Toolkit/tension sensors

tension sensors

Assay Method·Research·Since 2017

Taxonomy: Technique Branch / Method. Workflows sit above the mechanism and technique branches rather than replacing them.

Summary

Tension sensors are assay methods cited as emerging tools for studying branching morphogenesis. In the supplied evidence, they are presented as part of a methodological set that can create new opportunities for future research.

Usefulness & Problems

Why this is useful

These sensors are useful because they are specifically identified as new methodologies for investigating branching morphogenesis, a process that requires coordinated interactions among multiple cell types and the extracellular matrix. Their value is framed in relation to studying dynamic tissue behaviors during branch elongation and tip maturation.

Problem solved

The evidence indicates that tension sensors help address the need for improved methodological access to branching morphogenesis. This is relevant because branching morphogenesis involves coordinated cell and matrix dynamics that are difficult to study with less advanced approaches.

Problem links

Need conditional recombination or state switching

Derived

Tension sensors are assay methods cited as emerging tools for studying branching morphogenesis. In the supplied evidence, they are presented alongside high-resolution live imaging and force-mapping techniques as methodologies that create new opportunities for future research.

Taxonomy & Function

Primary hierarchy

Technique Branch

Method: A concrete measurement method used to characterize an engineered system.

Mechanisms

No mechanism tags yet.

Target processes

recombination

Implementation Constraints

cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: sensor

The evidence only states that tension sensors are used as a methodology in the context of branching morphogenesis research. No practical details are provided on construct design, cofactors, imaging requirements, delivery, or expression systems.

The supplied evidence does not specify the molecular design, readout modality, spatial resolution, organism, or validation data for the tension sensors. It also does not document any direct application to recombination despite that listed target process.

Validation

Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication

Supporting Sources

Ranked Claims

Claim 1biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 2biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 3biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 4biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 5biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 6biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 7biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 8biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 9biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 10biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 11biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 12biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 13biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 14biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 15biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 16biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 17biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 18biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 19biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 20biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 21biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 22biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 23biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 24biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 25biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 26biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 27biological process summarysupports2017Source 1needs review

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).
Claim 28developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 29developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 30developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 31developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 32developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 33developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 34developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 35developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 36developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 37developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 38developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 39developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 40developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 41developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 42developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 43developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 44developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 45developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 46developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 47developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 48developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 49developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 50developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 51developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 52developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 53developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 54developmental stage summarysupports2017Source 1needs review

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.
Claim 55mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 56mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 57mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 58mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 59mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 60mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 61mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 62mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 63mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 64mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 65mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 66mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 67mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 68mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 69mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 70mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 71mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 72mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 73mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 74mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 75mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 76mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 77mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 78mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 79mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 80mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 81mechanism variation summarysupports2017Source 1needs review

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.
Claim 82methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 83methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 84methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 85methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 86methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 87methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 88methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 89methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 90methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 91methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 92methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 93methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 94methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 95methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 96methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 97methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 98methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 99methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 100methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 101methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 102methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 103methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 104methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 105methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 106methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 107methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 108methodology opportunity summarysupports2017Source 1needs review

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Claim 109process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 110process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 111process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 112process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 113process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 114process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 115process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 116process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 117process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 118process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 119process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 120process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 121process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 122process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 123process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 124process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 125process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 126process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 127process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 128process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 129process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 130process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 131process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 132process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 133process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 134process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."
Claim 135process mode summarysupports2017Source 1needs review

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."

Approval Evidence

1 source5 linked approval claimsfirst-pass slug tension-sensors
New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.

Source:

biological process summarysupports

Branching morphogenesis requires coordinated interplay between multiple cell types and the extracellular matrix.

Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM).

Source:

developmental stage summarysupports

Branch elongation and tip maturation involve cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation.

Source:

mechanism variation summarysupports

Cell migration, proliferation, rearrangement, deformation, and extracellular matrix dynamics have varied roles in driving budding versus clefting across different organs.

Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs.

Source:

methodology opportunity summarysupports

High-resolution live imaging, tension sensors, and force-mapping techniques are presented as new methodologies that create opportunities for future branching morphogenesis research.

New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.

Source:

process mode summarysupports

New branches in branching morphogenesis form by budding or clefting.

During branching morphogenesis, new branches form by "budding" or "clefting."

Source:

Comparisons

Source-backed strengths

A key strength supported by the evidence is that tension sensors are considered an emerging methodology that expands experimental opportunities in branching morphogenesis research. The cited biological context includes complex events such as cell elongation, intercalation, convergent extension, proliferation, and differentiation during branch elongation and tip maturation.

tension sensors and high throughput screening address a similar problem space because they share recombination.

Shared frame: same top-level item type; shared target processes: recombination

tension sensors and stroke transcriptomics address a similar problem space because they share recombination.

Shared frame: same top-level item type; shared target processes: recombination

tension sensors and whole genome screening of gene knockout mutants address a similar problem space because they share recombination.

Shared frame: same top-level item type; shared target processes: recombination

Ranked Citations

  1. 1.
    StructuralSource 1The Journal of Cell Biology2017Claim 27Claim 26Claim 26

    Seeded from load plan for claim cl1. Extracted from this source document.