Source 1primary paper2025MED
Toolkit/frequency-adjustable ferroelectric heterojunction
frequency-adjustable ferroelectric heterojunction
Also known as: f-FH
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Here, we design and fabricate a frequency-adjustable ferroelectric heterojunction based on the developed K0.5Na0.5NbO3 piezoelectric ceramics...
Usefulness & Problems
Why this is useful
This device is a frequency-adjustable ferroelectric heterojunction that generates ultrasound for implantable transcranial neuromodulation. The abstract reports focal depth, focal width, and continuous focal tuning through the rat skull.; implantable ultrasound generation; transcranial neuromodulation; biomedical applications requiring focal tuning
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This device is a frequency-adjustable ferroelectric heterojunction that generates ultrasound for implantable transcranial neuromodulation. The abstract reports focal depth, focal width, and continuous focal tuning through the rat skull.
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implantable ultrasound generation
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transcranial neuromodulation
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biomedical applications requiring focal tuning
Problem solved
It addresses the need for a lead-free, miniaturized, implantable ultrasound source for precise brain modulation and related biomedical applications. The paper frames it as an alternative to lead-containing piezoelectric systems.; provides a lead-free implantable ferroelectric heterojunction for focused ultrasound applications; enables frequency-adjustable focal tuning through the rat skull
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It addresses the need for a lead-free, miniaturized, implantable ultrasound source for precise brain modulation and related biomedical applications. The paper frames it as an alternative to lead-containing piezoelectric systems.
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provides a lead-free implantable ferroelectric heterojunction for focused ultrasound applications
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enables frequency-adjustable focal tuning through the rat skull
Problem links
enables frequency-adjustable focal tuning through the rat skull
LiteratureIt addresses the need for a lead-free, miniaturized, implantable ultrasound source for precise brain modulation and related biomedical applications. The paper frames it as an alternative to lead-containing piezoelectric systems.
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It addresses the need for a lead-free, miniaturized, implantable ultrasound source for precise brain modulation and related biomedical applications. The paper frames it as an alternative to lead-containing piezoelectric systems.
provides a lead-free implantable ferroelectric heterojunction for focused ultrasound applications
LiteratureIt addresses the need for a lead-free, miniaturized, implantable ultrasound source for precise brain modulation and related biomedical applications. The paper frames it as an alternative to lead-containing piezoelectric systems.
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It addresses the need for a lead-free, miniaturized, implantable ultrasound source for precise brain modulation and related biomedical applications. The paper frames it as an alternative to lead-containing piezoelectric systems.
Published Workflows
Objective: Design and fabricate a lead-free, miniaturized, implantable frequency-adjustable ferroelectric heterojunction for transcranial neuromodulation and therapeutic use in a myocardial infarction animal model.
Why it works: The workflow combines high-performance lead-free K0.5Na0.5NbO3 piezoelectric ceramics with flexible encapsulation to produce a miniaturized implantable heterojunction whose acoustic output can be tuned for focused transcranial neuromodulation.
ultrasound generation through the rat skulltranscranial neuromodulationdevice designdevice fabricationflexible encapsulationimplantationacoustic characterizationanimal application testing
Stages
- 1.Device design and fabrication(library_build)
This stage creates the core heterojunction device using the reported KNN ceramic platform.
Selection: Construction of a frequency-adjustable ferroelectric heterojunction based on developed K0.5Na0.5NbO3 piezoelectric ceramics.
- 2.Miniaturization and implantability engineering(secondary_characterization)
This stage adapts the device for implantation by reducing size and adding flexible encapsulation.
Selection: Flexible encapsulation was used to achieve miniaturization and suitability for implantation.
- 3.Trans-skull acoustic characterization(functional_characterization)
This stage verifies that the implantable device can generate focused and tunable ultrasound through the rat skull before downstream biological application.
Selection: Acoustic performance after penetrating the rat skull was assessed by focal depth, focal width, and focal tuning.
- 4.In vivo neuromodulation and therapeutic testing(in_vivo_validation)
This stage validates that the device's acoustic performance translates into in vivo neuromodulation and disease-relevant benefit.
Selection: Implanted heterojunction was tested for long-term and high-precision transcranial neuromodulation and therapeutic effects in a myocardial infarction animal model.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A reusable architecture pattern for arranging parts into an engineered system.
