Source 1primary paper2026MED
Toolkit/cyp-14A5 promoter
cyp-14A5 promoter
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
The cyp-14A5 promoter is a light-responsive Caenorhabditis elegans promoter used as a construct element for visible light-inducible transcription. In the cited study, it drove ectopic gene expression in non-neuronal tissues and enabled induction of synthetic light-induced sleep and rapid aging phenotypes.
Usefulness & Problems
Why this is useful
This promoter is useful as a genetically encoded light-input module for controlling transgene expression in C. elegans. The available evidence indicates utility for experimentally linking light exposure to induced physiological and behavioral phenotypes through promoter-driven ectopic expression.
Source:
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression, causing synthetic light-induced sleep and rapid aging phenotypes in C. elegans
Source:
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression ... offer a new genetic tool for visible light-inducible gene expression in non-neuronal tissues
Problem solved
It addresses the need for a light-responsive promoter that can couple visible light exposure to transgene expression in non-neuronal C. elegans tissues. The cited application specifically used this control element to trigger synthetic sleep and rapid aging phenotypes.
Source:
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression, causing synthetic light-induced sleep and rapid aging phenotypes in C. elegans
Problem links
provides a genetic tool for visible light-inducible expression outside the visual system
LiteratureIt provides a way to induce gene expression with visible light in a non-visual, non-neuronal context. This addresses the need for a light-inducible genetic control element in C. elegans.
Source:
It provides a way to induce gene expression with visible light in a non-visual, non-neuronal context. This addresses the need for a light-inducible genetic control element in C. elegans.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A reusable architecture pattern for arranging parts into an engineered system.
Mechanisms
light-inducible transcriptional regulationpromoter-mediated control of ectopic gene expressionTechniques
No technique tags yet.
Target processes
No target processes tagged yet.
Input: Light
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationimplementation constraint: spectral hardware requirementoperating role: actuator
The available evidence supports use of the cyp-14A5 promoter as a promoter element to drive ectopic transgene expression in C. elegans, including in non-neuronal tissues. The input modality is visible light, but the supplied evidence does not specify construct architecture, promoter length, illumination parameters, or delivery and expression details.
Evidence is currently limited to a single cited study and a narrow application context. Quantitative properties such as induction kinetics, dynamic range, tissue specificity, basal leakiness, reversibility, and wavelength dependence are not provided in the supplied evidence.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Using the light-responsive cyp-14A5 promoter to drive ectopic gene expression can cause synthetic light-induced sleep and rapid aging phenotypes in C. elegans.
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression, causing synthetic light-induced sleep and rapid aging phenotypes in C. elegans
Using the light-responsive cyp-14A5 promoter to drive ectopic gene expression can cause synthetic light-induced sleep and rapid aging phenotypes in C. elegans.
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression, causing synthetic light-induced sleep and rapid aging phenotypes in C. elegans
Using the light-responsive cyp-14A5 promoter to drive ectopic gene expression can cause synthetic light-induced sleep and rapid aging phenotypes in C. elegans.
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression, causing synthetic light-induced sleep and rapid aging phenotypes in C. elegans
Using the light-responsive cyp-14A5 promoter to drive ectopic gene expression can cause synthetic light-induced sleep and rapid aging phenotypes in C. elegans.
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression, causing synthetic light-induced sleep and rapid aging phenotypes in C. elegans
Using the light-responsive cyp-14A5 promoter to drive ectopic gene expression can cause synthetic light-induced sleep and rapid aging phenotypes in C. elegans.
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression, causing synthetic light-induced sleep and rapid aging phenotypes in C. elegans
Using the light-responsive cyp-14A5 promoter to drive ectopic gene expression can cause synthetic light-induced sleep and rapid aging phenotypes in C. elegans.
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression, causing synthetic light-induced sleep and rapid aging phenotypes in C. elegans
Using the light-responsive cyp-14A5 promoter to drive ectopic gene expression can cause synthetic light-induced sleep and rapid aging phenotypes in C. elegans.
