Toolkit Items

Browse the toolkit beneath workflows. The mechanism branch runs mechanism -> architecture -> component, while the technique branch runs from high-level approaches down to concrete methods.

5 items matching 1 filter

Mechanism Branch

Layer 1

Mechanisms

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Top-level concepts: biophysical action modes such as heterodimerization, photocleavage, or RNA binding.

Layer 2

Architectures

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Arrangements that realize or deploy mechanisms, including switches, construct patterns, and delivery strategies.

Layer 3

Components

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Low-level parts and sequence-defined elements used inside architectures, including protein domains and RNA elements.

Technique Branch

Layer 1

Approaches

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High-level engineering practices such as computational design, directed evolution, sequence verification, and functional assay.

Layer 2

Methods

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Concrete methods used to design, build, verify, or characterize engineered systems.

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photodynamic therapy

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decitabine nanomicelles (NP2)

Delivery Strategy
Since 2023cgas-sting pathway activationepigenetic therapylight-controlled activationphotodynamic therapypyroptosis activation

NP2 denotes decitabine nanomicelles incorporated into a tumor-specific, light-controlled nanotheranostic platform. In the reported 2023 Advanced Materials study, NP2 is used together with oxidation-sensitive nanoparticles loaded with TBE to combine epigenetic therapy with photodynamic therapy for tumor photoimmunotherapy.

CFBacMamMusHumTxRep
Ev 28Rep 9Pr 59

Photodynamic therapy strategy based on FBX4-cyclin D1 combination mode

Construct Pattern
Since 2022photodynamic therapy

This tool is a proposed photodynamic therapy strategy based on an FBX4-cyclin D1 combination mode for treatment of superficial cancer. The available evidence describes a conceptual therapeutic approach rather than a defined, experimentally characterized biological construct.

CFBacMamMusHumTxRep
Ev 20Rep 9Pr 59

bioluminescence resonant energy transfer

Multi-Component Switch
Since 2015bioluminescence resonant energy transferphotochemical activationphotodynamic therapy

Bioluminescence resonant energy transfer (BRET) is a multi-component light-activation strategy that uses bioluminescence to induce photochemical activation for photodynamic therapy. In the cited 2015 cancer study, BRET-driven therapy produced cytotoxicity comparable to external red laser irradiation and was applied against deep-tissue tumors, metastases, and tumor-bearing lymph nodes.

CFBacMamMusHumTxRep
Ev 36Rep 9Pr 37

tumor-specific nanotheranostic platform combining photodynamic therapy with epigenetic therapy

Multi-Component Switch
Since 2023cgas-sting pathway activationepigenetic therapyoxidation-sensitive nanoparticle responsephotodynamic therapypyroptosis activation

This tool is a tumor-specific, light-controlled nanotheranostic platform that combines photodynamic therapy with epigenetic therapy. It is constructed to simultaneously activate pyroptosis and the cGAS-STING pathway for enhanced tumor photoimmunotherapy.

CFBacMamMusHumTxRep
Ev 28Rep 9Pr 37
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