Source 1primary paper2011Science
Toolkit/synthetic optogenetic transcription device
synthetic optogenetic transcription device
Also known as: synthetic light-pulse-transcription converters, synthetic signaling cascade
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
The synthetic optogenetic transcription device is a multi-component light-responsive signaling cascade that links melanopsin signal transduction to the nuclear factor of activated T cells (NFAT) control circuit to drive light-inducible transgene expression. It was reported to enable remote regulation of implanted transgenic cells in mice and to enhance blood-glucose homeostasis.
Usefulness & Problems
Why this is useful
This system is useful for remotely controlling transgene expression with light in implanted mammalian cells. The cited study reports control of serum secreted alkaline phosphatase levels by fiber-optic or direct transdermal illumination in mice, indicating utility for noninvasive regulation of therapeutic cell implants.
Source:
In animals harboring intraperitoneal hollow-fiber or subcutaneous implants containing light-inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote-controlled with fiber optics or transdermally regulated through direct illumination.
Source:
we have designed a synthetic signaling cascade enabling light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice
Source:
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
Source:
Light-controlled expression of the glucagon-like peptide 1 was able to attenuate glycemic excursions in type II diabetic mice.
Problem solved
It addresses the problem of coupling an external light input to mammalian transcriptional output through a synthetic signaling pathway. Specifically, it provides a way to convert melanopsin-dependent light sensing into NFAT-mediated transgene expression in vivo.
Source:
In animals harboring intraperitoneal hollow-fiber or subcutaneous implants containing light-inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote-controlled with fiber optics or transdermally regulated through direct illumination.
Source:
Light-controlled expression of the glucagon-like peptide 1 was able to attenuate glycemic excursions in type II diabetic mice.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A composed arrangement of multiple parts that instantiates one or more mechanisms.
Techniques
Computational DesignTarget processes
recombinationsignalingtranscriptionInput: Light
Implementation Constraints
The available evidence indicates a multi-component construct architecture that functionally links melanopsin signal transduction to an NFAT control circuit in transgenic cells. Validation involved implanted light-inducible transgenic cells in mice with stimulation by fiber optics or direct transdermal illumination, but the provided text does not specify construct composition, host cell type, or cofactor requirements.
The supplied evidence does not provide quantitative performance metrics, spectral parameters, kinetics, dynamic range, or leakiness. Independent replication is not documented in the provided material, and mechanistic details beyond melanopsin-to-NFAT coupling are not described here.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Source 2primary paper2011Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Ranked Claims
In mice carrying implants containing light-inducible transgenic cells, serum levels of secreted alkaline phosphatase could be remotely controlled by fiber optics or by direct transdermal illumination.
In animals harboring intraperitoneal hollow-fiber or subcutaneous implants containing light-inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote-controlled with fiber optics or transdermally regulated through direct illumination.
In mice carrying implants containing light-inducible transgenic cells, serum levels of secreted alkaline phosphatase could be remotely controlled by fiber optics or by direct transdermal illumination.
In animals harboring intraperitoneal hollow-fiber or subcutaneous implants containing light-inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote-controlled with fiber optics or transdermally regulated through direct illumination.
In mice carrying implants containing light-inducible transgenic cells, serum levels of secreted alkaline phosphatase could be remotely controlled by fiber optics or by direct transdermal illumination.
In animals harboring intraperitoneal hollow-fiber or subcutaneous implants containing light-inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote-controlled with fiber optics or transdermally regulated through direct illumination.
In mice carrying implants containing light-inducible transgenic cells, serum levels of secreted alkaline phosphatase could be remotely controlled by fiber optics or by direct transdermal illumination.
In animals harboring intraperitoneal hollow-fiber or subcutaneous implants containing light-inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote-controlled with fiber optics or transdermally regulated through direct illumination.
In mice carrying implants containing light-inducible transgenic cells, serum levels of secreted alkaline phosphatase could be remotely controlled by fiber optics or by direct transdermal illumination.
