Source 1review2016Frontiers in Chemistry
Toolkit/small-molecule aptamers
small-molecule aptamers
Also known as: aptamers interacting with small molecules, small molecule-binding aptamers
Taxonomy: Mechanism Branch / Component. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
This review will give an overview about aptamers interacting with small molecules and their selection.
Usefulness & Problems
Why this is useful
Small-molecule aptamers are presented as nucleic-acid recognition elements that interact with small molecules. The review frames them as tools for detection and quantification.; binding and detecting small molecules; serving as recognition elements in biosensors
Source:
Small-molecule aptamers are presented as nucleic-acid recognition elements that interact with small molecules. The review frames them as tools for detection and quantification.
Source:
binding and detecting small molecules
Source:
serving as recognition elements in biosensors
Problem solved
They address demand for tools that detect and quantify small molecules such as drugs, toxins, and chemicals.; providing tools to detect and quantify small molecules
Source:
They address demand for tools that detect and quantify small molecules such as drugs, toxins, and chemicals.
Source:
providing tools to detect and quantify small molecules
Problem links
providing tools to detect and quantify small molecules
LiteratureThey address demand for tools that detect and quantify small molecules such as drugs, toxins, and chemicals.
Source:
They address demand for tools that detect and quantify small molecules such as drugs, toxins, and chemicals.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Component: A low-level RNA part used inside a larger architecture that realizes a mechanism.
Mechanisms
small-molecule bindingTechniques
Selection / EnrichmentTarget processes
selectionImplementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: sensor
selection of aptamers for small molecules is presented as a key challenge area
The abstract indicates that important problems remain in their use and selection, but does not specify all failure modes in the provided text.; review states there are problems associated with their use
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Small-molecule aptamer-based sensors have reported applications ranging from drinking water contamination detection to RNA imaging.
There is high demand for tools that detect and quantify small molecules.
The review covers advantages, problems, and possible solutions related to using small-molecule aptamers.
Approval Evidence
1 source2 linked approval claimsfirst-pass slug small-molecule-aptamers
This review will give an overview about aptamers interacting with small molecules and their selection.
Source:
field needsupports
There is high demand for tools that detect and quantify small molecules.
Source:
review scope statementsupports
The review covers advantages, problems, and possible solutions related to using small-molecule aptamers.
Source:
Comparisons
Source-stated alternatives
The provided abstract does not explicitly name alternative recognition platforms.
Source:
The provided abstract does not explicitly name alternative recognition platforms.
Source-backed strengths
review states there are advantages associated with their use
Source:
review states there are advantages associated with their use
Compared with companion diagnostics for solid-tumor CAR-T therapy
small-molecule aptamers and companion diagnostics for solid-tumor CAR-T therapy address a similar problem space because they share selection.
Shared frame: shared target processes: selection
small-molecule aptamers and high-throughput drug screening using hPSC-derived cellular models address a similar problem space because they share selection.
Shared frame: shared target processes: selection
Compared with sgRNA
small-molecule aptamers and sgRNA address a similar problem space because they share selection.
Shared frame: same top-level item type; shared target processes: selection
Ranked Citations
- 1.