Source 1primary paper2026PMC
Toolkit/zinc-substituted hydroxyapatite
zinc-substituted hydroxyapatite
Also known as: Zn-HA
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
It reports a 2026 primary study on zinc-substituted hydroxyapatite (Zn-HA) nanoparticles prepared from tuna fish bone waste, then functionalized with Catharanthus roseus flower extract
Usefulness & Problems
Why this is useful
Zinc-substituted hydroxyapatite is the inorganic nanoparticle component used as the base of the reported nanocomposite. It is subsequently functionalized with Catharanthus roseus extract.; nanocomposite core material; bioactive biomaterial formulation
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Zinc-substituted hydroxyapatite is the inorganic nanoparticle component used as the base of the reported nanocomposite. It is subsequently functionalized with Catharanthus roseus extract.
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nanocomposite core material
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bioactive biomaterial formulation
Problem solved
It provides the mineral scaffold and zinc-containing material basis for the composite design.; provides the zinc-containing hydroxyapatite base used for downstream functionalization and testing
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It provides the mineral scaffold and zinc-containing material basis for the composite design.
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provides the zinc-containing hydroxyapatite base used for downstream functionalization and testing
Problem links
provides the zinc-containing hydroxyapatite base used for downstream functionalization and testing
LiteratureIt provides the mineral scaffold and zinc-containing material basis for the composite design.
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It provides the mineral scaffold and zinc-containing material basis for the composite design.
Published Workflows
Catharanthus roseus Extract-Loaded Zn-Substituted Hydroxyapatite Nanocomposites as a Multifunctional Antioxidant and Anticancer Therapeutic Applications
2026Objective: Prepare and evaluate a Catharanthus roseus extract-loaded zinc-substituted hydroxyapatite nanocomposite for multifunctional antioxidant and anticancer therapeutic applications.
plant-extract functionalization of zinc-substituted hydroxyapatitematerials synthesisstructural characterizationin vitro antioxidant assayantibacterial testingcell viability assay
Stages
- 1.Nanoparticle preparation and functionalization(library_build)
This stage creates the Zn-HA/CR nanocomposite that is subsequently characterized and tested.
Selection: Preparation of zinc-substituted hydroxyapatite nanoparticles from tuna fish bone waste followed by Catharanthus roseus extract functionalization to form the nanocomposite.
- 2.Structural characterization(functional_characterization)
This stage assesses material structure before or alongside biological testing.
Selection: Structural characterization of the prepared nanocomposite, including XRD named in the source-discovery summary.
- 3.Antioxidant testing(secondary_characterization)
This stage tests the antioxidant function claimed for the nanocomposite.
Selection: DPPH assay was used to evaluate antioxidant activity.
- 4.Antibacterial testing(secondary_characterization)
This stage evaluates antibacterial performance of the nanocomposite.
Selection: Antibacterial testing was performed against Staphylococcus aureus and Escherichia coli.
- 5.Cytotoxicity testing in osteosarcoma cells(confirmatory_validation)
This stage evaluates anticancer application in a cell-based model.
Selection: MTT cytotoxicity testing was performed in MG-63/HOS osteosarcoma cells.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A reusable architecture pattern for arranging parts into an engineered system.
Techniques
No technique tags yet.
Target processes
No target processes tagged yet.
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: actuator
The summary indicates preparation from tuna fish bone waste followed by downstream functionalization and characterization.; requires nanoparticle preparation from fish-bone-derived hydroxyapatite route according to the summary
the provided evidence does not specify zinc substitution level or comparative performance in this paper excerpt
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
The reported nanocomposite consists of zinc-substituted hydroxyapatite functionalized or loaded with Catharanthus roseus extract.
The study evaluated the material using structural characterization, DPPH antioxidant assay, antibacterial testing against Staphylococcus aureus and Escherichia coli, and MTT cytotoxicity testing in MG-63/HOS osteosarcoma cells.
The paper reports Catharanthus roseus extract-loaded zinc-substituted hydroxyapatite nanocomposites for multifunctional antioxidant and anticancer therapeutic applications.
Approval Evidence
1 source1 linked approval claimfirst-pass slug zinc-substituted-hydroxyapatite
It reports a 2026 primary study on zinc-substituted hydroxyapatite (Zn-HA) nanoparticles prepared from tuna fish bone waste, then functionalized with Catharanthus roseus flower extract
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compositionsupports
The reported nanocomposite consists of zinc-substituted hydroxyapatite functionalized or loaded with Catharanthus roseus extract.
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Comparisons
Source-stated alternatives
The source-discovery scaffold contrasts this with hydroxyapatite more generally and with other zinc-doped hydroxyapatite nanocomposites.
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The source-discovery scaffold contrasts this with hydroxyapatite more generally and with other zinc-doped hydroxyapatite nanocomposites.
Source-backed strengths
serves as the core material component in the reported multifunctional nanocomposite
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serves as the core material component in the reported multifunctional nanocomposite
Ranked Citations
- 1.