Source 1review2021Biological Psychiatry
Toolkit/pupillometry
pupillometry
Taxonomy: Technique Branch / Method. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
novel magnetic resonance imaging applications combined with pupillometry have opened the way to evaluate LC activity in vivo
Usefulness & Problems
Why this is useful
Pupillometry is named as part of a combined approach for evaluating LC activity in vivo. In the abstract, it functions as a physiological measurement component rather than a manipulation tool.; in vivo evaluation of LC activity when combined with MRI
Source:
Pupillometry is named as part of a combined approach for evaluating LC activity in vivo. In the abstract, it functions as a physiological measurement component rather than a manipulation tool.
Source:
in vivo evaluation of LC activity when combined with MRI
Problem solved
Within this review, pupillometry contributes to the challenge of assessing LC activity in vivo. It is presented as part of a newer measurement toolkit for LC research.; contributes to in vivo assessment of LC activity
Source:
Within this review, pupillometry contributes to the challenge of assessing LC activity in vivo. It is presented as part of a newer measurement toolkit for LC research.
Source:
contributes to in vivo assessment of LC activity
Problem links
contributes to in vivo assessment of LC activity
LiteratureWithin this review, pupillometry contributes to the challenge of assessing LC activity in vivo. It is presented as part of a newer measurement toolkit for LC research.
Source:
Within this review, pupillometry contributes to the challenge of assessing LC activity in vivo. It is presented as part of a newer measurement toolkit for LC research.
Taxonomy & Function
Primary hierarchy
Technique Branch
Method: A concrete measurement method used to characterize an engineered system.
Mechanisms
physiological measurementTechniques
Functional AssayTarget processes
No target processes tagged yet.
Input: Magnetic
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: sensor
The abstract supports its use in combination with MRI applications. It does not provide standalone protocol or hardware details.; used in combination with MRI according to the abstract; review abstract does not specify instrumentation or analysis details
The abstract does not state that pupillometry alone resolves LC projection specificity or causality. It also does not describe disease-specific diagnostic performance.; the abstract only supports use in combination with MRI, not standalone performance
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Novel magnetic resonance imaging applications combined with pupillometry have opened the way to evaluate locus coeruleus activity in vivo.
novel magnetic resonance imaging applications combined with pupillometry have opened the way to evaluate LC activity in vivo
DREADDs and optogenetics helped redefine the locus coeruleus from a homogeneous structure to a functionally heterogeneous system.
novel research tools are now available that have helped redefine the LC system, moving away from the traditional view of LC as a homogeneous structure that exerts a uniform influence on neural activity. Indeed, innovative techniques such as DREADDs (designer receptors exclusively activated by designer drugs) and optogenetics have demonstrated the functional heterogeneity of LC
Approval Evidence
1 source1 linked approval claimfirst-pass slug pupillometry
novel magnetic resonance imaging applications combined with pupillometry have opened the way to evaluate LC activity in vivo
Source:
measurement capabilitysupports
Novel magnetic resonance imaging applications combined with pupillometry have opened the way to evaluate locus coeruleus activity in vivo.
novel magnetic resonance imaging applications combined with pupillometry have opened the way to evaluate LC activity in vivo
Source:
Comparisons
Source-stated alternatives
The abstract mentions DREADDs and optogenetics as alternative tool classes for LC research, but these are perturbation methods rather than in vivo measurement readouts.
Source:
The abstract mentions DREADDs and optogenetics as alternative tool classes for LC research, but these are perturbation methods rather than in vivo measurement readouts.
Source-backed strengths
named directly as part of a novel in vivo LC evaluation approach
Source:
named directly as part of a novel in vivo LC evaluation approach
Compared with chemogenetics
The abstract mentions DREADDs and optogenetics as alternative tool classes for LC research, but these are perturbation methods rather than in vivo measurement readouts.
Shared frame: source-stated alternative in extracted literature
Strengths here: named directly as part of a novel in vivo LC evaluation approach.
Relative tradeoffs: the abstract only supports use in combination with MRI, not standalone performance.
Source:
The abstract mentions DREADDs and optogenetics as alternative tool classes for LC research, but these are perturbation methods rather than in vivo measurement readouts.
Compared with designer GPCRs
The abstract mentions DREADDs and optogenetics as alternative tool classes for LC research, but these are perturbation methods rather than in vivo measurement readouts.
Shared frame: source-stated alternative in extracted literature
Strengths here: named directly as part of a novel in vivo LC evaluation approach.
Relative tradeoffs: the abstract only supports use in combination with MRI, not standalone performance.
Source:
The abstract mentions DREADDs and optogenetics as alternative tool classes for LC research, but these are perturbation methods rather than in vivo measurement readouts.
Compared with optogenetic functional interrogation
The abstract mentions DREADDs and optogenetics as alternative tool classes for LC research, but these are perturbation methods rather than in vivo measurement readouts.
Shared frame: source-stated alternative in extracted literature
Strengths here: named directly as part of a novel in vivo LC evaluation approach.
Relative tradeoffs: the abstract only supports use in combination with MRI, not standalone performance.
Source:
The abstract mentions DREADDs and optogenetics as alternative tool classes for LC research, but these are perturbation methods rather than in vivo measurement readouts.
Compared with optogenetic membrane potential perturbation
The abstract mentions DREADDs and optogenetics as alternative tool classes for LC research, but these are perturbation methods rather than in vivo measurement readouts.
Shared frame: source-stated alternative in extracted literature
Strengths here: named directly as part of a novel in vivo LC evaluation approach.
Relative tradeoffs: the abstract only supports use in combination with MRI, not standalone performance.
Source:
The abstract mentions DREADDs and optogenetics as alternative tool classes for LC research, but these are perturbation methods rather than in vivo measurement readouts.
Ranked Citations
- 1.