Source 1review2017The Journal of Cell Biology
Toolkit/tension sensors
tension sensors
Taxonomy: Technique Branch / Method. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Tension sensors are assay methods cited as emerging tools for studying branching morphogenesis. In the supplied evidence, they are presented as part of a methodological set that can create new opportunities for future research.
Usefulness & Problems
Why this is useful
These sensors are useful because they are specifically identified as new methodologies for investigating branching morphogenesis, a process that requires coordinated interactions among multiple cell types and the extracellular matrix. Their value is framed in relation to studying dynamic tissue behaviors during branch elongation and tip maturation.
Problem solved
The evidence indicates that tension sensors help address the need for improved methodological access to branching morphogenesis. This is relevant because branching morphogenesis involves coordinated cell and matrix dynamics that are difficult to study with less advanced approaches.
Problem links
Need conditional recombination or state switching
DerivedTension sensors are assay methods cited as emerging tools for studying branching morphogenesis. In the supplied evidence, they are presented as part of a methodological set that can create new opportunities for future research.
Taxonomy & Function
Primary hierarchy
Technique Branch
Method: A concrete measurement method used to characterize an engineered system.
Mechanisms
No mechanism tags yet.
Techniques
Functional AssayTarget processes
recombinationImplementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: sensor
The evidence only states that tension sensors are used as a methodology in the context of branching morphogenesis research. No practical details are provided on construct design, cofactors, imaging requirements, delivery, or expression systems.
The supplied evidence does not specify the molecular design, readout modality, spatial resolution, organism, or validation data for the tension sensors. It also does not document any direct application to recombination despite that listed target process.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.
Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.
Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.
Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.
Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.
Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.
Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.
Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.
Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.
Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.
Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.
Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.
Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.
Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.
Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.
New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.
New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.
New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.
New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.
New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.
New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.
New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
New branches in branching morphogenesis form by budding or clefting.
During branching morphogenesis, new branches form by "budding" or "clefting."
New branches in branching morphogenesis form by budding or clefting.
During branching morphogenesis, new branches form by "budding" or "clefting."
New branches in branching morphogenesis form by budding or clefting.
During branching morphogenesis, new branches form by "budding" or "clefting."
New branches in branching morphogenesis form by budding or clefting.
During branching morphogenesis, new branches form by "budding" or "clefting."
New branches in branching morphogenesis form by budding or clefting.
During branching morphogenesis, new branches form by "budding" or "clefting."
New branches in branching morphogenesis form by budding or clefting.
During branching morphogenesis, new branches form by "budding" or "clefting."
New branches in branching morphogenesis form by budding or clefting.
During branching morphogenesis, new branches form by "budding" or "clefting."
Approval Evidence
1 source5 linked approval claimsfirst-pass slug tension-sensors
New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Source:
biological process summarysupports
Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.
Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Source:
developmental stage summarysupports
Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Source:
mechanism variation summarysupports
Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.
Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Source:
methodology opportunity summarysupports
High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.
New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Source:
process mode summarysupports
New branches in branching morphogenesis form by budding or clefting.
During branching morphogenesis, new branches form by "budding" or "clefting."
Source:
Comparisons
Source-backed strengths
A key strength supported by the evidence is that tension sensors are considered an emerging methodology that expands experimental opportunities in branching morphogenesis research. The cited biological context includes complex events such as cell elongation, intercalation, convergent extension, proliferation, and differentiation during branch elongation and tip maturation.
Compared with barcoded Cre recombinase mRNA barcode platform
tension sensors and barcoded Cre recombinase mRNA barcode platform address a similar problem space because they share recombination.
Shared frame: same top-level item type; shared target processes: recombination
Compared with calcium imaging
tension sensors and calcium imaging address a similar problem space because they share recombination.
Shared frame: same top-level item type; shared target processes: recombination
Relative tradeoffs: appears more independently replicated.
Compared with two-photon excitation microscopy
tension sensors and two-photon excitation microscopy address a similar problem space because they share recombination.
Shared frame: same top-level item type; shared target processes: recombination
Strengths here: looks easier to implement in practice.
Ranked Citations
- 1.