In animals harboring intraperitoneal hollow-fiber or subcutaneous implants containing light-inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote-controlled with fiber optics or transdermally regulated through direct illumination.
In mice carrying implants containing light-inducible transgenic cells, serum levels of secreted alkaline phosphatase could be remotely controlled by fiber optics or by direct transdermal illumination.
In animals harboring intraperitoneal hollow-fiber or subcutaneous implants containing light-inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote-controlled with fiber optics or transdermally regulated through direct illumination.
In mice carrying implants containing light-inducible transgenic cells, serum levels of secreted alkaline phosphatase could be remotely controlled by fiber optics or by direct transdermal illumination.
In animals harboring intraperitoneal hollow-fiber or subcutaneous implants containing light-inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote-controlled with fiber optics or transdermally regulated through direct illumination.
In mice carrying implants containing light-inducible transgenic cells, serum levels of secreted alkaline phosphatase could be remotely controlled by fiber optics or by direct transdermal illumination.
In animals harboring intraperitoneal hollow-fiber or subcutaneous implants containing light-inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote-controlled with fiber optics or transdermally regulated through direct illumination.
In mice carrying implants containing light-inducible transgenic cells, serum levels of secreted alkaline phosphatase could be remotely controlled by fiber optics or by direct transdermal illumination.
In animals harboring intraperitoneal hollow-fiber or subcutaneous implants containing light-inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote-controlled with fiber optics or transdermally regulated through direct illumination.
In mice carrying implants containing light-inducible transgenic cells, serum levels of secreted alkaline phosphatase could be remotely controlled by fiber optics or by direct transdermal illumination.
In animals harboring intraperitoneal hollow-fiber or subcutaneous implants containing light-inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote-controlled with fiber optics or transdermally regulated through direct illumination.
In mice carrying implants containing light-inducible transgenic cells, serum levels of secreted alkaline phosphatase could be remotely controlled by fiber optics or by direct transdermal illumination.
In animals harboring intraperitoneal hollow-fiber or subcutaneous implants containing light-inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote-controlled with fiber optics or transdermally regulated through direct illumination.
In mice carrying implants containing light-inducible transgenic cells, serum levels of secreted alkaline phosphatase could be remotely controlled by fiber optics or by direct transdermal illumination.
In animals harboring intraperitoneal hollow-fiber or subcutaneous implants containing light-inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote-controlled with fiber optics or transdermally regulated through direct illumination.
In mice carrying implants containing light-inducible transgenic cells, serum levels of secreted alkaline phosphatase could be remotely controlled by fiber optics or by direct transdermal illumination.
In animals harboring intraperitoneal hollow-fiber or subcutaneous implants containing light-inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote-controlled with fiber optics or transdermally regulated through direct illumination.
In mice carrying implants containing light-inducible transgenic cells, serum levels of secreted alkaline phosphatase could be remotely controlled by fiber optics or by direct transdermal illumination.
In animals harboring intraperitoneal hollow-fiber or subcutaneous implants containing light-inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote-controlled with fiber optics or transdermally regulated through direct illumination.
The authors designed a synthetic signaling cascade linking melanopsin signal transduction to an NFAT control circuit to enable light-inducible transgene expression.
By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light-inducible transgene expression
The authors designed a synthetic signaling cascade linking melanopsin signal transduction to an NFAT control circuit to enable light-inducible transgene expression.
By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light-inducible transgene expression
The authors designed a synthetic signaling cascade linking melanopsin signal transduction to an NFAT control circuit to enable light-inducible transgene expression.
By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light-inducible transgene expression
The authors designed a synthetic signaling cascade linking melanopsin signal transduction to an NFAT control circuit to enable light-inducible transgene expression.
By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light-inducible transgene expression
The authors designed a synthetic signaling cascade linking melanopsin signal transduction to an NFAT control circuit to enable light-inducible transgene expression.
By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light-inducible transgene expression
The authors designed a synthetic signaling cascade linking melanopsin signal transduction to an NFAT control circuit to enable light-inducible transgene expression.
