Source 1primary paper2019Nature Communications
Toolkit/upconversion nanoparticle-based immunodevice
upconversion nanoparticle-based immunodevice
Also known as: activatable engineered immunodevice, immunodevice, remote-controlled immunodevice
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
The upconversion nanoparticle-based immunodevice is a multi-component, light-activatable immunodevice for remote optical control of antitumor immunity in vitro and in vivo. It combines a rationally designed UV light-activatable immunostimulatory agent with an upconversion nanoparticle that transduces near-infrared light sensitivity into device activation.
Usefulness & Problems
Why this is useful
This tool is useful for spatially selective regulation of antitumor immune activity using near-infrared light rather than direct UV illumination. The reported design enables immune activation within tumors while aiming to avoid disturbing immunity elsewhere, thereby maintaining antitumor efficacy while mitigating systemic toxicity.
Source:
Here we report an activatable engineered immunodevice that enables remote control over the antitumor immunity in vitro and in vivo with near-infrared (NIR) light.
Problem solved
It addresses the problem of how to activate an immunostimulatory agent remotely and selectively in tumors using tissue-penetrant near-infrared light. The upconversion nanoparticle shifts a UV-responsive immunostimulatory system into the NIR window, enabling localized optical control of antitumor immunity.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A composed arrangement of multiple parts that instantiates one or more mechanisms.
Mechanisms
light-triggered activationspatially selective immune stimulationupconversion-mediated wavelength transductionTechniques
Computational DesignTarget processes
No target processes tagged yet.
Input: Light
Implementation Constraints
The construct is described as a combination of a rationally designed UV light-activatable immunostimulatory agent and an upconversion nanoparticle transducer. Practical details such as nanoparticle material, formulation, dosing, delivery route, and exact optical parameters are not specified in the supplied evidence.
The supplied evidence does not identify the specific immunostimulatory agent, nanoparticle composition, excitation wavelength, or quantitative performance metrics. Independent replication is not provided in the supplied record, and validation is supported here by a single 2019 Nature Communications study.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
The activatable engineered immunodevice enables remote control of antitumor immunity with near-infrared light in vitro and in vivo.
Here we report an activatable engineered immunodevice that enables remote control over the antitumor immunity in vitro and in vivo with near-infrared (NIR) light.
The activatable engineered immunodevice enables remote control of antitumor immunity with near-infrared light in vitro and in vivo.
Here we report an activatable engineered immunodevice that enables remote control over the antitumor immunity in vitro and in vivo with near-infrared (NIR) light.
The activatable engineered immunodevice enables remote control of antitumor immunity with near-infrared light in vitro and in vivo.
Here we report an activatable engineered immunodevice that enables remote control over the antitumor immunity in vitro and in vivo with near-infrared (NIR) light.
The activatable engineered immunodevice enables remote control of antitumor immunity with near-infrared light in vitro and in vivo.
Here we report an activatable engineered immunodevice that enables remote control over the antitumor immunity in vitro and in vivo with near-infrared (NIR) light.
The activatable engineered immunodevice enables remote control of antitumor immunity with near-infrared light in vitro and in vivo.
Here we report an activatable engineered immunodevice that enables remote control over the antitumor immunity in vitro and in vivo with near-infrared (NIR) light.
The activatable engineered immunodevice enables remote control of antitumor immunity with near-infrared light in vitro and in vivo.
Here we report an activatable engineered immunodevice that enables remote control over the antitumor immunity in vitro and in vivo with near-infrared (NIR) light.
The activatable engineered immunodevice enables remote control of antitumor immunity with near-infrared light in vitro and in vivo.
Here we report an activatable engineered immunodevice that enables remote control over the antitumor immunity in vitro and in vivo with near-infrared (NIR) light.
The immunodevice is composed of a UV light-activatable immunostimulatory agent and an upconversion nanoparticle that shifts device light sensitivity to the NIR window.
The immunodevice is composed of a rationally designed UV light-activatable immunostimulatory agent and upconversion nanoparticle, which acts as a transducer to shift the light sensitivity of the device to the NIR window.
The immunodevice is composed of a UV light-activatable immunostimulatory agent and an upconversion nanoparticle that shifts device light sensitivity to the NIR window.
The immunodevice is composed of a rationally designed UV light-activatable immunostimulatory agent and upconversion nanoparticle, which acts as a transducer to shift the light sensitivity of the device to the NIR window.
The immunodevice is composed of a UV light-activatable immunostimulatory agent and an upconversion nanoparticle that shifts device light sensitivity to the NIR window.
The immunodevice is composed of a rationally designed UV light-activatable immunostimulatory agent and upconversion nanoparticle, which acts as a transducer to shift the light sensitivity of the device to the NIR window.
The immunodevice is composed of a UV light-activatable immunostimulatory agent and an upconversion nanoparticle that shifts device light sensitivity to the NIR window.
The immunodevice is composed of a rationally designed UV light-activatable immunostimulatory agent and upconversion nanoparticle, which acts as a transducer to shift the light sensitivity of the device to the NIR window.
