Source 1review2020Trends in Cardiovascular Medicine
Toolkit/ganglionated plexi ablation
ganglionated plexi ablation
Also known as: ganglionated plexus ablation, GP ablation
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Among them, techniques of cardiac sympathetic denervation, renal denervation, vagal stimulation, ganglionated plexi ablation and the newer experimental method of optogenetics have been employed.
Usefulness & Problems
Why this is useful
Ganglionated plexi ablation is described as an intervention that modulates autonomic inputs relevant to cardiac arrhythmias.; autonomic modulation for prevention and management of cardiac arrhythmias
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Ganglionated plexi ablation is described as an intervention that modulates autonomic inputs relevant to cardiac arrhythmias.
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autonomic modulation for prevention and management of cardiac arrhythmias
Problem solved
It is used as part of autonomic strategies for arrhythmia prevention and management.; targeting autonomic cardiac control sites in arrhythmia management
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It is used as part of autonomic strategies for arrhythmia prevention and management.
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targeting autonomic cardiac control sites in arrhythmia management
Problem links
targeting autonomic cardiac control sites in arrhythmia management
LiteratureIt is used as part of autonomic strategies for arrhythmia prevention and management.
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It is used as part of autonomic strategies for arrhythmia prevention and management.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A reusable architecture pattern for arranging parts into an engineered system.
Techniques
No technique tags yet.
Target processes
No target processes tagged yet.
Input: Light
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationimplementation constraint: spectral hardware requirementoperating role: actuator
The abstract supports that this is an ablation-based procedure directed at ganglionated plexi.; requires an ablation procedure targeting ganglionated plexi
The abstract does not establish definitive efficacy across disease settings and notes that many ANS-modulating interventions remain investigational.; ANS modulation remains investigational in many arrhythmogenic diseases; further efficacy studies are needed
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
In many arrhythmogenic diseases, autonomic nervous system modulation remains investigational, with encouraging initial data but a need for further efficacy studies.
However, in many arrhythmogenic diseases, ANS modulation is still an investigative tool. Initial data are encouraging; however, further studies are needed to explore the efficacy of such interventions.
Cardiac sympathetic denervation, renal denervation, vagal stimulation, ganglionated plexi ablation, and optogenetics are intervention classes that have been employed for autonomic modulation in arrhythmia prevention and management.
Over the years, in addition to classical drug therapies, where beta-blockers prevail, several ANS-modulating interventions have been developed aiming at prevention and management of arrhythmias. Among them, techniques of cardiac sympathetic denervation, renal denervation, vagal stimulation, ganglionated plexi ablation and the newer experimental method of optogenetics have been employed.
Approval Evidence
1 source2 linked approval claimsfirst-pass slug ganglionated-plexi-ablation
Among them, techniques of cardiac sympathetic denervation, renal denervation, vagal stimulation, ganglionated plexi ablation and the newer experimental method of optogenetics have been employed.
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evidence maturitysupports
In many arrhythmogenic diseases, autonomic nervous system modulation remains investigational, with encouraging initial data but a need for further efficacy studies.
However, in many arrhythmogenic diseases, ANS modulation is still an investigative tool. Initial data are encouraging; however, further studies are needed to explore the efficacy of such interventions.
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intervention landscapesupports
Cardiac sympathetic denervation, renal denervation, vagal stimulation, ganglionated plexi ablation, and optogenetics are intervention classes that have been employed for autonomic modulation in arrhythmia prevention and management.
Over the years, in addition to classical drug therapies, where beta-blockers prevail, several ANS-modulating interventions have been developed aiming at prevention and management of arrhythmias. Among them, techniques of cardiac sympathetic denervation, renal denervation, vagal stimulation, ganglionated plexi ablation and the newer experimental method of optogenetics have been employed.
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Comparisons
Source-stated alternatives
Named alternatives include beta-blockers, cardiac sympathetic denervation, renal denervation, vagal stimulation, and optogenetics.
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Named alternatives include beta-blockers, cardiac sympathetic denervation, renal denervation, vagal stimulation, and optogenetics.
Source-backed strengths
identified as a developed ANS-modulating intervention
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identified as a developed ANS-modulating intervention
Compared with optogenetic functional interrogation
Named alternatives include beta-blockers, cardiac sympathetic denervation, renal denervation, vagal stimulation, and optogenetics.
Shared frame: source-stated alternative in extracted literature
Strengths here: identified as a developed ANS-modulating intervention.
Relative tradeoffs: ANS modulation remains investigational in many arrhythmogenic diseases; further efficacy studies are needed.
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Named alternatives include beta-blockers, cardiac sympathetic denervation, renal denervation, vagal stimulation, and optogenetics.
Compared with optogenetic membrane potential perturbation
Named alternatives include beta-blockers, cardiac sympathetic denervation, renal denervation, vagal stimulation, and optogenetics.
Shared frame: source-stated alternative in extracted literature
Strengths here: identified as a developed ANS-modulating intervention.
Relative tradeoffs: ANS modulation remains investigational in many arrhythmogenic diseases; further efficacy studies are needed.
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Named alternatives include beta-blockers, cardiac sympathetic denervation, renal denervation, vagal stimulation, and optogenetics.
Compared with vagal stimulation
Named alternatives include beta-blockers, cardiac sympathetic denervation, renal denervation, vagal stimulation, and optogenetics.
Shared frame: source-stated alternative in extracted literature
Strengths here: identified as a developed ANS-modulating intervention.
Relative tradeoffs: ANS modulation remains investigational in many arrhythmogenic diseases; further efficacy studies are needed.
Source:
Named alternatives include beta-blockers, cardiac sympathetic denervation, renal denervation, vagal stimulation, and optogenetics.
Ranked Citations
- 1.