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression, causing synthetic light-induced sleep and rapid aging phenotypes in C. elegans
Using the light-responsive cyp-14A5 promoter to drive ectopic gene expression can cause synthetic light-induced sleep and rapid aging phenotypes in C. elegans.
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression, causing synthetic light-induced sleep and rapid aging phenotypes in C. elegans
The light-responsive cyp-14A5 promoter can be used to drive ectopic gene expression and is presented as a visible light-inducible genetic tool in non-neuronal tissues.
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression ... offer a new genetic tool for visible light-inducible gene expression in non-neuronal tissues
The light-responsive cyp-14A5 promoter can be used to drive ectopic gene expression and is presented as a visible light-inducible genetic tool in non-neuronal tissues.
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression ... offer a new genetic tool for visible light-inducible gene expression in non-neuronal tissues
The light-responsive cyp-14A5 promoter can be used to drive ectopic gene expression and is presented as a visible light-inducible genetic tool in non-neuronal tissues.
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression ... offer a new genetic tool for visible light-inducible gene expression in non-neuronal tissues
The light-responsive cyp-14A5 promoter can be used to drive ectopic gene expression and is presented as a visible light-inducible genetic tool in non-neuronal tissues.
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression ... offer a new genetic tool for visible light-inducible gene expression in non-neuronal tissues
The light-responsive cyp-14A5 promoter can be used to drive ectopic gene expression and is presented as a visible light-inducible genetic tool in non-neuronal tissues.
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression ... offer a new genetic tool for visible light-inducible gene expression in non-neuronal tissues
The light-responsive cyp-14A5 promoter can be used to drive ectopic gene expression and is presented as a visible light-inducible genetic tool in non-neuronal tissues.
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression ... offer a new genetic tool for visible light-inducible gene expression in non-neuronal tissues
The light-responsive cyp-14A5 promoter can be used to drive ectopic gene expression and is presented as a visible light-inducible genetic tool in non-neuronal tissues.
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression ... offer a new genetic tool for visible light-inducible gene expression in non-neuronal tissues
The light-responsive cyp-14A5 promoter can be used to drive ectopic gene expression and is presented as a visible light-inducible genetic tool in non-neuronal tissues.
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression ... offer a new genetic tool for visible light-inducible gene expression in non-neuronal tissues
Approval Evidence
1 source2 linked approval claimsfirst-pass slug cyp-14a5-promoter
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression ... offer a new genetic tool for visible light-inducible gene expression in non-neuronal tissues
Source:
application effectsupports
Using the light-responsive cyp-14A5 promoter to drive ectopic gene expression can cause synthetic light-induced sleep and rapid aging phenotypes in C. elegans.
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression, causing synthetic light-induced sleep and rapid aging phenotypes in C. elegans
Source:
tool capabilitysupports
The light-responsive cyp-14A5 promoter can be used to drive ectopic gene expression and is presented as a visible light-inducible genetic tool in non-neuronal tissues.
we use the light-responsive cyp-14A5 promoter to drive ectopic gene expression ... offer a new genetic tool for visible light-inducible gene expression in non-neuronal tissues
Source:
Comparisons
Source-stated alternatives
The abstract contrasts this pathway with known blue light receptors LITE-1 and GUR-3, which are reported not to mediate this induction. No alternative inducible promoter tool is explicitly described in the abstract.
Source:
The abstract contrasts this pathway with known blue light receptors LITE-1 and GUR-3, which are reported not to mediate this induction. No alternative inducible promoter tool is explicitly described in the abstract.
Source-backed strengths
The reported strength is direct light-inducible control of transcription from a native C. elegans promoter element. In the cited study, this was sufficient to produce clear organism-level phenotypes, including synthetic light-induced sleep and rapid aging.
Compared with mMORp
cyp-14A5 promoter and mMORp address a similar problem space.
Shared frame: same top-level item type; same primary input modality: light
Compared with optogenetic probes
cyp-14A5 promoter and optogenetic probes address a similar problem space.
Shared frame: same top-level item type; same primary input modality: light
Compared with organoid fusion
cyp-14A5 promoter and organoid fusion address a similar problem space.
Shared frame: same top-level item type; same primary input modality: light
Ranked Citations
- 1.