The immunodevice is composed of a UV light-activatable immunostimulatory agent and an upconversion nanoparticle that shifts device light sensitivity to the NIR window.
The immunodevice is composed of a rationally designed UV light-activatable immunostimulatory agent and upconversion nanoparticle, which acts as a transducer to shift the light sensitivity of the device to the NIR window.
The immunodevice is composed of a UV light-activatable immunostimulatory agent and an upconversion nanoparticle that shifts device light sensitivity to the NIR window.
The immunodevice is composed of a rationally designed UV light-activatable immunostimulatory agent and upconversion nanoparticle, which acts as a transducer to shift the light sensitivity of the device to the NIR window.
The immunodevice is composed of a UV light-activatable immunostimulatory agent and an upconversion nanoparticle that shifts device light sensitivity to the NIR window.
The immunodevice is composed of a rationally designed UV light-activatable immunostimulatory agent and upconversion nanoparticle, which acts as a transducer to shift the light sensitivity of the device to the NIR window.
Controlled immune regulation by the immunodevice allows effective immune response within tumor without disturbing immunity elsewhere, maintaining antitumor efficacy while mitigating systemic toxicity.
The controlled immune regulation allows the generation of effective immune response within tumor without disturbing immunity elsewhere in the body, thereby maintaining the antitumor efficacy while mitigating systemic toxicity.
Controlled immune regulation by the immunodevice allows effective immune response within tumor without disturbing immunity elsewhere, maintaining antitumor efficacy while mitigating systemic toxicity.
The controlled immune regulation allows the generation of effective immune response within tumor without disturbing immunity elsewhere in the body, thereby maintaining the antitumor efficacy while mitigating systemic toxicity.
Controlled immune regulation by the immunodevice allows effective immune response within tumor without disturbing immunity elsewhere, maintaining antitumor efficacy while mitigating systemic toxicity.
The controlled immune regulation allows the generation of effective immune response within tumor without disturbing immunity elsewhere in the body, thereby maintaining the antitumor efficacy while mitigating systemic toxicity.
Controlled immune regulation by the immunodevice allows effective immune response within tumor without disturbing immunity elsewhere, maintaining antitumor efficacy while mitigating systemic toxicity.
The controlled immune regulation allows the generation of effective immune response within tumor without disturbing immunity elsewhere in the body, thereby maintaining the antitumor efficacy while mitigating systemic toxicity.
Controlled immune regulation by the immunodevice allows effective immune response within tumor without disturbing immunity elsewhere, maintaining antitumor efficacy while mitigating systemic toxicity.
The controlled immune regulation allows the generation of effective immune response within tumor without disturbing immunity elsewhere in the body, thereby maintaining the antitumor efficacy while mitigating systemic toxicity.
Controlled immune regulation by the immunodevice allows effective immune response within tumor without disturbing immunity elsewhere, maintaining antitumor efficacy while mitigating systemic toxicity.
The controlled immune regulation allows the generation of effective immune response within tumor without disturbing immunity elsewhere in the body, thereby maintaining the antitumor efficacy while mitigating systemic toxicity.
Controlled immune regulation by the immunodevice allows effective immune response within tumor without disturbing immunity elsewhere, maintaining antitumor efficacy while mitigating systemic toxicity.
The controlled immune regulation allows the generation of effective immune response within tumor without disturbing immunity elsewhere in the body, thereby maintaining the antitumor efficacy while mitigating systemic toxicity.
Approval Evidence
1 source3 linked approval claimsfirst-pass slug upconversion-nanoparticle-based-immunodevice
Here we report an activatable engineered immunodevice that enables remote control over the antitumor immunity in vitro and in vivo with near-infrared (NIR) light. The immunodevice is composed of a rationally designed UV light-activatable immunostimulatory agent and upconversion nanoparticle, which acts as a transducer to shift the light sensitivity of the device to the NIR window.
Source:
capabilitysupports
The activatable engineered immunodevice enables remote control of antitumor immunity with near-infrared light in vitro and in vivo.
Here we report an activatable engineered immunodevice that enables remote control over the antitumor immunity in vitro and in vivo with near-infrared (NIR) light.
Source:
compositionsupports
The immunodevice is composed of a UV light-activatable immunostimulatory agent and an upconversion nanoparticle that shifts device light sensitivity to the NIR window.
The immunodevice is composed of a rationally designed UV light-activatable immunostimulatory agent and upconversion nanoparticle, which acts as a transducer to shift the light sensitivity of the device to the NIR window.
Source:
safety efficacysupports
Controlled immune regulation by the immunodevice allows effective immune response within tumor without disturbing immunity elsewhere, maintaining antitumor efficacy while mitigating systemic toxicity.
The controlled immune regulation allows the generation of effective immune response within tumor without disturbing immunity elsewhere in the body, thereby maintaining the antitumor efficacy while mitigating systemic toxicity.
Source:
Comparisons
Source-backed strengths
The device was reported to enable remote control of antitumor immunity in both in vitro and in vivo settings. Source claims further state that controlled immune regulation produced effective immune responses within tumors without disturbing immunity elsewhere, supporting spatial selectivity and reduced systemic toxicity.
Ranked Citations
- 1.