By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light-inducible transgene expression
The authors designed a synthetic signaling cascade linking melanopsin signal transduction to an NFAT control circuit to enable light-inducible transgene expression.
By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light-inducible transgene expression
The authors designed a synthetic signaling cascade linking melanopsin signal transduction to an NFAT control circuit to enable light-inducible transgene expression.
By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light-inducible transgene expression
The authors designed a synthetic signaling cascade linking melanopsin signal transduction to an NFAT control circuit to enable light-inducible transgene expression.
By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light-inducible transgene expression
The authors designed a synthetic signaling cascade linking melanopsin signal transduction to an NFAT control circuit to enable light-inducible transgene expression.
By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light-inducible transgene expression
The authors designed a synthetic signaling cascade linking melanopsin signal transduction to an NFAT control circuit to enable light-inducible transgene expression.
By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light-inducible transgene expression
The authors designed a synthetic signaling cascade linking melanopsin signal transduction to an NFAT control circuit to enable light-inducible transgene expression.
By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light-inducible transgene expression
The authors designed a synthetic signaling cascade linking melanopsin signal transduction to an NFAT control circuit to enable light-inducible transgene expression.
By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light-inducible transgene expression
The authors designed a synthetic signaling cascade linking melanopsin signal transduction to an NFAT control circuit to enable light-inducible transgene expression.
By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light-inducible transgene expression
The synthetic optogenetic transcription device enables light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.
we have designed a synthetic signaling cascade enabling light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice
The synthetic optogenetic transcription device enables light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.
we have designed a synthetic signaling cascade enabling light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice
The synthetic optogenetic transcription device enables light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.
we have designed a synthetic signaling cascade enabling light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice
The synthetic optogenetic transcription device enables light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.
we have designed a synthetic signaling cascade enabling light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice
The synthetic optogenetic transcription device enables light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.
we have designed a synthetic signaling cascade enabling light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice
The synthetic optogenetic transcription device enables light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.
we have designed a synthetic signaling cascade enabling light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice
The synthetic optogenetic transcription device enables light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.
we have designed a synthetic signaling cascade enabling light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice
The synthetic optogenetic transcription device enables light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.
we have designed a synthetic signaling cascade enabling light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice
The synthetic optogenetic transcription device enables light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.
we have designed a synthetic signaling cascade enabling light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice
The synthetic optogenetic transcription device enables light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.
we have designed a synthetic signaling cascade enabling light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice
The synthetic optogenetic transcription device enables light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.
we have designed a synthetic signaling cascade enabling light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice
The synthetic optogenetic transcription device enables light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.
we have designed a synthetic signaling cascade enabling light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice
The synthetic optogenetic transcription device enables light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.
we have designed a synthetic signaling cascade enabling light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice
The synthetic optogenetic transcription device enables light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.
we have designed a synthetic signaling cascade enabling light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
Light-controlled expression of glucagon-like peptide 1 attenuated glycemic excursions in type II diabetic mice.
Light-controlled expression of the glucagon-like peptide 1 was able to attenuate glycemic excursions in type II diabetic mice.
Light-controlled expression of glucagon-like peptide 1 attenuated glycemic excursions in type II diabetic mice.
Light-controlled expression of the glucagon-like peptide 1 was able to attenuate glycemic excursions in type II diabetic mice.
Light-controlled expression of glucagon-like peptide 1 attenuated glycemic excursions in type II diabetic mice.
Light-controlled expression of the glucagon-like peptide 1 was able to attenuate glycemic excursions in type II diabetic mice.
Light-controlled expression of glucagon-like peptide 1 attenuated glycemic excursions in type II diabetic mice.
Light-controlled expression of the glucagon-like peptide 1 was able to attenuate glycemic excursions in type II diabetic mice.
Light-controlled expression of glucagon-like peptide 1 attenuated glycemic excursions in type II diabetic mice.
