Browse the toolkit beneath workflows. The mechanism branch runs mechanism -> architecture -> component, while the technique branch runs from high-level approaches down to concrete methods.
4 items matching 1 filter
Mechanism Branch
Layer 1
Mechanisms
Top-level concepts: biophysical action modes such as heterodimerization, photocleavage, or RNA binding.
Layer 2
Architectures
Arrangements that realize or deploy mechanisms, including switches, construct patterns, and delivery strategies.
Layer 3
Components
Low-level parts and sequence-defined elements used inside architectures, including protein domains and RNA elements.
Technique Branch
Layer 1
Approaches
High-level engineering practices such as computational design, directed evolution, sequence verification, and functional assay.
Layer 2
Methods
Concrete methods used to design, build, verify, or characterize engineered systems.
Showing 1-4 of 4
we developed a novel multi-target opening volume expansion (MOVE) pulse sequence to maximize BBB opening volume within a single ThUS treatment. ThUS MOVE yielded increased gene delivery commensurate with the number of targeted focal zones and achieved brain-wide expression of GEVI
We highlight the following technologies: ... ultrasound-responsive nanoparticles...
Focused ultrasound (FUS) combined with microbubbles (MBs) can transiently open the BBB through mechanisms such as cavitation, modulation of tight junction protein expression, and enhanced vesicular transport in endothelial cells.
Magnetic resonance-guided focused ultrasound (MRgFUS) has recently emerged as a non-invasive neuromodulation alternative, providing incisionless lesioning for selected cases, particularly tremor-dominant phenotypes.