Browse the toolkit beneath workflows. The mechanism branch runs mechanism -> architecture -> component, while the technique branch runs from high-level approaches down to concrete methods.
3 items matching 1 filter
Mechanism Branch
Layer 1
Mechanisms
Top-level concepts: biophysical action modes such as heterodimerization, photocleavage, or RNA binding.
Layer 2
Architectures
Arrangements that realize or deploy mechanisms, including switches, construct patterns, and delivery strategies.
Layer 3
Components
Low-level parts and sequence-defined elements used inside architectures, including protein domains and RNA elements.
Technique Branch
Layer 1
Approaches
High-level engineering practices such as computational design, directed evolution, sequence verification, and functional assay.
Layer 2
Methods
Concrete methods used to design, build, verify, or characterize engineered systems.
Showing 1-3 of 3
The human CIB1-EVER1-EVER2 complex is a multicomponent protein complex in keratinocytes composed of CIB1, EVER1, and EVER2. It is reported to govern keratinocyte-intrinsic immunity to β-papillomaviruses, and disruption of this complex-dependent pathway is linked to selective susceptibility to β-HPVs in epidermodysplasia verruciformis.
PAR3/INSC/LGN is an evolutionarily conserved multi-protein complex that forms a polarity-associated machinery required for asymmetric cell division in the developing brain. Human genetic evidence further links this machinery to function in the adult peripheral nervous system, where its dysfunction is associated with tubulin aggregation and necrotic neurodegeneration.
The OCP–FRP protein complex is a cyanobacterial multi-protein light-related system composed of orange carotenoid protein (OCP) and fluorescence recovery protein (FRP). Reported OCP–FRP complex topologies suggest a mechanism for controlling high light tolerance in cyanobacteria.