Light-controlled expression of the glucagon-like peptide 1 was able to attenuate glycemic excursions in type II diabetic mice.
Light-controlled expression of glucagon-like peptide 1 attenuated glycemic excursions in type II diabetic mice.
Light-controlled expression of the glucagon-like peptide 1 was able to attenuate glycemic excursions in type II diabetic mice.
Light-controlled expression of glucagon-like peptide 1 attenuated glycemic excursions in type II diabetic mice.
Light-controlled expression of the glucagon-like peptide 1 was able to attenuate glycemic excursions in type II diabetic mice.
Light-controlled expression of glucagon-like peptide 1 attenuated glycemic excursions in type II diabetic mice.
Light-controlled expression of the glucagon-like peptide 1 was able to attenuate glycemic excursions in type II diabetic mice.
Light-controlled expression of glucagon-like peptide 1 attenuated glycemic excursions in type II diabetic mice.
Light-controlled expression of the glucagon-like peptide 1 was able to attenuate glycemic excursions in type II diabetic mice.
Light-controlled expression of glucagon-like peptide 1 attenuated glycemic excursions in type II diabetic mice.
Light-controlled expression of the glucagon-like peptide 1 was able to attenuate glycemic excursions in type II diabetic mice.
Light-controlled expression of glucagon-like peptide 1 attenuated glycemic excursions in type II diabetic mice.
Light-controlled expression of the glucagon-like peptide 1 was able to attenuate glycemic excursions in type II diabetic mice.
Light-controlled expression of glucagon-like peptide 1 attenuated glycemic excursions in type II diabetic mice.
Light-controlled expression of the glucagon-like peptide 1 was able to attenuate glycemic excursions in type II diabetic mice.
Light-controlled expression of glucagon-like peptide 1 attenuated glycemic excursions in type II diabetic mice.
Light-controlled expression of the glucagon-like peptide 1 was able to attenuate glycemic excursions in type II diabetic mice.
Light-controlled expression of glucagon-like peptide 1 attenuated glycemic excursions in type II diabetic mice.
Light-controlled expression of the glucagon-like peptide 1 was able to attenuate glycemic excursions in type II diabetic mice.
Approval Evidence
2 sources8 linked approval claimsfirst-pass slug synthetic-optogenetic-transcription-device
By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light-inducible transgene expression
Source:
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
Source:
applicationsupports
In mice carrying implants containing light-inducible transgenic cells, serum levels of secreted alkaline phosphatase could be remotely controlled by fiber optics or by direct transdermal illumination.
In animals harboring intraperitoneal hollow-fiber or subcutaneous implants containing light-inducible transgenic cells, the serum levels of the human glycoprotein secreted alkaline phosphatase could be remote-controlled with fiber optics or transdermally regulated through direct illumination.
Source:
designsupports
The authors designed a synthetic signaling cascade linking melanopsin signal transduction to an NFAT control circuit to enable light-inducible transgene expression.
By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light-inducible transgene expression
Source:
functionsupports
The synthetic optogenetic transcription device enables light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.
we have designed a synthetic signaling cascade enabling light-inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice
Source:
functional effectsupports
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
Source:
functional effectsupports
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
Source:
potential applicationsupports
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Synthetic light-pulse-transcription converters may have applications in therapeutics and protein expression technology.
Source:
reported effectsupports
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice.
Source:
therapeutic effectsupports
Light-controlled expression of glucagon-like peptide 1 attenuated glycemic excursions in type II diabetic mice.
Light-controlled expression of the glucagon-like peptide 1 was able to attenuate glycemic excursions in type II diabetic mice.
Source:
Comparisons
Source-backed strengths
The device was designed as a defined synthetic cascade connecting melanopsin signaling to NFAT-dependent transcription. In mice carrying implants containing light-inducible transgenic cells, serum levels of secreted alkaline phosphatase were remotely controlled by fiber optics or direct transdermal illumination, and the study reports enhanced blood-glucose homeostasis.
Ranked Citations
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