Source 1review2017Frontiers in Pharmacology
Toolkit/open-field locomotion
open-field locomotion
Taxonomy: Technique Branch / Method. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
behavioral measures in rodents, like prepulse inhibition of the acoustic startle and open-field locomotion, which are commonly used along with neurochemical approaches or drug challenge designs
Usefulness & Problems
Why this is useful
Open-field locomotion is presented as a common rodent behavioral measure in this research area. The abstract links such measures to mapping hyperlocomotion and related disturbances.; rodent behavioral assessment in schizophrenia-related studies; mapping hyperlocomotion-related phenotypes
Source:
Open-field locomotion is presented as a common rodent behavioral measure in this research area. The abstract links such measures to mapping hyperlocomotion and related disturbances.
Source:
rodent behavioral assessment in schizophrenia-related studies
Source:
mapping hyperlocomotion-related phenotypes
Problem solved
It provides a simple behavioral readout for schizophrenia-relevant locomotor phenotypes in cannabinoid studies. This helps map fundamental mechanisms associated with hyperlocomotion.; provides a behavioral readout for hyperlocomotion-related disturbances
Source:
It provides a simple behavioral readout for schizophrenia-relevant locomotor phenotypes in cannabinoid studies. This helps map fundamental mechanisms associated with hyperlocomotion.
Source:
provides a behavioral readout for hyperlocomotion-related disturbances
Problem links
provides a behavioral readout for hyperlocomotion-related disturbances
LiteratureIt provides a simple behavioral readout for schizophrenia-relevant locomotor phenotypes in cannabinoid studies. This helps map fundamental mechanisms associated with hyperlocomotion.
Source:
It provides a simple behavioral readout for schizophrenia-relevant locomotor phenotypes in cannabinoid studies. This helps map fundamental mechanisms associated with hyperlocomotion.
Published Workflows
Objective: Improve mechanistic and translational understanding of how cannabinoids and vanilloids influence schizophrenia-relevant phenotypes by combining psychopharmacological and neurophysiological tools.
Why it works: The review argues that existing behavioral and neurochemical strategies map important mechanisms but need neurophysiological tools to better inform clinical research, implying that combining these modalities improves mechanistic interpretation and translational value.
sensorimotor gatinghyperlocomotionsocial interactionmonoaminergic disturbancesglutamatergic disturbancesGABAergic disturbancesendocannabinoid-endovanilloid interplaybehavioral assaysneurochemical approachesdrug challenge designselectrophysiologyviral vector-based circuit dissectionoptogenetics
Stages
- 1.Rodent behavioral and neurochemical mapping(broad_screen)
This stage represents the established knowledge-generating base from which much of the field's understanding has been derived.
Selection: Use common rodent behavioral measures and associated neurochemical or drug challenge approaches to map schizophrenia-relevant mechanisms.
- 2.Human imaging and electrographic contextualization(functional_characterization)
The review explicitly begins by contextualizing human imaging and electrographic findings before discussing rodent electrophysiology.
- 3.Rodent electrophysiology review and mechanistic interpretation(secondary_characterization)
The review next presents rodent electrophysiology to deepen mechanistic understanding beyond behavioral readouts.
- 4.Combined psychopharmacological and neurophysiological future-direction integration(decision_gate)
This final stage captures the review's explicit recommendation for how the field should proceed.
Taxonomy & Function
Primary hierarchy
Technique Branch
Method: A concrete measurement method used to characterize an engineered system.
Target processes
No target processes tagged yet.
Input: Chemical
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationimplementation constraint: payload burdenoperating role: sensor
The abstract supports use in rodents and notes that these behavioral measures are commonly used with neurochemical approaches or drug challenge designs. No protocol details are given.; used in rodent behavioral studies; commonly paired with neurochemical approaches or drug challenge designs
The review states that behavioral strategies need stronger neurophysiological support to better inform clinical research. The abstract does not claim that open-field assays resolve circuit or synaptic mechanisms.; review states that these strategies require greater use of neurophysiological tools to better inform clinical research
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Behavioral and neurochemical strategies in this area require greater use of neurophysiological tools to better inform clinical research.
