Browse the toolkit beneath workflows. The mechanism branch runs mechanism -> architecture -> component, while the technique branch runs from high-level approaches down to concrete methods.
5 items matching 1 filter
Mechanism Branch
Layer 1
Mechanisms
Top-level concepts: biophysical action modes such as heterodimerization, photocleavage, or RNA binding.
Layer 2
Architectures
Arrangements that realize or deploy mechanisms, including switches, construct patterns, and delivery strategies.
Layer 3
Components
Low-level parts and sequence-defined elements used inside architectures, including protein domains and RNA elements.
Technique Branch
Layer 1
Approaches
High-level engineering practices such as computational design, directed evolution, sequence verification, and functional assay.
Layer 2
Methods
Concrete methods used to design, build, verify, or characterize engineered systems.
Showing 1-5 of 5
The near-infrared activatable protein-conjugated nanoparticle is a nanoparticle-based delivery harness reported for efficient spatially targeted gene editing in brain applications. The available evidence indicates that it combines protein-conjugated nanoparticle delivery with near-infrared activation to localize editing activity.
Camouflage nanoparticle-based vectors are biomimetic delivery systems developed for in situ bioluminescence-driven optogenetic therapy of retinoblastoma. In the cited 2023 ACS Nano study, this system enabled optogenetic treatment and showed greater tumor inhibition than external blue light irradiation.
We discuss technological innovations that have overcome historic challenges related to RNA instability, immunogenicity, and delivery, with particular emphasis on lipid nanoparticle formulations and targeted ligand conjugates.
To improve nanobody delivery precision, half-life, and efficacy, strategies such as integrating nanobodies with nanoparticles, dendrimers, liposomes, and viral vectors are being employed.
This review examines recent advancements in nanoparticle( s) (NPs) delivery systems, with a focus on RNA-coated liposomes, lipid nanoparticles (LNPs), and size- and surface-modifiable NPs