active stress controls the evolution of the ubiquitous bend instability of extensile active fluids and determines its critical length dependence
Spatio-temporal patterning of active stress controls the evolution of bend instability in extensile active fluids and determines its critical length dependence.
spatio-temporal patterning of the active stress controls the evolution of the ubiquitous bend instability of extensile active fluids and determines its critical length dependence
Spatio-temporal patterning of active stress controls the evolution of bend instability in extensile active fluids and determines its critical length dependence.
spatio-temporal patterning of the active stress controls the evolution of the ubiquitous bend instability of extensile active fluids and determines its critical length dependence
Spatio-temporal patterning of active stress controls the evolution of bend instability in extensile active fluids and determines its critical length dependence.
spatio-temporal patterning of the active stress controls the evolution of the ubiquitous bend instability of extensile active fluids and determines its critical length dependence
Approval Evidence
1 source4 linked approval claimsfirst-pass slug single-headed-kinesin-molecular-motors-with-optically-enhanced-clustering
We design single-headed kinesin molecular motors that exhibit optically enhanced clustering
Source:
capabilitysupports
Single-headed kinesin molecular motors with optically enhanced clustering enable precise and repeatable spatial and temporal control of extensile active stresses.
We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses.
Source:
combined usesupports
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses.
Source:
switching behaviorsupports
These motors enable rapid, reversible switching between flowing and quiescent states.
Such motors enable rapid, reversible switching between flowing and quiescent states.
Source:
system effectsupports
Spatio-temporal patterning of active stress controls the evolution of bend instability in extensile active fluids and determines its critical length dependence.
spatio-temporal patterning of the active stress controls the evolution of the ubiquitous bend instability of extensile active fluids and determines its critical length dependence
Source:
Comparisons
Source-backed strengths
Reported strengths are precise and repeatable spatial and temporal control of extensile active stresses and rapid, reversible switching between flowing and quiescent states. The system also supports a combined-use mode in which optically controlled clusters and conventional kinesin motors produce one-time switching from contractile to extensile active stresses.
Compared with CoTV
single-headed kinesin molecular motors with optically enhanced clustering and CoTV address a similar problem space.
Shared frame: same top-level item type
Strengths here: looks easier to implement in practice.
Compared with genome engineering
single-headed kinesin molecular motors with optically enhanced clustering and genome engineering address a similar problem space.
Shared frame: same top-level item type
Compared with light-dependent protein (un)folding reactions
single-headed kinesin molecular motors with optically enhanced clustering and light-dependent protein (un)folding reactions address a similar problem space.
Shared frame: same top-level item type
Strengths here: looks easier to implement in practice.
Ranked Citations
- 1.