Source 1review2020Trends in Cardiovascular Medicine
Toolkit/vagal stimulation
vagal stimulation
Also known as: vagus nerve stimulation, VNS
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Among them, techniques of cardiac sympathetic denervation, renal denervation, vagal stimulation, ganglionated plexi ablation and the newer experimental method of optogenetics have been employed.
Usefulness & Problems
Why this is useful
Vagal stimulation is presented as an ANS-modulating intervention used to influence cardiac rhythm control.; autonomic modulation for prevention and management of cardiac arrhythmias
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Vagal stimulation is presented as an ANS-modulating intervention used to influence cardiac rhythm control.
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autonomic modulation for prevention and management of cardiac arrhythmias
Problem solved
It is used in attempts to prevent or manage arrhythmias through autonomic modulation.; modulating parasympathetic influence in arrhythmia management
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It is used in attempts to prevent or manage arrhythmias through autonomic modulation.
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modulating parasympathetic influence in arrhythmia management
Problem links
modulating parasympathetic influence in arrhythmia management
LiteratureIt is used in attempts to prevent or manage arrhythmias through autonomic modulation.
Source:
It is used in attempts to prevent or manage arrhythmias through autonomic modulation.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A reusable architecture pattern for arranging parts into an engineered system.
Mechanisms
autonomic nervous system modulationTechniques
No technique tags yet.
Target processes
No target processes tagged yet.
Input: Light
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationimplementation constraint: spectral hardware requirementoperating role: actuator
The abstract supports that this approach requires stimulation of the vagal arm of the autonomic nervous system.; requires a stimulation-based neuromodulation intervention
The review also notes that parasympathetic overactivity can trigger vagotonic arrhythmias, so vagal-axis modulation is not presented as uniformly protective.; parasympathetic overactivity may itself trigger vagotonic arrhythmias; ANS modulation remains investigational in many diseases; further efficacy studies are needed
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
In many arrhythmogenic diseases, autonomic nervous system modulation remains investigational, with encouraging initial data but a need for further efficacy studies.
However, in many arrhythmogenic diseases, ANS modulation is still an investigative tool. Initial data are encouraging; however, further studies are needed to explore the efficacy of such interventions.
Cardiac sympathetic denervation, renal denervation, vagal stimulation, ganglionated plexi ablation, and optogenetics are intervention classes that have been employed for autonomic modulation in arrhythmia prevention and management.
Over the years, in addition to classical drug therapies, where beta-blockers prevail, several ANS-modulating interventions have been developed aiming at prevention and management of arrhythmias. Among them, techniques of cardiac sympathetic denervation, renal denervation, vagal stimulation, ganglionated plexi ablation and the newer experimental method of optogenetics have been employed.
Approval Evidence
1 source2 linked approval claimsfirst-pass slug vagal-stimulation
Among them, techniques of cardiac sympathetic denervation, renal denervation, vagal stimulation, ganglionated plexi ablation and the newer experimental method of optogenetics have been employed.
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evidence maturitysupports
In many arrhythmogenic diseases, autonomic nervous system modulation remains investigational, with encouraging initial data but a need for further efficacy studies.
However, in many arrhythmogenic diseases, ANS modulation is still an investigative tool. Initial data are encouraging; however, further studies are needed to explore the efficacy of such interventions.
Source:
intervention landscapesupports
Cardiac sympathetic denervation, renal denervation, vagal stimulation, ganglionated plexi ablation, and optogenetics are intervention classes that have been employed for autonomic modulation in arrhythmia prevention and management.
Over the years, in addition to classical drug therapies, where beta-blockers prevail, several ANS-modulating interventions have been developed aiming at prevention and management of arrhythmias. Among them, techniques of cardiac sympathetic denervation, renal denervation, vagal stimulation, ganglionated plexi ablation and the newer experimental method of optogenetics have been employed.
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Comparisons
Source-stated alternatives
The abstract names beta-blockers, cardiac sympathetic denervation, renal denervation, ganglionated plexi ablation, and optogenetics as other approaches.
Source:
The abstract names beta-blockers, cardiac sympathetic denervation, renal denervation, ganglionated plexi ablation, and optogenetics as other approaches.
Source-backed strengths
identified as a developed ANS-modulating intervention
Source:
identified as a developed ANS-modulating intervention
Compared with ganglionated plexi ablation
The abstract names beta-blockers, cardiac sympathetic denervation, renal denervation, ganglionated plexi ablation, and optogenetics as other approaches.
Shared frame: source-stated alternative in extracted literature
Strengths here: identified as a developed ANS-modulating intervention.
Relative tradeoffs: parasympathetic overactivity may itself trigger vagotonic arrhythmias; ANS modulation remains investigational in many diseases; further efficacy studies are needed.
Source:
The abstract names beta-blockers, cardiac sympathetic denervation, renal denervation, ganglionated plexi ablation, and optogenetics as other approaches.
Compared with optogenetic functional interrogation
The abstract names beta-blockers, cardiac sympathetic denervation, renal denervation, ganglionated plexi ablation, and optogenetics as other approaches.
Shared frame: source-stated alternative in extracted literature
Strengths here: identified as a developed ANS-modulating intervention.
Relative tradeoffs: parasympathetic overactivity may itself trigger vagotonic arrhythmias; ANS modulation remains investigational in many diseases; further efficacy studies are needed.
Source:
The abstract names beta-blockers, cardiac sympathetic denervation, renal denervation, ganglionated plexi ablation, and optogenetics as other approaches.
Compared with optogenetic membrane potential perturbation
The abstract names beta-blockers, cardiac sympathetic denervation, renal denervation, ganglionated plexi ablation, and optogenetics as other approaches.
Shared frame: source-stated alternative in extracted literature
Strengths here: identified as a developed ANS-modulating intervention.
Relative tradeoffs: parasympathetic overactivity may itself trigger vagotonic arrhythmias; ANS modulation remains investigational in many diseases; further efficacy studies are needed.
Source:
The abstract names beta-blockers, cardiac sympathetic denervation, renal denervation, ganglionated plexi ablation, and optogenetics as other approaches.
Ranked Citations
- 1.