Source 1primary paper2020Peptide Science
Toolkit/stapled peptides
stapled peptides
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
stapled peptide methodologies have evolved to a point where they can be used with confidence to generate therapeutic leads
Usefulness & Problems
Why this is useful
Stapled peptides are presented as engineered peptide modalities used to inhibit protein-protein interactions. The review frames them as a mature enough approach to generate therapeutic leads.; inhibiting protein-protein interactions; generating therapeutic leads
Source:
Stapled peptides are presented as engineered peptide modalities used to inhibit protein-protein interactions. The review frames them as a mature enough approach to generate therapeutic leads.
Source:
inhibiting protein-protein interactions
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generating therapeutic leads
Problem solved
They are used to target protein-protein interactions and to improve properties relevant to pharmacological performance.; providing peptide-based inhibitors for protein-protein interactions; improving pharmacological profiles of peptide leads
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They are used to target protein-protein interactions and to improve properties relevant to pharmacological performance.
Source:
providing peptide-based inhibitors for protein-protein interactions
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improving pharmacological profiles of peptide leads
Problem links
improving pharmacological profiles of peptide leads
LiteratureThey are used to target protein-protein interactions and to improve properties relevant to pharmacological performance.
Source:
They are used to target protein-protein interactions and to improve properties relevant to pharmacological performance.
providing peptide-based inhibitors for protein-protein interactions
LiteratureThey are used to target protein-protein interactions and to improve properties relevant to pharmacological performance.
Source:
They are used to target protein-protein interactions and to improve properties relevant to pharmacological performance.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A reusable architecture pattern for arranging parts into an engineered system.
Mechanisms
protein-protein interaction inhibitionTechniques
Computational DesignTarget processes
No target processes tagged yet.
Input: Chemical
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: actuator
The abstract indicates that successful use depends on construction methods, design methodologies, and structural analysis of peptide-target complexes.; requires design methodology for construction
The abstract does not specify which protein-protein interaction classes remain difficult or where stapled peptides fail.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
A number of stapled peptide drug candidates had recently entered clinical trials by 2020.
A number of stapled peptide drug candidates have recently entered clinical trials.
Properties contributing to improved pharmacological profiles are an important consideration in stapled peptide design.
discuss properties that contribute towards improved pharmacological profiles
Stapled peptide methodologies have evolved to a point where they can be used with confidence to generate therapeutic leads.
stapled peptide methodologies have evolved to a point where they can be used with confidence to generate therapeutic leads
Approval Evidence
1 source3 linked approval claimsfirst-pass slug stapled-peptides
stapled peptide methodologies have evolved to a point where they can be used with confidence to generate therapeutic leads
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clinical translationsupports
A number of stapled peptide drug candidates had recently entered clinical trials by 2020.
A number of stapled peptide drug candidates have recently entered clinical trials.
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design considerationsupports
Properties contributing to improved pharmacological profiles are an important consideration in stapled peptide design.
discuss properties that contribute towards improved pharmacological profiles
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maturity or readinesssupports
Stapled peptide methodologies have evolved to a point where they can be used with confidence to generate therapeutic leads.
stapled peptide methodologies have evolved to a point where they can be used with confidence to generate therapeutic leads
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Comparisons
Source-stated alternatives
The abstract does not explicitly name alternative inhibitor modalities.
Source:
The abstract does not explicitly name alternative inhibitor modalities.
Source-backed strengths
can be used with confidence to generate therapeutic leads; some drug candidates have entered clinical trials
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can be used with confidence to generate therapeutic leads
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some drug candidates have entered clinical trials
Compared with bacterial degrons
stapled peptides and bacterial degrons address a similar problem space.
Shared frame: same top-level item type; same primary input modality: chemical
stapled peptides and Pyr-NHS-functionalised 3D graphene foam electrode biosensor address a similar problem space.
Shared frame: same top-level item type; same primary input modality: chemical
Compared with rM3Ds
stapled peptides and rM3Ds address a similar problem space.
Shared frame: same top-level item type; same primary input modality: chemical
Ranked Citations
- 1.