Source 1review2015Neurophotonics
Toolkit/optrode
optrode
Also known as: optode, optrode
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
An optrode, also called an optode, is a neural probe that integrates conventional electrophysiological recording with one or more optical channels for optogenetic activation in live animals. It is used to deliver light to neural tissue while measuring electrical activity from the same preparation.
Usefulness & Problems
Why this is useful
This construct pattern is useful for experiments that require simultaneous optical perturbation and electrophysiological readout in vivo. The cited literature frames configuration choice as dependent on practical considerations and the biological question being addressed.
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An optrode is a neural probe that combines conventional electrophysiological recording with one or more optical channels for optogenetic activation in live animals.
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combining optogenetic activation with electrophysiological recording in live animals
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in vivo light delivery during neural recording
Problem solved
Optrodes address the need to stimulate neural tissue optically while recording electrophysiological signals from the same live-animal preparation. They therefore support combined manipulation-and-measurement experiments in optogenetics.
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It solves the need to stimulate neural tissue optically while recording electrophysiological signals from the same in vivo preparation.
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integrates optical stimulation channels with conventional electrophysiological probes for in vivo optogenetics applications
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addresses the need for light delivery devices when visible light penetration in tissue is limited
Problem links
addresses the need for light delivery devices when visible light penetration in tissue is limited
LiteratureIt solves the need to stimulate neural tissue optically while recording electrophysiological signals from the same in vivo preparation.
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It solves the need to stimulate neural tissue optically while recording electrophysiological signals from the same in vivo preparation.
integrates optical stimulation channels with conventional electrophysiological probes for in vivo optogenetics applications
LiteratureIt solves the need to stimulate neural tissue optically while recording electrophysiological signals from the same in vivo preparation.
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It solves the need to stimulate neural tissue optically while recording electrophysiological signals from the same in vivo preparation.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A reusable architecture pattern for arranging parts into an engineered system.
Techniques
Computational DesignTarget processes
No target processes tagged yet.
Input: Light
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationimplementation constraint: spectral hardware requirementoperating role: actuator
Implementation requires a probe architecture that combines electrophysiological recording elements with one or more light-delivery channels for in vivo optogenetics. The available evidence does not specify particular materials, wavelengths, opsins, fabrication methods, or animal species.
The provided evidence does not report quantitative performance metrics, comparative benchmarks, or specific validation outcomes for any single optrode design. The extraction notes additionally indicate that optrodes do not eliminate fundamental visible-light tissue penetration limits.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Choice of combined optogenetics-electrophysiology configuration is guided by practical considerations and by the questions one seeks to address.
Choice of combined optogenetics-electrophysiology configuration is guided by practical considerations and by the questions one seeks to address.
Choice of combined optogenetics-electrophysiology configuration is guided by practical considerations and by the questions one seeks to address.
Choice of combined optogenetics-electrophysiology configuration is guided by practical considerations and by the questions one seeks to address.
Choice of combined optogenetics-electrophysiology configuration is guided by practical considerations and by the questions one seeks to address.
Choice of combined optogenetics-electrophysiology configuration is guided by practical considerations and by the questions one seeks to address.
Choice of combined optogenetics-electrophysiology configuration is guided by practical considerations and by the questions one seeks to address.
Choice of combined optogenetics-electrophysiology configuration is guided by practical considerations and by the questions one seeks to address.
Choice of combined optogenetics-electrophysiology configuration is guided by practical considerations and by the questions one seeks to address.
Optodes or optrodes are neural probes that combine conventional electrophysiological recordings with optical channel or channels for optogenetic activation.
Optodes or optrodes are neural probes that combine conventional electrophysiological recordings with optical channel or channels for optogenetic activation.
Optodes or optrodes are neural probes that combine conventional electrophysiological recordings with optical channel or channels for optogenetic activation.
Optodes or optrodes are neural probes that combine conventional electrophysiological recordings with optical channel or channels for optogenetic activation.
Optodes or optrodes are neural probes that combine conventional electrophysiological recordings with optical channel or channels for optogenetic activation.
Optodes or optrodes are neural probes that combine conventional electrophysiological recordings with optical channel or channels for optogenetic activation.
Optodes or optrodes are neural probes that combine conventional electrophysiological recordings with optical channel or channels for optogenetic activation.
Optodes or optrodes are neural probes that combine conventional electrophysiological recordings with optical channel or channels for optogenetic activation.
Optodes or optrodes are neural probes that combine conventional electrophysiological recordings with optical channel or channels for optogenetic activation.
Because visible light penetration in tissue is limited, development of optogenetic tools was quickly followed by development of light-delivery devices for in vivo optogenetics applications.
Because visible light penetration in tissue is limited, development of optogenetic tools was quickly followed by development of light-delivery devices for in vivo optogenetics applications.
Because visible light penetration in tissue is limited, development of optogenetic tools was quickly followed by development of light-delivery devices for in vivo optogenetics applications.
Because visible light penetration in tissue is limited, development of optogenetic tools was quickly followed by development of light-delivery devices for in vivo optogenetics applications.
Because visible light penetration in tissue is limited, development of optogenetic tools was quickly followed by development of light-delivery devices for in vivo optogenetics applications.
Because visible light penetration in tissue is limited, development of optogenetic tools was quickly followed by development of light-delivery devices for in vivo optogenetics applications.
Because visible light penetration in tissue is limited, development of optogenetic tools was quickly followed by development of light-delivery devices for in vivo optogenetics applications.
Because visible light penetration in tissue is limited, development of optogenetic tools was quickly followed by development of light-delivery devices for in vivo optogenetics applications.
Because visible light penetration in tissue is limited, development of optogenetic tools was quickly followed by development of light-delivery devices for in vivo optogenetics applications.
Approval Evidence
1 source3 linked approval claimsfirst-pass slug optrode
We summarize the efforts made in the last decade to design neural probes that combine conventional electrophysiological recordings and optical channel(s) for optogenetic activation, often referred to as optodes or optrodes.
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configuration guidancesupports
Choice of combined optogenetics-electrophysiology configuration is guided by practical considerations and by the questions one seeks to address.
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definitionsupports
Optodes or optrodes are neural probes that combine conventional electrophysiological recordings with optical channel or channels for optogenetic activation.
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design rationalesupports
Because visible light penetration in tissue is limited, development of optogenetic tools was quickly followed by development of light-delivery devices for in vivo optogenetics applications.
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Comparisons
Source-stated alternatives
The abstract contrasts broad configuration choices and probe designs rather than naming a single alternative platform, emphasizing that selection depends on the experimental question.
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The abstract contrasts broad configuration choices and probe designs rather than naming a single alternative platform, emphasizing that selection depends on the experimental question.
Source-backed strengths
The core strength supported by the evidence is physical integration of optical channel(s) with conventional neural recording capability in a single probe format. The source literature also indicates that multiple combined optogenetics-electrophysiology configurations have been developed over the last decade.
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supports combined optical and electrophysiological functionality
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review discusses multiple probe designs and multimodality options
Compared with mMORp
optrode and mMORp address a similar problem space.
Shared frame: same top-level item type; same primary input modality: light
Compared with optogenetic probes
optrode and optogenetic probes address a similar problem space.
Shared frame: same top-level item type; same primary input modality: light
Compared with organoid fusion
optrode and organoid fusion address a similar problem space.
Shared frame: same top-level item type; same primary input modality: light
Ranked Citations
- 1.