Source 1primary paper2020Crystals
Toolkit/coherent anti-Stokes Raman scattering
coherent anti-Stokes Raman scattering
Also known as: CARS
Taxonomy: Technique Branch / Method. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
the key roles of RS in modern technologies of structure-based drug design are the detection and imaging of membrane protein microcrystals with the help of coherent anti-Stokes Raman scattering (CARS)
Usefulness & Problems
Why this is useful
CARS is described as a Raman modality used to detect and image membrane protein microcrystals.; detection of membrane protein microcrystals; imaging of membrane protein microcrystals; supporting protein structural crystallography
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CARS is described as a Raman modality used to detect and image membrane protein microcrystals.
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detection of membrane protein microcrystals
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imaging of membrane protein microcrystals
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supporting protein structural crystallography
Problem solved
The abstract links CARS-based microcrystal imaging to advancing protein structural crystallography and enabling new high-resolution membrane-protein structures.; helps detect and image membrane protein microcrystals in structure-based drug design workflows
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The abstract links CARS-based microcrystal imaging to advancing protein structural crystallography and enabling new high-resolution membrane-protein structures.
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helps detect and image membrane protein microcrystals in structure-based drug design workflows
Problem links
helps detect and image membrane protein microcrystals in structure-based drug design workflows
LiteratureThe abstract links CARS-based microcrystal imaging to advancing protein structural crystallography and enabling new high-resolution membrane-protein structures.
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The abstract links CARS-based microcrystal imaging to advancing protein structural crystallography and enabling new high-resolution membrane-protein structures.
Taxonomy & Function
Primary hierarchy
Technique Branch
Method: A concrete measurement method used to characterize an engineered system.
Target processes
No target processes tagged yet.
Input: Chemical
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: sensor
Operational role: sensor. Implementation mode: genetically encoded. Cofactor status: cofactor requirement unknown. Primary input modality: chemical.
The abstract does not provide evidence about whether CARS alone determines structure or replaces downstream crystallographic analysis.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Coherent anti-Stokes Raman scattering can detect and image membrane protein microcrystals for structure-based drug design and protein structural crystallography.
Structural studies of photoactive membrane proteins are relevant to development of new optogenetic tools.
Raman spectroscopy is a powerful method linking fundamental structural biology to medical applications.
Spontaneous, stimulated, resonant, surface-enhanced, and tip-enhanced Raman spectroscopy have biomedical applications.
Approval Evidence
1 source1 linked approval claimfirst-pass slug coherent-anti-stokes-raman-scattering
the key roles of RS in modern technologies of structure-based drug design are the detection and imaging of membrane protein microcrystals with the help of coherent anti-Stokes Raman scattering (CARS)
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applicationsupports
Coherent anti-Stokes Raman scattering can detect and image membrane protein microcrystals for structure-based drug design and protein structural crystallography.
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Comparisons
Source-backed strengths
explicitly linked to membrane protein microcrystal detection and imaging
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explicitly linked to membrane protein microcrystal detection and imaging
Compared with chronoamperometry
coherent anti-Stokes Raman scattering and chronoamperometry address a similar problem space.
Shared frame: same top-level item type; same primary input modality: chemical
Compared with multicomponent, ligand-functionalized microarrays
coherent anti-Stokes Raman scattering and multicomponent, ligand-functionalized microarrays address a similar problem space.
Shared frame: same top-level item type; same primary input modality: chemical
Compared with solid phase extraction
coherent anti-Stokes Raman scattering and solid phase extraction address a similar problem space.
Shared frame: same top-level item type; same primary input modality: chemical
Ranked Citations
- 1.