Source 1review2017Chemical Society Reviews
Toolkit/photoresponsive oligonucleotide systems for drug delivery
photoresponsive oligonucleotide systems for drug delivery
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Additionally the applications that have emerged in recent years are discussed, including gene regulation, drug delivery and materials design.
Usefulness & Problems
Why this is useful
This application class uses photoresponsive oligonucleotide systems in drug delivery contexts. The review names drug delivery as one of the emerging application areas.; light-responsive drug delivery concepts
Source:
This application class uses photoresponsive oligonucleotide systems in drug delivery contexts. The review names drug delivery as one of the emerging application areas.
Source:
light-responsive drug delivery concepts
Problem solved
It aims to add external optical control to delivery-related oligonucleotide function.; supports optical control in drug-delivery-related oligonucleotide applications
Source:
It aims to add external optical control to delivery-related oligonucleotide function.
Source:
supports optical control in drug-delivery-related oligonucleotide applications
Problem links
supports optical control in drug-delivery-related oligonucleotide applications
LiteratureIt aims to add external optical control to delivery-related oligonucleotide function.
Source:
It aims to add external optical control to delivery-related oligonucleotide function.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A reusable architecture pattern for arranging parts into an engineered system.
Mechanisms
photoisomerization-based switching of oligonucleotide structure and functionreversible photoregulationTechniques
Computational DesignTarget processes
No target processes tagged yet.
Input: Light
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationimplementation constraint: spectral hardware requirementoperating role: actuator
It requires a light-responsive oligonucleotide design and a way to illuminate the system during use.; requires photoresponsive oligonucleotide designs; requires light access to actuate control
The abstract does not establish how delivery efficiency, tissue penetration, or therapeutic performance are handled.; the abstract does not specify delivery vehicles, cargos, or performance constraints
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Light-based photoregulation is attractive because it offers high spatiotemporal precision and is non-invasive and waste-free.
Emerging applications discussed in the review include gene regulation, drug delivery, and materials design.
The review identifies current challenges facing the field and considers future applications.
The field has progressed beyond fundamental studies of switch photochemistry and DNA duplex stability toward applications in chemical biology, nanotechnology, and material science.
The review presents key strategies for incorporating molecular photoswitches into oligonucleotides to reversibly photoregulate DNA and RNA structure and function.
Approval Evidence
1 source1 linked approval claimfirst-pass slug photoresponsive-oligonucleotide-systems-for-drug-delivery
Additionally the applications that have emerged in recent years are discussed, including gene regulation, drug delivery and materials design.
Source:
application scope summarysupports
Emerging applications discussed in the review include gene regulation, drug delivery, and materials design.
Source:
Comparisons
Source-stated alternatives
The abstract does not name alternative delivery-control strategies.
Source:
The abstract does not name alternative delivery-control strategies.
Source-backed strengths
light-based control is non-invasive and offers spatiotemporal precision
Source:
light-based control is non-invasive and offers spatiotemporal precision
Compared with mMORp
photoresponsive oligonucleotide systems for drug delivery and mMORp address a similar problem space.
Shared frame: same top-level item type; same primary input modality: light
Compared with optogenetic probes
photoresponsive oligonucleotide systems for drug delivery and optogenetic probes address a similar problem space.
Shared frame: same top-level item type; same primary input modality: light
Compared with organoid fusion
photoresponsive oligonucleotide systems for drug delivery and organoid fusion address a similar problem space.
Shared frame: same top-level item type; same primary input modality: light
Ranked Citations
- 1.