Browse the toolkit beneath workflows. The mechanism branch runs mechanism -> architecture -> component, while the technique branch runs from high-level approaches down to concrete methods.
8 items matching 1 filter
Mechanism Branch
Layer 1
Mechanisms
Top-level concepts: biophysical action modes such as heterodimerization, photocleavage, or RNA binding.
Layer 2
Architectures
Arrangements that realize or deploy mechanisms, including switches, construct patterns, and delivery strategies.
Layer 3
Components
Low-level parts and sequence-defined elements used inside architectures, including protein domains and RNA elements.
Technique Branch
Layer 1
Approaches
High-level engineering practices such as computational design, directed evolution, sequence verification, and functional assay.
Layer 2
Methods
Concrete methods used to design, build, verify, or characterize engineered systems.
Showing 1-8 of 8
Chrimson is a red light-activated channelrhodopsin with a reported crystal structure. It provides red-shifted optogenetic excitation and has been used with Chronos to support two-color activation of independent neural populations in mouse brain slice without detectable cross-talk.
ChETA is a light-responsive protein domain considered here only in a theoretical co-expression strategy with step-function opsins (SFOs). In that context, modeling predicted that ChETA-SFO co-expression in hippocampal neurons would stabilize photocurrent and reduce spike failure associated with photocurrent desensitization.
chimera D (ChD) is an engineered channelrhodopsin variant identified in a comparative review of channelrhodopsin tools. The supplied evidence indicates that it emerged from chimeragenesis, mutagenesis, and bioinformatic engineering efforts, but does not describe its specific functional properties or application behavior.
chimera EF (ChEF) is an engineered channelrhodopsin variant identified in a 2010 review as part of the broader set of modified channelrhodopsins. The supplied evidence indicates that it was introduced through chimeragenesis, mutagenesis, and bioinformatic approaches, but does not provide its specific design or functional characterization.
chimera EF I170V is an engineered channelrhodopsin variant described as a ChEF chimera carrying the I170V mutation. The supplied evidence identifies it as an optogenetic light-gated ion channel variant but does not provide direct functional characterization for this specific construct.
Volvox carteri channelrhodopsin-1 (VChR1) is a channelrhodopsin variant identified in the comparative optogenetics literature as part of the channelrhodopsin tool class for light-based biological control. The supplied evidence names VChR1 as an additional engineered or identified variant but does not provide variant-specific functional properties.
High-signal enrichment leads found around this anchor cluster into ... opsin-engineering papers explicitly tied to SGN/oCI performance, especially CatCh, Chronos, and red-shifted Chrimson-family work.
(b) cryptophyte cation channelrhodopsins (CCRs), structurally distinct from the green algae CCRs used extensively for neural activation and from cryptophyte ACRs