Browse the toolkit beneath workflows. The mechanism branch runs mechanism -> architecture -> component, while the technique branch runs from high-level approaches down to concrete methods.
2 items matching 1 filter
Mechanism Branch
Layer 1
Mechanisms
Top-level concepts: biophysical action modes such as heterodimerization, photocleavage, or RNA binding.
Layer 2
Architectures
Arrangements that realize or deploy mechanisms, including switches, construct patterns, and delivery strategies.
Layer 3
Components
Low-level parts and sequence-defined elements used inside architectures, including protein domains and RNA elements.
Technique Branch
Layer 1
Approaches
High-level engineering practices such as computational design, directed evolution, sequence verification, and functional assay.
Layer 2
Methods
Concrete methods used to design, build, verify, or characterize engineered systems.
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Here, we developed two types of SG inhibitory peptides (SIPs) derived from SG core proteins Caprin1 and USP10 and fused with cell-penetrating peptides
Tat-derived cell penetrating peptide derivatized UNC10245092 is a C-terminal Tat-CPP-modified version of the CIB1-binding peptide UNC10245092 designed for intracellular delivery in cell culture. The parent peptide binds calcium and integrin binding protein 1 (CIB1) with low nanomolar affinity, and the Tat-derivatized construct produced effects in triple-negative breast cancer cells consistent with CIB1 depletion.