Toolkit Items

Browse the toolkit beneath workflows. The mechanism branch runs mechanism -> architecture -> component, while the technique branch runs from high-level approaches down to concrete methods.

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Mechanism Branch

Layer 1

Mechanisms

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Top-level concepts: biophysical action modes such as heterodimerization, photocleavage, or RNA binding.

Layer 2

Architectures

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Arrangements that realize or deploy mechanisms, including switches, construct patterns, and delivery strategies.

Layer 3

Components

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Low-level parts and sequence-defined elements used inside architectures, including protein domains and RNA elements.

Technique Branch

Layer 1

Approaches

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High-level engineering practices such as computational design, directed evolution, sequence verification, and functional assay.

Layer 2

Methods

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Concrete methods used to design, build, verify, or characterize engineered systems.

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optical activation of neural activity

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microbial opsins

Multi-Component Switch
Since 2011light-gated ion transportmodulation of g-protein-coupled intracellular signalingoptical activation of neural activityoptical silencing of neural activityComputational Design

Microbial opsins are genetically encoded seven-transmembrane proteins from diverse microorganisms that render cells light responsive by transporting ions across cellular lipid membranes. In optogenetics, they are used as molecular sensitizers to activate or silence neural activity with brief pulses of light.

CFBacMamMusHumTxRep
Ev 37Rep 9Pr 25
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