These strategies will require, however, a greater use of neurophysiological tools to better inform clinical research.
Electrophysiology and viral vector-based circuit dissection such as optogenetics can further elucidate how exogenous cannabinoids worsen or ameliorate schizophrenia symptoms.
electrophysiology and viral vector-based circuit dissection, like optogenetics, can further elucidate how exogenous cannabinoids worsen (e.g., tetrahydrocannabinol, THC) or ameliorate (e.g., cannabidiol, CBD) schizophrenia symptoms
Rodent behavioral measures such as prepulse inhibition and open-field locomotion, often combined with neurochemical approaches or drug challenge designs, have provided much of the field's knowledge about the endocannabinoid system in schizophrenia.
Much of our knowledge of the endocannabinoid system in schizophrenia comes from behavioral measures in rodents, like prepulse inhibition of the acoustic startle and open-field locomotion, which are commonly used along with neurochemical approaches or drug challenge designs.
Approval Evidence
1 source1 linked approval claimfirst-pass slug open-field-locomotion
behavioral measures in rodents, like prepulse inhibition of the acoustic startle and open-field locomotion, which are commonly used along with neurochemical approaches or drug challenge designs
Source:
review summarysupports
Rodent behavioral measures such as prepulse inhibition and open-field locomotion, often combined with neurochemical approaches or drug challenge designs, have provided much of the field's knowledge about the endocannabinoid system in schizophrenia.
Much of our knowledge of the endocannabinoid system in schizophrenia comes from behavioral measures in rodents, like prepulse inhibition of the acoustic startle and open-field locomotion, which are commonly used along with neurochemical approaches or drug challenge designs.
Source:
Comparisons
Source-stated alternatives
Prepulse inhibition, neurochemical approaches, and drug challenge designs are named as related strategies. Electrophysiology and optogenetics are presented as complementary tools.
Source:
Prepulse inhibition, neurochemical approaches, and drug challenge designs are named as related strategies. Electrophysiology and optogenetics are presented as complementary tools.
Source-backed strengths
described as commonly used in the field
Source:
described as commonly used in the field
Compared with electrophysiology
Prepulse inhibition, neurochemical approaches, and drug challenge designs are named as related strategies. Electrophysiology and optogenetics are presented as complementary tools.
Shared frame: source-stated alternative in extracted literature
Strengths here: described as commonly used in the field.
Relative tradeoffs: review states that these strategies require greater use of neurophysiological tools to better inform clinical research.
Source:
Prepulse inhibition, neurochemical approaches, and drug challenge designs are named as related strategies. Electrophysiology and optogenetics are presented as complementary tools.
Compared with optogenetic functional interrogation
Prepulse inhibition, neurochemical approaches, and drug challenge designs are named as related strategies. Electrophysiology and optogenetics are presented as complementary tools.
Shared frame: source-stated alternative in extracted literature
Strengths here: described as commonly used in the field.
Relative tradeoffs: review states that these strategies require greater use of neurophysiological tools to better inform clinical research.
Source:
Prepulse inhibition, neurochemical approaches, and drug challenge designs are named as related strategies. Electrophysiology and optogenetics are presented as complementary tools.
Compared with optogenetic membrane potential perturbation
Prepulse inhibition, neurochemical approaches, and drug challenge designs are named as related strategies. Electrophysiology and optogenetics are presented as complementary tools.
Shared frame: source-stated alternative in extracted literature
Strengths here: described as commonly used in the field.
Relative tradeoffs: review states that these strategies require greater use of neurophysiological tools to better inform clinical research.
Source:
Prepulse inhibition, neurochemical approaches, and drug challenge designs are named as related strategies. Electrophysiology and optogenetics are presented as complementary tools.
Ranked Citations
- 1.