Source 1review2020Frontiers in Neuroinformatics
Toolkit/animal functional magnetic resonance imaging
animal functional magnetic resonance imaging
Also known as: animal fMRI, whole-brain functional magnetic resonance imaging
Taxonomy: Technique Branch / Method. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Animal whole-brain functional magnetic resonance imaging (fMRI) provides a non-invasive window into brain activity.
Usefulness & Problems
Why this is useful
Animal fMRI is described as a non-invasive whole-brain method for observing brain activity. The review frames it as a way to study distributed neuronal activity in animal models.; non-invasive whole-brain measurement of brain activity in animals; replicating observations made in humans in animal models; studying distributed neuronal activity in healthy and disordered brain
Source:
Animal fMRI is described as a non-invasive whole-brain method for observing brain activity. The review frames it as a way to study distributed neuronal activity in animal models.
Source:
non-invasive whole-brain measurement of brain activity in animals
Source:
replicating observations made in humans in animal models
Source:
studying distributed neuronal activity in healthy and disordered brain
Problem solved
It provides a way to examine whole-brain activity in animals and to connect animal observations with human neuroimaging findings.; provides a whole-brain, non-invasive readout for animal neuroimaging studies
Source:
It provides a way to examine whole-brain activity in animals and to connect animal observations with human neuroimaging findings.
Source:
provides a whole-brain, non-invasive readout for animal neuroimaging studies
Problem links
provides a whole-brain, non-invasive readout for animal neuroimaging studies
LiteratureIt provides a way to examine whole-brain activity in animals and to connect animal observations with human neuroimaging findings.
Source:
It provides a way to examine whole-brain activity in animals and to connect animal observations with human neuroimaging findings.
Published Workflows
Objective: Improve comparability and between-lab reproducibility in animal fMRI studies by standardizing the major methodological phases that influence results.
Why it works: The review states that critical aspects in study design, data acquisition, and post-processing affect results and influence comparability, so harmonizing these phases is presented as the route toward improved reproducibility.
study design harmonizationdata acquisition standardizationpost-processing standardization
Stages
- 1.study design(decision_gate)
The abstract identifies study design as a critical aspect that may affect results and influence comparability between studies.
Selection: Design choices that affect results and comparability between studies.
- 2.data acquisition(functional_characterization)
The abstract explicitly highlights data acquisition as a critical aspect that may affect results and influence comparability between studies.
Selection: Acquisition operations that affect results and cross-study comparability.
- 3.post-processing operations(secondary_characterization)
The abstract explicitly identifies post-processing operations as a critical aspect influencing results and comparability.
Selection: Post-processing choices that affect results and comparability between studies.
Taxonomy & Function
Primary hierarchy
Technique Branch
Method: A concrete measurement method used to characterize an engineered system.
Mechanisms
functional magnetic resonance imagingTechniques
Functional AssayTarget processes
No target processes tagged yet.
Input: Magnetic
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: sensor
The abstract supports that execution depends on study design, data acquisition, and post-processing operations. It also implies a neuroimaging protocol that can be standardized across centers.; requires attention to study design; requires standardized data acquisition; requires standardized post-processing for comparability
The abstract indicates that animal fMRI alone does not solve cross-site comparability, because sensitivity and specificity can still differ substantially without standardization.; between-site comparisons are hampered by lack of standardization; results are affected by study design, data acquisition, and post-processing choices
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Animal whole-brain fMRI provides a non-invasive window into brain activity.
Animal fMRI studies have developed rapidly in recent years, fueled by resting-state fMRI connectivity and genetically encoded neuromodulatory tools.
Comparisons between sites in animal fMRI remain hampered by lack of standardization.
Standardized animal neuroimaging protocols are expected to improve between-lab reproducibility and facilitate population imaging, meta-analysis, and replication studies.
Approval Evidence
1 source3 linked approval claimsfirst-pass slug animal-functional-magnetic-resonance-imaging
Animal whole-brain functional magnetic resonance imaging (fMRI) provides a non-invasive window into brain activity.
Source:
capability summarysupports
Animal whole-brain fMRI provides a non-invasive window into brain activity.
Source:
field trendsupports
Animal fMRI studies have developed rapidly in recent years, fueled by resting-state fMRI connectivity and genetically encoded neuromodulatory tools.
Source:
reproducibility limitationsupports
Comparisons between sites in animal fMRI remain hampered by lack of standardization.
Source:
Comparisons
Source-stated alternatives
The abstract does not name direct alternative imaging modalities, but it does contrast broad associated methods and genetically encoded neuromodulatory tools as related enabling approaches.
Source:
The abstract does not name direct alternative imaging modalities, but it does contrast broad associated methods and genetically encoded neuromodulatory tools as related enabling approaches.
Source-backed strengths
non-invasive; whole-brain scope
Source:
non-invasive
Source:
whole-brain scope
Compared with imaging
The abstract does not name direct alternative imaging modalities, but it does contrast broad associated methods and genetically encoded neuromodulatory tools as related enabling approaches.
Shared frame: source-stated alternative in extracted literature
Strengths here: non-invasive; whole-brain scope.
Relative tradeoffs: between-site comparisons are hampered by lack of standardization; results are affected by study design, data acquisition, and post-processing choices.
Source:
The abstract does not name direct alternative imaging modalities, but it does contrast broad associated methods and genetically encoded neuromodulatory tools as related enabling approaches.
Compared with imaging surveillance
The abstract does not name direct alternative imaging modalities, but it does contrast broad associated methods and genetically encoded neuromodulatory tools as related enabling approaches.
Shared frame: source-stated alternative in extracted literature
Strengths here: non-invasive; whole-brain scope.
Relative tradeoffs: between-site comparisons are hampered by lack of standardization; results are affected by study design, data acquisition, and post-processing choices.
Source:
The abstract does not name direct alternative imaging modalities, but it does contrast broad associated methods and genetically encoded neuromodulatory tools as related enabling approaches.
Ranked Citations
- 1.