Source 1primary paper2026PMC
Toolkit/Catharanthus roseus extract-loaded Zn-substituted hydroxyapatite nanocomposites
Catharanthus roseus extract-loaded Zn-substituted hydroxyapatite nanocomposites
Also known as: Zn-HA/CR nanocomposite
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Catharanthus roseus Extract-Loaded Zn-Substituted Hydroxyapatite Nanocomposites as a Multifunctional Antioxidant and Anticancer Therapeutic Applications
Usefulness & Problems
Why this is useful
This paper presents a nanocomposite made by loading Catharanthus roseus extract onto zinc-substituted hydroxyapatite. The material is positioned as a multifunctional antioxidant and anticancer therapeutic candidate.; multifunctional antioxidant biomaterial evaluation; anticancer biomaterial evaluation
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This paper presents a nanocomposite made by loading Catharanthus roseus extract onto zinc-substituted hydroxyapatite. The material is positioned as a multifunctional antioxidant and anticancer therapeutic candidate.
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multifunctional antioxidant biomaterial evaluation
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anticancer biomaterial evaluation
Problem solved
It aims to combine a zinc-containing hydroxyapatite biomaterial platform with plant-extract bioactivity in one composite for therapeutic testing.; combines zinc-substituted hydroxyapatite with Catharanthus roseus extract in a single nanocomposite for antioxidant and anticancer testing
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It aims to combine a zinc-containing hydroxyapatite biomaterial platform with plant-extract bioactivity in one composite for therapeutic testing.
Source:
combines zinc-substituted hydroxyapatite with Catharanthus roseus extract in a single nanocomposite for antioxidant and anticancer testing
Problem links
combines zinc-substituted hydroxyapatite with Catharanthus roseus extract in a single nanocomposite for antioxidant and anticancer testing
LiteratureIt aims to combine a zinc-containing hydroxyapatite biomaterial platform with plant-extract bioactivity in one composite for therapeutic testing.
Source:
It aims to combine a zinc-containing hydroxyapatite biomaterial platform with plant-extract bioactivity in one composite for therapeutic testing.
Published Workflows
Catharanthus roseus Extract-Loaded Zn-Substituted Hydroxyapatite Nanocomposites as a Multifunctional Antioxidant and Anticancer Therapeutic Applications
2026Objective: Prepare and evaluate a Catharanthus roseus extract-loaded zinc-substituted hydroxyapatite nanocomposite for multifunctional antioxidant and anticancer therapeutic applications.
plant-extract functionalization of zinc-substituted hydroxyapatitematerials synthesisstructural characterizationin vitro antioxidant assayantibacterial testingcell viability assay
Stages
- 1.Nanoparticle preparation and functionalization(library_build)
This stage creates the Zn-HA/CR nanocomposite that is subsequently characterized and tested.
Selection: Preparation of zinc-substituted hydroxyapatite nanoparticles from tuna fish bone waste followed by Catharanthus roseus extract functionalization to form the nanocomposite.
- 2.Structural characterization(functional_characterization)
This stage assesses material structure before or alongside biological testing.
Selection: Structural characterization of the prepared nanocomposite, including XRD named in the source-discovery summary.
- 3.Antioxidant testing(secondary_characterization)
This stage tests the antioxidant function claimed for the nanocomposite.
Selection: DPPH assay was used to evaluate antioxidant activity.
- 4.Antibacterial testing(secondary_characterization)
This stage evaluates antibacterial performance of the nanocomposite.
Selection: Antibacterial testing was performed against Staphylococcus aureus and Escherichia coli.
- 5.Cytotoxicity testing in osteosarcoma cells(confirmatory_validation)
This stage evaluates anticancer application in a cell-based model.
Selection: MTT cytotoxicity testing was performed in MG-63/HOS osteosarcoma cells.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A reusable architecture pattern for arranging parts into an engineered system.
Target processes
No target processes tagged yet.
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: actuator
The reported system requires zinc-substituted hydroxyapatite, Catharanthus roseus extract, and characterization and bioactivity assays such as XRD, DPPH, antibacterial testing, and MTT testing.; requires preparation of zinc-substituted hydroxyapatite nanoparticles; requires Catharanthus roseus extract loading/functionalization; requires downstream characterization and bioactivity assays
The provided evidence does not show in vivo efficacy, clinical utility, or manufacturing robustness.; available evidence here does not support quantitative performance values; evidence here is limited to source metadata and upstream summary rather than direct abstract text
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
The reported nanocomposite consists of zinc-substituted hydroxyapatite functionalized or loaded with Catharanthus roseus extract.
The study evaluated the material using structural characterization, DPPH antioxidant assay, antibacterial testing against Staphylococcus aureus and Escherichia coli, and MTT cytotoxicity testing in MG-63/HOS osteosarcoma cells.
The paper reports Catharanthus roseus extract-loaded zinc-substituted hydroxyapatite nanocomposites for multifunctional antioxidant and anticancer therapeutic applications.
Approval Evidence
1 source3 linked approval claimsfirst-pass slug catharanthus-roseus-extract-loaded-zn-substituted-hydroxyapatite-nanocomposites
Catharanthus roseus Extract-Loaded Zn-Substituted Hydroxyapatite Nanocomposites as a Multifunctional Antioxidant and Anticancer Therapeutic Applications
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compositionsupports
The reported nanocomposite consists of zinc-substituted hydroxyapatite functionalized or loaded with Catharanthus roseus extract.
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evaluation methodsupports
The study evaluated the material using structural characterization, DPPH antioxidant assay, antibacterial testing against Staphylococcus aureus and Escherichia coli, and MTT cytotoxicity testing in MG-63/HOS osteosarcoma cells.
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paper scopesupports
The paper reports Catharanthus roseus extract-loaded zinc-substituted hydroxyapatite nanocomposites for multifunctional antioxidant and anticancer therapeutic applications.
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Comparisons
Source-stated alternatives
Nearby alternatives mentioned in the source-discovery scaffold include zinc-substituted hydroxyapatite materials without Catharanthus roseus loading and other zinc-based plant-assisted nanomaterials.
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Nearby alternatives mentioned in the source-discovery scaffold include zinc-substituted hydroxyapatite materials without Catharanthus roseus loading and other zinc-based plant-assisted nanomaterials.
Source-backed strengths
multifunctional therapeutic framing; evaluated across structural characterization, antioxidant, antibacterial, and cytotoxicity assays
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multifunctional therapeutic framing
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evaluated across structural characterization, antioxidant, antibacterial, and cytotoxicity assays
Compared with zinc-substituted hydroxyapatite
Nearby alternatives mentioned in the source-discovery scaffold include zinc-substituted hydroxyapatite materials without Catharanthus roseus loading and other zinc-based plant-assisted nanomaterials.
Shared frame: source-stated alternative in extracted literature
Strengths here: multifunctional therapeutic framing; evaluated across structural characterization, antioxidant, antibacterial, and cytotoxicity assays.
Relative tradeoffs: available evidence here does not support quantitative performance values; evidence here is limited to source metadata and upstream summary rather than direct abstract text.
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Nearby alternatives mentioned in the source-discovery scaffold include zinc-substituted hydroxyapatite materials without Catharanthus roseus loading and other zinc-based plant-assisted nanomaterials.
Ranked Citations
- 1.