Techniques
Computational DesignTarget processes
No target processes tagged yet.
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: actuator
The device is based on K0.5Na0.5NbO3 piezoelectric ceramics and flexible encapsulation. Its reported use involves implantation and ultrasound operation around 3 MHz.; built from K0.5Na0.5NbO3 piezoelectric ceramics; uses flexible encapsulation; intended for implantation
The abstract does not establish human clinical performance or broad operating ranges beyond the reported narrow frequency window. It also does not detail manufacturing scalability or long-term safety beyond the stated animal use.; reported evidence is in rat models; focal tuning is described within a narrow frequency range of 2.7-3.3 MHz
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
After penetrating the rat skull, the heterojunction generated ultrasound at 3 MHz with about 7.9 mm focal depth and approximately 480 μcm focal width at -6 dB.
focal depth 7.9 mmfocal width 480 μcmultrasound frequency 3 MHz
The heterojunction supported millimeter-scale continuous focal tuning of 1.5 mm within a narrow frequency range of 2.7-3.3 MHz.
continuous focal tuning range 1.5 mmfrequency range 2.7-3.3 MHz
The implanted heterojunction enabled long-term and high-precision transcranial neuromodulation and yielded therapeutic effects in a myocardial infarction animal model.
Flexible encapsulation enabled miniaturization of the ferroelectric heterojunction and suitability for implantation.
device diameter 13.3 mmdevice height 2.28 mm
The frequency-adjustable ferroelectric heterojunction is based on lead-free K0.5Na0.5NbO3 piezoelectric ceramics with a reported piezoelectric coefficient d33 of 680 pC/N.
piezoelectric coefficient d33 680 pC/N
Approval Evidence
1 source5 linked approval claimsfirst-pass slug frequency-adjustable-ferroelectric-heterojunction
Here, we design and fabricate a frequency-adjustable ferroelectric heterojunction based on the developed K0.5Na0.5NbO3 piezoelectric ceramics...
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acoustic performancesupports
After penetrating the rat skull, the heterojunction generated ultrasound at 3 MHz with about 7.9 mm focal depth and approximately 480 μcm focal width at -6 dB.
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acoustic performancesupports
The heterojunction supported millimeter-scale continuous focal tuning of 1.5 mm within a narrow frequency range of 2.7-3.3 MHz.
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application resultsupports
The implanted heterojunction enabled long-term and high-precision transcranial neuromodulation and yielded therapeutic effects in a myocardial infarction animal model.
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device propertysupports
Flexible encapsulation enabled miniaturization of the ferroelectric heterojunction and suitability for implantation.
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device propertysupports
The frequency-adjustable ferroelectric heterojunction is based on lead-free K0.5Na0.5NbO3 piezoelectric ceramics with a reported piezoelectric coefficient d33 of 680 pC/N.
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Comparisons
Source-stated alternatives
The abstract contrasts the KNN-based lead-free platform with lead-containing piezoelectric counterparts. No specific alternative implantable device architecture is described in the abstract.
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The abstract contrasts the KNN-based lead-free platform with lead-containing piezoelectric counterparts. No specific alternative implantable device architecture is described in the abstract.
Source-backed strengths
lead-free design; miniaturized and suitable for implantation; supports continuous focal tuning within a narrow frequency range; enabled long-term and high-precision transcranial neuromodulation in rats
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lead-free design
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miniaturized and suitable for implantation
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supports continuous focal tuning within a narrow frequency range
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enabled long-term and high-precision transcranial neuromodulation in rats
Compared with hemisynthetic thiostrepton analogues
frequency-adjustable ferroelectric heterojunction and hemisynthetic thiostrepton analogues address a similar problem space.
Shared frame: same top-level item type
Compared with mMORp
frequency-adjustable ferroelectric heterojunction and mMORp address a similar problem space.
Shared frame: same top-level item type
Strengths here: looks easier to implement in practice.
Compared with split-ring metamaterial sensor with luxuriant gaps
frequency-adjustable ferroelectric heterojunction and split-ring metamaterial sensor with luxuriant gaps address a similar problem space.
Shared frame: same top-level item type
Ranked Citations
- 1.