Browse the toolkit beneath workflows. The mechanism branch runs mechanism -> architecture -> component, while the technique branch runs from high-level approaches down to concrete methods.
6 items matching 1 filter
Mechanism Branch
Layer 1
Mechanisms
Top-level concepts: biophysical action modes such as heterodimerization, photocleavage, or RNA binding.
Layer 2
Architectures
Arrangements that realize or deploy mechanisms, including switches, construct patterns, and delivery strategies.
Layer 3
Components
Low-level parts and sequence-defined elements used inside architectures, including protein domains and RNA elements.
Technique Branch
Layer 1
Approaches
High-level engineering practices such as computational design, directed evolution, sequence verification, and functional assay.
Layer 2
Methods
Concrete methods used to design, build, verify, or characterize engineered systems.
Showing 1-6 of 6
Here we describe multifunctional neural interfaces that combine the scalability and mechanical versatility of thermally drawn polymer-based fibers with the sophistication of microelectronic chips for organs as diverse as the brain and the gut. Our approach uses meters-long continuous fibers that can integrate light sources, electrodes, thermal sensors and microfluidic channels in a miniature footprint.
Two-photon guided whole-cell recording is an emerging electrophysiological assay method identified as combinable with the optogenetic toolbox. In the cited epilepsy context, it is positioned for recording from defined cells while optogenetic perturbations are used to probe circuit function.
integration of optogenetic and microelectrode array mapping enables visualization of functional patterning in assembloids
Furthermore, optogenetic interrogation of selected Purkinje cell regions during animal behavior confirms the functional regionalization of Purkinje cell efferents and reveals their contribution to behavior control as well as their function in controlling lateralized behavioral output.
Under 1P excitation, crosstalk was evident in the GCaMP6m (blue)/ChRmine (red) pair.
Under 1P excitation, crosstalk was evident in the GCaMP6m (blue)/ChRmine (red) pair, but negligible in the R-CaMP1.07 (red)/eTsChR (blue) pair.