Source 1review2021Cells
Toolkit/PACR
PACR
Also known as: PACR
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Web research summary identifies PACR as an explicitly identified alternative optogenetic Ca2+ release tool within the review topic.
Usefulness & Problems
No literature-backed usefulness or problem-fit explainer has been materialized for this record yet.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A composed arrangement of multiple parts that instantiates one or more mechanisms.
Techniques
No technique tags yet.
Target processes
signalingInput: Light
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Source 2review2017Cell Calcium
Ranked Claims
The review covers optogenetic tools for precise control of Ca2+-permeable ion channels, receptors, and associated downstream signaling cascades.
Here, we review the various optogenetic tools that have been used to achieve precise control over different Ca2+-permeable ion channels and receptors and associated downstream signaling cascades.
This review covers an optogenetic toolkit for precise control of calcium signaling, including genetically encoded calcium actuators and multiple mechanistic classes such as STIM1/CRAC-based, GPCR-based, RTK-based, and channel-based approaches.
Melanopsin and Opto-XRs are discussed in the review as GPCR-based optogenetic routes relevant to calcium signaling control.
Opto-RTKs are discussed in the review as receptor-tyrosine-kinase-based optogenetic tools within the calcium-control toolkit.
OptoSTIM1 and Opto-CRAC are discussed in the review as STIM1/CRAC-based optogenetic tools for controlling calcium signaling.
PACR is discussed in the review as a genetically encoded photoactivatable calcium releaser for optical control of calcium signaling.
Approval Evidence
2 sources3 linked approval claimsfirst-pass slug pacr
Web research summary identifies PACR as an explicitly identified alternative optogenetic Ca2+ release tool within the review topic.
Source:
The supplied review scaffold explicitly frames the space around genetically encoded Ca2+ actuators and names PACR as a photoactivatable Ca2+ releaser discussed in the anchor review.
Source:
review scope statementsupports
The review covers optogenetic tools for precise control of Ca2+-permeable ion channels, receptors, and associated downstream signaling cascades.
Here, we review the various optogenetic tools that have been used to achieve precise control over different Ca2+-permeable ion channels and receptors and associated downstream signaling cascades.
Source:
review scopesupports
This review covers an optogenetic toolkit for precise control of calcium signaling, including genetically encoded calcium actuators and multiple mechanistic classes such as STIM1/CRAC-based, GPCR-based, RTK-based, and channel-based approaches.
Source:
tool classificationsupports
PACR is discussed in the review as a genetically encoded photoactivatable calcium releaser for optical control of calcium signaling.
Source:
Comparisons
No literature-backed comparison notes have been materialized for this record yet.
Ranked Citations
- 1.
- 2.