Source 1review2021Frontiers in Physiology
Toolkit/implantable optical devices
implantable optical devices
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Implantable optical devices are being extensively developed to study particular electrophysiological phenomena with the precise control that optogenetics provides.
Usefulness & Problems
Why this is useful
Implantable optical devices are described as hardware being developed for optogenetic study of cardiac electrophysiological phenomena. They serve as the light-delivery interface for precise control in cardiovascular research.; implantable light delivery in cardiac optogenetics; studying electrophysiological phenomena with precise optical control
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Implantable optical devices are described as hardware being developed for optogenetic study of cardiac electrophysiological phenomena. They serve as the light-delivery interface for precise control in cardiovascular research.
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implantable light delivery in cardiac optogenetics
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studying electrophysiological phenomena with precise optical control
Problem solved
They address the need to bring precise optical stimulation into implanted cardiovascular research settings. This makes optogenetic control more directly usable for cardiac studies.; provides a hardware route for delivering optogenetic control in cardiovascular settings
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They address the need to bring precise optical stimulation into implanted cardiovascular research settings. This makes optogenetic control more directly usable for cardiac studies.
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provides a hardware route for delivering optogenetic control in cardiovascular settings
Problem links
provides a hardware route for delivering optogenetic control in cardiovascular settings
LiteratureThey address the need to bring precise optical stimulation into implanted cardiovascular research settings. This makes optogenetic control more directly usable for cardiac studies.
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They address the need to bring precise optical stimulation into implanted cardiovascular research settings. This makes optogenetic control more directly usable for cardiac studies.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A delivery strategy grouped with the mechanism branch because it determines how a system is instantiated and deployed in context.
Techniques
No technique tags yet.
Target processes
translationInput: Light
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: externally suppliedimplementation constraint: context specific validationimplementation constraint: spectral hardware requirementoperating role: delivery
These devices require an optogenetic target system and implantation-compatible hardware. Their use is framed in animal cardiac research and prospective clinical translation.; requires compatibility with optogenetic systems; requires implantation in cardiovascular research settings
The abstract does not establish that current devices have solved clinical translation. Instead, it emphasizes ongoing translational difficulties.; translation toward clinical applications remains difficult
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Channelrhodopsin-2-based optogenetic approaches can offer low-energy and localized control.
Implantable optical devices are being extensively developed for studying cardiac electrophysiological phenomena with precise optogenetic control.
Translation of implantable optogenetic technology toward clinical cardiovascular applications remains difficult and requires potential solutions.
Approval Evidence
1 source2 linked approval claimsfirst-pass slug implantable-optical-devices
Implantable optical devices are being extensively developed to study particular electrophysiological phenomena with the precise control that optogenetics provides.
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technology development summarysupports
Implantable optical devices are being extensively developed for studying cardiac electrophysiological phenomena with precise optogenetic control.
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translation barrier summarysupports
Translation of implantable optogenetic technology toward clinical cardiovascular applications remains difficult and requires potential solutions.
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Comparisons
Source-stated alternatives
The abstract does not explicitly name alternative implant classes or non-implant optical systems. It only contrasts the field's earlier neurobiological focus with newer cardiac applications.
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The abstract does not explicitly name alternative implant classes or non-implant optical systems. It only contrasts the field's earlier neurobiological focus with newer cardiac applications.
Source-backed strengths
supports precise control enabled by optogenetics; positioned as feasible for cardiac research
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supports precise control enabled by optogenetics
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positioned as feasible for cardiac research
Compared with Adeno-associated virus
implantable optical devices and Adeno-associated virus address a similar problem space because they share translation.
Shared frame: same top-level item type; shared target processes: translation; shared mechanisms: translation_control; same primary input modality: light
Strengths here: may avoid an exogenous cofactor requirement.
Relative tradeoffs: appears more independently replicated; looks easier to implement in practice.
Compared with Deep Brain Stimulation
implantable optical devices and Deep Brain Stimulation address a similar problem space because they share translation.
Shared frame: same top-level item type; shared target processes: translation; shared mechanisms: translation_control; same primary input modality: light
Relative tradeoffs: appears more independently replicated; looks easier to implement in practice.
Compared with microfabricated LED cochlear implant
implantable optical devices and microfabricated LED cochlear implant address a similar problem space because they share translation.
Shared frame: same top-level item type; shared target processes: translation; shared mechanisms: translation_control; same primary input modality: light
Ranked Citations
- 1.