Source 1review2017British Journal of Pharmacology
Toolkit/zebrafish in vivo drug screening
zebrafish in vivo drug screening
Also known as: zebrafish in vivo drug screening, zebrafish small molecule screening
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
The zebrafish (Danio rerio) is increasingly utilized as a powerful animal model in neuropharmacology research and in vivo drug screening... we also summarize recent developments in zebrafish genetics and small molecule screening, which markedly enhance the disease modelling and the discovery of novel drug targets.
Usefulness & Problems
No literature-backed usefulness or problem-fit explainer has been materialized for this record yet.
Published Workflows
Objective: Use zebrafish-based disease modelling together with in vivo small-molecule screening to support CNS drug discovery and identification of disordered molecular pathways.
Why it works: The abstract presents zebrafish as combining animal disease modelling with in vivo screening, allowing drug-discovery efforts to be linked to phenotype observation and pathway identification in a single vertebrate model.
zebrafish geneticssmall molecule screeningin vivo drug screening
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A delivery strategy grouped with the mechanism branch because it determines how a system is instantiated and deployed in context.
Target processes
recombinationselectionInput: Chemical
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Zebrafish is useful for drug discovery and identification of disordered molecular pathways in neuropsychiatric research.
Recent developments in zebrafish genetics and small-molecule screening markedly enhance disease modelling and discovery of novel drug targets.
Zebrafish is increasingly used as a powerful animal model for neuropharmacology research and in vivo drug screening.
Approval Evidence
1 source3 linked approval claimsfirst-pass slug zebrafish-in-vivo-drug-screening
The zebrafish (Danio rerio) is increasingly utilized as a powerful animal model in neuropharmacology research and in vivo drug screening... we also summarize recent developments in zebrafish genetics and small molecule screening, which markedly enhance the disease modelling and the discovery of novel drug targets.
Source:
application scopesupports
Zebrafish is useful for drug discovery and identification of disordered molecular pathways in neuropsychiatric research.
Source:
method enabling rolesupports
Recent developments in zebrafish genetics and small-molecule screening markedly enhance disease modelling and discovery of novel drug targets.
Source:
utility summarysupports
Zebrafish is increasingly used as a powerful animal model for neuropharmacology research and in vivo drug screening.
Source:
Comparisons
No literature-backed comparison notes have been materialized for this record yet.
Ranked Citations
- 1.