Source 1review2022Frontiers in Bioengineering and Biotechnology
Toolkit/stiffness-tunable hydrogel
stiffness-tunable hydrogel
Also known as: hydrogels with a certain stiffness, hydrogels with different stiffness
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Hydrogels have become one of the most important scaffolds for tissue engineering due to their biocompatibility, biodegradability and water solubility. Especially, the stiffness of hydrogels is a key factor... Herein, this review focus on the design of hydrogels with different stiffness and their effects on the behavior of MSCs.
Usefulness & Problems
Why this is useful
A stiffness-tunable hydrogel serves as a tissue-engineering scaffold whose mechanical properties can be varied. The review frames stiffness as a key determinant of downstream cell behavior.; tissue engineering scaffolds; regenerative medicine; probing stiffness-dependent cell behavior
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A stiffness-tunable hydrogel serves as a tissue-engineering scaffold whose mechanical properties can be varied. The review frames stiffness as a key determinant of downstream cell behavior.
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tissue engineering scaffolds
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regenerative medicine
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probing stiffness-dependent cell behavior
Problem solved
It provides a scaffold platform for regenerative medicine while allowing matrix stiffness to be used as a controllable cue. This is useful for studying and influencing tissue-repair-relevant cell responses.; providing scaffold materials for tissue repair; enabling control of matrix stiffness as a design variable
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It provides a scaffold platform for regenerative medicine while allowing matrix stiffness to be used as a controllable cue. This is useful for studying and influencing tissue-repair-relevant cell responses.
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providing scaffold materials for tissue repair
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enabling control of matrix stiffness as a design variable
Problem links
enabling control of matrix stiffness as a design variable
LiteratureIt provides a scaffold platform for regenerative medicine while allowing matrix stiffness to be used as a controllable cue. This is useful for studying and influencing tissue-repair-relevant cell responses.
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It provides a scaffold platform for regenerative medicine while allowing matrix stiffness to be used as a controllable cue. This is useful for studying and influencing tissue-repair-relevant cell responses.
providing scaffold materials for tissue repair
LiteratureIt provides a scaffold platform for regenerative medicine while allowing matrix stiffness to be used as a controllable cue. This is useful for studying and influencing tissue-repair-relevant cell responses.
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It provides a scaffold platform for regenerative medicine while allowing matrix stiffness to be used as a controllable cue. This is useful for studying and influencing tissue-repair-relevant cell responses.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A reusable architecture pattern for arranging parts into an engineered system.
Mechanisms
mechanoregulation of cell behaviorstiffness-dependent modulation of macrophage phenotypestiffness-dependent modulation of mesenchymal stem cell morphology and differentiationTechniques
Computational DesignTarget processes
No target processes tagged yet.
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: actuator
Implementation requires a hydrogel formulation whose stiffness can be designed or adjusted for the intended application. The abstract does not specify particular chemistries, crosslinkers, or fabrication methods.; requires design of hydrogel stiffness appropriate to the intended cell-response or tissue-repair context
The abstract does not show that stiffness alone is sufficient to solve all tissue-repair challenges. It also does not identify a universally optimal stiffness across tissues or cell types.; the abstract does not specify which hydrogel chemistries or stiffness ranges are optimal for particular repair settings
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
The review states that hydrogel stiffness affects macrophage phenotype and discusses how macrophage phenotype changes relate to inflammatory response and tissue repair.
In addition, the effect of hydrogel stiffness on the phenotype of macrophages is introduced, and then the relationship between the phenotype changes of macrophages on inflammatory response and tissue repair is discussed.
Hydrogel stiffness is presented as a key factor influencing mesenchymal stem cell morphology and differentiation.
Especially, the stiffness of hydrogels is a key factor, which influence the morphology of mesenchymal stem cells (MSCs) and their differentiation.
Hydrogels are important scaffolds for tissue engineering because of their biocompatibility, biodegradability, and water solubility.
Hydrogels have become one of the most important scaffolds for tissue engineering due to their biocompatibility, biodegradability and water solubility.
Approval Evidence
1 source3 linked approval claimsfirst-pass slug stiffness-tunable-hydrogel
Hydrogels have become one of the most important scaffolds for tissue engineering due to their biocompatibility, biodegradability and water solubility. Especially, the stiffness of hydrogels is a key factor... Herein, this review focus on the design of hydrogels with different stiffness and their effects on the behavior of MSCs.
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immunomodulation summarysupports
The review states that hydrogel stiffness affects macrophage phenotype and discusses how macrophage phenotype changes relate to inflammatory response and tissue repair.
In addition, the effect of hydrogel stiffness on the phenotype of macrophages is introduced, and then the relationship between the phenotype changes of macrophages on inflammatory response and tissue repair is discussed.
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mechanobiology summarysupports
Hydrogel stiffness is presented as a key factor influencing mesenchymal stem cell morphology and differentiation.
Especially, the stiffness of hydrogels is a key factor, which influence the morphology of mesenchymal stem cells (MSCs) and their differentiation.
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review scope summarysupports
Hydrogels are important scaffolds for tissue engineering because of their biocompatibility, biodegradability, and water solubility.
Hydrogels have become one of the most important scaffolds for tissue engineering due to their biocompatibility, biodegradability and water solubility.
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Comparisons
Source-stated alternatives
The abstract does not explicitly discuss alternative scaffold classes. It only positions hydrogels as an important scaffold type in tissue engineering.
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The abstract does not explicitly discuss alternative scaffold classes. It only positions hydrogels as an important scaffold type in tissue engineering.
Source-backed strengths
biocompatibility; biodegradability; water solubility; stiffness can be designed or tuned
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biocompatibility
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biodegradability
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water solubility
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stiffness can be designed or tuned
Compared with hydrogels
The abstract does not explicitly discuss alternative scaffold classes. It only positions hydrogels as an important scaffold type in tissue engineering.
Shared frame: source-stated alternative in extracted literature
Strengths here: biocompatibility; biodegradability; water solubility.
Relative tradeoffs: the abstract does not specify which hydrogel chemistries or stiffness ranges are optimal for particular repair settings.
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The abstract does not explicitly discuss alternative scaffold classes. It only positions hydrogels as an important scaffold type in tissue engineering.
Ranked Citations
- 1.