Browse the toolkit beneath workflows. The mechanism branch runs mechanism -> architecture -> component, while the technique branch runs from high-level approaches down to concrete methods.
11 items matching 1 filter
Mechanism Branch
Layer 1
Mechanisms
Top-level concepts: biophysical action modes such as heterodimerization, photocleavage, or RNA binding.
Layer 2
Architectures
Arrangements that realize or deploy mechanisms, including switches, construct patterns, and delivery strategies.
Layer 3
Components
Low-level parts and sequence-defined elements used inside architectures, including protein domains and RNA elements.
Technique Branch
Layer 1
Approaches
High-level engineering practices such as computational design, directed evolution, sequence verification, and functional assay.
Layer 2
Methods
Concrete methods used to design, build, verify, or characterize engineered systems.
Showing 1-11 of 11
Herein, we present a 3D high-density multifunctional MEA with optical stimulation and drug delivery for investigating neural circuit dynamics within engineered 3D neural tissues.
recent advances in optogenetic actuators, genetically encoded calcium and voltage indicators, and patterned photostimulation have transformed in vitro research, enabling all-optical interrogation of synaptic plasticity, functional connectivity, and emergent network dynamics.
FLIPR (Fluorometric Imaging Plate Reader) is a fluorescence-analysis instrument used as a miniaturized optogenetic assay platform in 384-well plates. In the cited study, FLIPR LEDs provided optical modulation to support recombinant cellular assays, including Channelrhodopsin-2 control of CaV1.3.
LAVA is a set of engineered illumination devices for optogenetic photostimulation and light activation at variable amplitudes. It delivers user-defined light intensity, temporal sequences, and spatial patterns to control signaling responses, including optogenetic Wnt/beta-catenin pathway activation.
The optoPlateReader (oPR) is an open-source, solid-state, compact hardware platform for automated optogenetic stimulation and spectroscopy in each well of a 96-well plate. It combines an optoPlate illumination module with an optoReader module containing 96 photodiodes and LEDs to enable 96 parallel light measurements and feedback-enabled optical experiments.
RAMalgo (reproducible automated multimodal algometry) improves the standardization, comprehensiveness, and throughput of preclinical pain testing.
Implantable optical devices are being extensively developed to study particular electrophysiological phenomena with the precise control that optogenetics provides.
Microtiter plate designs for optogenetic stimulation are light-delivery platform formats used to apply regulated optical inputs in biological experiments. The cited review places these designs within a broader range of optogenetic hardware spanning simple illumination setups to microtiter plate and bioreactor implementations, with use cases from single-cell stimulation to whole-culture illumination.
We relate relevant findings from non-invasive methods used in humans to those obtained from direct electrical and optogenetic stimulation of neuronal ensembles in animal models.
The paper describes a wireless, battery-free, fully implantable pacing platform with electrical and optical stimulation and multisite pacing for small animal models.
Web research summary: the review surveys integrated optoelectrodes; related item candidate: μLED silicon neural probes; high-signal source: monolithically integrated μLEDs on silicon neural probes for simultaneous optogenetic stimulation and electrophysiology.