Browse the toolkit beneath workflows. The mechanism branch runs mechanism -> architecture -> component, while the technique branch runs from high-level approaches down to concrete methods.
4 items matching 1 filter
Mechanism Branch
Layer 1
Mechanisms
Top-level concepts: biophysical action modes such as heterodimerization, photocleavage, or RNA binding.
Layer 2
Architectures
Arrangements that realize or deploy mechanisms, including switches, construct patterns, and delivery strategies.
Layer 3
Components
Low-level parts and sequence-defined elements used inside architectures, including protein domains and RNA elements.
Technique Branch
Layer 1
Approaches
High-level engineering practices such as computational design, directed evolution, sequence verification, and functional assay.
Layer 2
Methods
Concrete methods used to design, build, verify, or characterize engineered systems.
Showing 1-4 of 4
Mechanistically, EVs from ischemia-evoked neuronal activity induce neuronal apoptosis and innate immune responses by transferring higher miR-100-5p to adjacent neuron and microglia. MiR-100-5p can bind to and activate TLR7 through U18U19G20-motif, thereby activating NF-κB pathway.
Explicitly supported by the anchor paper for simultaneous chemogenetic reactivation of multiple engram ensembles.
Chemogenetically driven repositioning of lysosomes is an experimental perturbation used to causally alter lysosome localization and test how lysosome positioning regulates endoplasmic reticulum remodeling. In the cited 2020 Science Advances study, chemo- and optogenetically driven lysosome repositioning was used to validate a causal link between lysosome movement and ER network organization.
Optogenetically driven repositioning of lysosomes is a light-controlled perturbation method used to move lysosomes and test their causal role in endoplasmic reticulum remodeling. In the cited 2020 study, chemo- and optogenetically driven lysosome repositioning was used to validate a causal link between lysosome positioning and ER network organization.