Source 1primary paper2025MED
Toolkit/Ziapin2
Ziapin2
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Ziapin2, a membrane-integrating azobenzene derivative, undergoes light-driven trans-cis isomerization that alters membrane capacitance (Cm).
Usefulness & Problems
No literature-backed usefulness or problem-fit explainer has been materialized for this record yet.
Published Workflows
Objective: Investigate whether the membrane-integrating photoswitch Ziapin2 can modulate conduction velocity in murine cardiomyocyte strands.
Why it works: The abstract states that Ziapin2 changes membrane capacitance through light-driven isomerization, and the study tests whether those capacitance changes alter conduction velocity in cardiomyocyte strands.
light-driven trans-cis isomerizationmembrane capacitance modulationcapacitive load effects on action potential propagationtransient capacitive-driven perturbations of membrane potentialphotostimulationmicroelectrode array recording in cardiomyocyte strands
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A composed arrangement of multiple parts that instantiates one or more mechanisms.
Techniques
No technique tags yet.
Target processes
recombinationInput: Light
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
In strands of neonatal or fetal murine cardiomyocytes cultured on microelectrode arrays, trans-Ziapin2 in the dark significantly reduced conduction velocity.
In the dark, trans-Ziapin2 significantly reduced CV, consistent with increased capacitive load slowing action potential propagation.
conduction velocity significantly reduced
Photostimulation further decreased conduction velocity in Ziapin2-treated murine cardiomyocyte strands.
Unexpectedly, photostimulation further decreased CV, likely reflecting the documented transient, capacitive-driven perturbations of the membrane potential, occurring without alterations in cellular conductances.
conduction velocity further decreased
In its trans configuration, Ziapin2 increases membrane capacitance, and illumination restores membrane capacitance toward baseline.
In its trans configuration, Ziapin2 increases Cm, while illumination relaxes the membrane and restores Cm toward baseline.
Ziapin2 undergoes light-driven trans-cis isomerization that alters membrane capacitance.
Ziapin2, a membrane-integrating azobenzene derivative, undergoes light-driven trans-cis isomerization that alters membrane capacitance (Cm).
Non-genetic light modulation of membrane capacitance can influence cardiac conduction, and Ziapin2 is presented as a novel optical tool to modulate cardiac impulse propagation.
These findings suggest that non-genetic light modulation of membrane capacitance can influence cardiac conduction and establish Ziapin2 as a novel optical tool to modulate cardiac impulse propagation.
Approval Evidence
1 source5 linked approval claimsfirst-pass slug ziapin2
Ziapin2, a membrane-integrating azobenzene derivative, undergoes light-driven trans-cis isomerization that alters membrane capacitance (Cm).
Source:
application effectsupports
In strands of neonatal or fetal murine cardiomyocytes cultured on microelectrode arrays, trans-Ziapin2 in the dark significantly reduced conduction velocity.
In the dark, trans-Ziapin2 significantly reduced CV, consistent with increased capacitive load slowing action potential propagation.
Source:
application effectsupports
Photostimulation further decreased conduction velocity in Ziapin2-treated murine cardiomyocyte strands.
Unexpectedly, photostimulation further decreased CV, likely reflecting the documented transient, capacitive-driven perturbations of the membrane potential, occurring without alterations in cellular conductances.
Source:
mechanismsupports
In its trans configuration, Ziapin2 increases membrane capacitance, and illumination restores membrane capacitance toward baseline.
In its trans configuration, Ziapin2 increases Cm, while illumination relaxes the membrane and restores Cm toward baseline.
Source:
mechanismsupports
Ziapin2 undergoes light-driven trans-cis isomerization that alters membrane capacitance.
Ziapin2, a membrane-integrating azobenzene derivative, undergoes light-driven trans-cis isomerization that alters membrane capacitance (Cm).
Source:
tool positioningsupports
Non-genetic light modulation of membrane capacitance can influence cardiac conduction, and Ziapin2 is presented as a novel optical tool to modulate cardiac impulse propagation.
These findings suggest that non-genetic light modulation of membrane capacitance can influence cardiac conduction and establish Ziapin2 as a novel optical tool to modulate cardiac impulse propagation.
Source:
Comparisons
No literature-backed comparison notes have been materialized for this record yet.
Ranked Citations
- 1.