Source 1primary paper2011Journal of Signal Transduction
Toolkit/WCC
WCC
Also known as: white collar complex
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
WCC, the white collar complex, is a light-responsive heterodimeric complex in Neurospora composed of the PAS-domain-containing proteins WC-1 and WC-2. The available evidence identifies it as a major photoreceptor and suggests a role in transcriptional regulation through zinc-finger-containing subunits.
Usefulness & Problems
Why this is useful
WCC is useful as a native fungal light-sensing switch linked to transcriptional control. The supplied evidence supports its relevance for studying how light input is coupled to gene regulatory outputs in Neurospora cells.
Problem solved
WCC helps address the problem of converting light signals into regulated transcriptional responses in Neurospora. The evidence specifically supports that it is a major photoreceptor complex and that its subunits may function as transcription factors.
Problem links
Need precise spatiotemporal control with light input
DerivedWCC, the white collar complex, is a major photoreceptor in Neurospora cells composed of the PAS-domain-containing polypeptides WC-1 and WC-2. The available evidence indicates that it is a heterodimeric light-responsive complex linked to transcriptional regulation through putative zinc-finger-mediated transcription factor activity.
Need tighter control over gene expression timing or amplitude
DerivedWCC, the white collar complex, is a major photoreceptor in Neurospora cells composed of the PAS-domain-containing polypeptides WC-1 and WC-2. The available evidence indicates that it is a heterodimeric light-responsive complex linked to transcriptional regulation through putative zinc-finger-mediated transcription factor activity.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A composed arrangement of multiple parts that instantiates one or more mechanisms.
Techniques
No technique tags yet.
Target processes
transcriptionInput: Light
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationimplementation constraint: multi component delivery burdenimplementation constraint: spectral hardware requirementoperating role: regulatorswitch architecture: multi componentswitch architecture: recruitment
The available evidence indicates that WCC consists of two components, WC-1 and WC-2, so implementation would require both polypeptides. Beyond PAS-domain content and putative zinc-finger-associated transcriptional function, the supplied sources do not describe construct design, cofactors, expression requirements, or delivery considerations.
The evidence set is narrow and does not provide quantitative performance data, action spectrum, kinetics, reversibility, or direct transcriptional assay results. The transcription factor role is presented as a suggestion based on zinc-finger presence rather than direct functional validation in the supplied text.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
WCC is a heterodimeric complex formed by WC-1 and WC-2.
WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2
WCC is a heterodimeric complex formed by WC-1 and WC-2.
WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2
WCC is a heterodimeric complex formed by WC-1 and WC-2.
WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2
WCC is a heterodimeric complex formed by WC-1 and WC-2.
WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2
WCC is a heterodimeric complex formed by WC-1 and WC-2.
WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2
WCC is a heterodimeric complex formed by WC-1 and WC-2.
WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2
WCC is a heterodimeric complex formed by WC-1 and WC-2.
WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2
WCC is a heterodimeric complex formed by WC-1 and WC-2.
WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2
WCC is a heterodimeric complex formed by WC-1 and WC-2.
WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2
WCC is a heterodimeric complex formed by WC-1 and WC-2.
WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2
WCC is a heterodimeric complex formed by WC-1 and WC-2.
WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2
WCC is a heterodimeric complex formed by WC-1 and WC-2.
WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2
WCC is a heterodimeric complex formed by WC-1 and WC-2.
WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2
WCC is a heterodimeric complex formed by WC-1 and WC-2.
WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2
WCC is a heterodimeric complex formed by WC-1 and WC-2.
WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2
WCC is a heterodimeric complex formed by WC-1 and WC-2.
WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2
WCC is a heterodimeric complex formed by WC-1 and WC-2.
WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2
WCC is a major photoreceptor in Neurospora cells.
A major photoreceptor in Neurospora cells is WCC
WCC is a major photoreceptor in Neurospora cells.
A major photoreceptor in Neurospora cells is WCC
WCC is a major photoreceptor in Neurospora cells.
A major photoreceptor in Neurospora cells is WCC
WCC is a major photoreceptor in Neurospora cells.
A major photoreceptor in Neurospora cells is WCC
WCC is a major photoreceptor in Neurospora cells.
A major photoreceptor in Neurospora cells is WCC
WCC is a major photoreceptor in Neurospora cells.
A major photoreceptor in Neurospora cells is WCC
WCC is a major photoreceptor in Neurospora cells.
A major photoreceptor in Neurospora cells is WCC
WCC is a major photoreceptor in Neurospora cells.
A major photoreceptor in Neurospora cells is WCC
WCC is a major photoreceptor in Neurospora cells.
A major photoreceptor in Neurospora cells is WCC
WCC is a major photoreceptor in Neurospora cells.
A major photoreceptor in Neurospora cells is WCC
WCC is a major photoreceptor in Neurospora cells.
A major photoreceptor in Neurospora cells is WCC
WCC is a major photoreceptor in Neurospora cells.
A major photoreceptor in Neurospora cells is WCC
WCC is a major photoreceptor in Neurospora cells.
A major photoreceptor in Neurospora cells is WCC
WCC is a major photoreceptor in Neurospora cells.
A major photoreceptor in Neurospora cells is WCC
WCC is a major photoreceptor in Neurospora cells.
A major photoreceptor in Neurospora cells is WCC
WCC is a major photoreceptor in Neurospora cells.
A major photoreceptor in Neurospora cells is WCC
WCC is a major photoreceptor in Neurospora cells.
A major photoreceptor in Neurospora cells is WCC
The presence of zinc fingers in WC-1 and WC-2 suggests that they might function as transcription factors.
