Toolkit Items

A detailed functional characterization of electrogenic cells, such as neurons and cardiomyocytes, by means of high-density microelectrode arrays (HD-MEAs) has emerged as a powerful approach for inferring cellular phenotypes and elucidating fundamental mechanisms underlying cellular function.

In this work, we present "inkube", an incubation system that has been combined with an electrophysiology setup and a fully automatic perfusion system.

The acute slice preparation can be a powerful tool to study brain networks that would otherwise be difficult to manipulate at the synaptic and cellular levels.

Microelectrode arrays and microprobes have been widely utilized to measure neuronal activity, both in vitro and in vivo. The key advantage is the capability to record and stimulate neurons at multiple sites simultaneously.

Microelectrode arrays and microprobes have been widely utilized to measure neuronal activity, both in vitro and in vivo.

Transparent microelectrodes have emerged as promising tools to combine electrical and optical sensing and modulation modalities... In addition to optical transparency, the mechanical softness feature is desired to minimize foreign body responses, increase biocompatibility, and avoid loss of functionality.

Novel 3D microelectrode arrays permit high-resolution spatiotemporal electrophysiological signaling and recording to explore the capacity of brain organoids to recapitulate the molecular mechanisms of learning and memory formation and, ultimately, their computational potential.

We then discuss examples of soft transparent microelectrode arrays tailored to combine electrical recording and/or stimulation with optical imaging and/or optogenetic modulation of the brain and the heart.

We relate relevant findings from non-invasive methods used in humans to those obtained from direct electrical and optogenetic stimulation of neuronal ensembles in animal models.

Voltage and current controlled electrical neural stimulation (ENS) are methods that have already been widely applied in both neuroscience and clinical practice for neuroprosthetics.

including wireless recording and stimulation systems (particularly responsive neurostimulation [NeuroPace])

The paper describes a wireless, battery-free, fully implantable pacing platform with electrical and optical stimulation and multisite pacing for small animal models.