The presence of zinc fingers (the GATA-recognizing sequences) in both WC-1 and WC-2 proteins suggests that they might function as transcription factors.
The presence of zinc fingers in WC-1 and WC-2 suggests that they might function as transcription factors.
The presence of zinc fingers (the GATA-recognizing sequences) in both WC-1 and WC-2 proteins suggests that they might function as transcription factors.
The presence of zinc fingers in WC-1 and WC-2 suggests that they might function as transcription factors.
The presence of zinc fingers (the GATA-recognizing sequences) in both WC-1 and WC-2 proteins suggests that they might function as transcription factors.
The presence of zinc fingers in WC-1 and WC-2 suggests that they might function as transcription factors.
The presence of zinc fingers (the GATA-recognizing sequences) in both WC-1 and WC-2 proteins suggests that they might function as transcription factors.
The presence of zinc fingers in WC-1 and WC-2 suggests that they might function as transcription factors.
The presence of zinc fingers (the GATA-recognizing sequences) in both WC-1 and WC-2 proteins suggests that they might function as transcription factors.
The presence of zinc fingers in WC-1 and WC-2 suggests that they might function as transcription factors.
The presence of zinc fingers (the GATA-recognizing sequences) in both WC-1 and WC-2 proteins suggests that they might function as transcription factors.
The presence of zinc fingers in WC-1 and WC-2 suggests that they might function as transcription factors.
The presence of zinc fingers (the GATA-recognizing sequences) in both WC-1 and WC-2 proteins suggests that they might function as transcription factors.
The presence of zinc fingers in WC-1 and WC-2 suggests that they might function as transcription factors.
The presence of zinc fingers (the GATA-recognizing sequences) in both WC-1 and WC-2 proteins suggests that they might function as transcription factors.
The presence of zinc fingers in WC-1 and WC-2 suggests that they might function as transcription factors.
The presence of zinc fingers (the GATA-recognizing sequences) in both WC-1 and WC-2 proteins suggests that they might function as transcription factors.
The presence of zinc fingers in WC-1 and WC-2 suggests that they might function as transcription factors.
The presence of zinc fingers (the GATA-recognizing sequences) in both WC-1 and WC-2 proteins suggests that they might function as transcription factors.
The presence of zinc fingers in WC-1 and WC-2 suggests that they might function as transcription factors.
The presence of zinc fingers (the GATA-recognizing sequences) in both WC-1 and WC-2 proteins suggests that they might function as transcription factors.
The presence of zinc fingers in WC-1 and WC-2 suggests that they might function as transcription factors.
The presence of zinc fingers (the GATA-recognizing sequences) in both WC-1 and WC-2 proteins suggests that they might function as transcription factors.
The presence of zinc fingers in WC-1 and WC-2 suggests that they might function as transcription factors.
The presence of zinc fingers (the GATA-recognizing sequences) in both WC-1 and WC-2 proteins suggests that they might function as transcription factors.
The presence of zinc fingers in WC-1 and WC-2 suggests that they might function as transcription factors.
The presence of zinc fingers (the GATA-recognizing sequences) in both WC-1 and WC-2 proteins suggests that they might function as transcription factors.
The presence of zinc fingers in WC-1 and WC-2 suggests that they might function as transcription factors.
The presence of zinc fingers (the GATA-recognizing sequences) in both WC-1 and WC-2 proteins suggests that they might function as transcription factors.
The presence of zinc fingers in WC-1 and WC-2 suggests that they might function as transcription factors.
The presence of zinc fingers (the GATA-recognizing sequences) in both WC-1 and WC-2 proteins suggests that they might function as transcription factors.
The presence of zinc fingers in WC-1 and WC-2 suggests that they might function as transcription factors.
The presence of zinc fingers (the GATA-recognizing sequences) in both WC-1 and WC-2 proteins suggests that they might function as transcription factors.
Approval Evidence
1 source3 linked approval claimsfirst-pass slug wcc
A major photoreceptor in Neurospora cells is WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2
Source:
compositionsupports
WCC is a heterodimeric complex formed by WC-1 and WC-2.
WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2
Source:
molecular functionsupports
WCC is a major photoreceptor in Neurospora cells.
A major photoreceptor in Neurospora cells is WCC
Source:
putative functionsupports
The presence of zinc fingers in WC-1 and WC-2 suggests that they might function as transcription factors.
The presence of zinc fingers (the GATA-recognizing sequences) in both WC-1 and WC-2 proteins suggests that they might function as transcription factors.
Source:
Comparisons
Source-backed strengths
The complex is defined at the component level as a heterodimer of WC-1 and WC-2, and it is described as a major photoreceptor in Neurospora cells. Both subunits are noted to contain PAS domains, and the presence of zinc fingers provides a plausible structural basis for transcription-related activity.
Compared with iLID/SspB
WCC and iLID/SspB address a similar problem space because they share transcription.
Shared frame: same top-level item type; shared target processes: transcription; shared mechanisms: heterodimerization; same primary input modality: light
Relative tradeoffs: appears more independently replicated; looks easier to implement in practice.
Compared with LITEs (Light-inducible transcriptional effectors)
WCC and LITEs (Light-inducible transcriptional effectors) address a similar problem space because they share transcription.
Shared frame: same top-level item type; shared target processes: transcription; shared mechanisms: heterodimerization; same primary input modality: light
Compared with LOVpep/ePDZb
WCC and LOVpep/ePDZb address a similar problem space because they share transcription.
Shared frame: same top-level item type; shared target processes: transcription; shared mechanisms: heterodimerization; same primary input modality: light
Relative tradeoffs: appears more independently replicated; looks easier to implement in practice.
Ranked Citations
- 1.