Source 1review2009Chemical Society Reviews
Toolkit/self-assembled monolayers for dynamic cell adhesion control
self-assembled monolayers for dynamic cell adhesion control
Also known as: SAM-modified surfaces, SAMs
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Dynamic control over SAMs for cell adhesion provides an additional handle to direct and study the attachment of cells to surfaces... recent developments in cell adhesion of mammalian cells to SAM-modified surfaces, the physical properties of which can be controlled by an external stimulus, e.g. by light, electrochemistry, etc., are discussed.
Usefulness & Problems
Why this is useful
This platform uses self-assembled monolayer-modified surfaces whose physical properties can be changed by an external stimulus to control mammalian cell adhesion. The review frames it as a way to direct and study attachment at artificial interfaces.; dynamic control of mammalian cell adhesion at artificial interfaces; spatial control of cell-surface interactions; cell-based screening device design; studying cell attachment and spreading on patterned surfaces
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This platform uses self-assembled monolayer-modified surfaces whose physical properties can be changed by an external stimulus to control mammalian cell adhesion. The review frames it as a way to direct and study attachment at artificial interfaces.
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dynamic control of mammalian cell adhesion at artificial interfaces
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spatial control of cell-surface interactions
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cell-based screening device design
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studying cell attachment and spreading on patterned surfaces
Problem solved
It addresses the need for dynamic and potentially spatial control over cell-surface interactions in tissue engineering, cell biology, immunology, and screening devices.; provides externally triggered control over interactions between cells and artificial surfaces; enables directed study of cell attachment to engineered surfaces
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It addresses the need for dynamic and potentially spatial control over cell-surface interactions in tissue engineering, cell biology, immunology, and screening devices.
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provides externally triggered control over interactions between cells and artificial surfaces
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enables directed study of cell attachment to engineered surfaces
Problem links
enables directed study of cell attachment to engineered surfaces
LiteratureIt addresses the need for dynamic and potentially spatial control over cell-surface interactions in tissue engineering, cell biology, immunology, and screening devices.
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It addresses the need for dynamic and potentially spatial control over cell-surface interactions in tissue engineering, cell biology, immunology, and screening devices.
provides externally triggered control over interactions between cells and artificial surfaces
LiteratureIt addresses the need for dynamic and potentially spatial control over cell-surface interactions in tissue engineering, cell biology, immunology, and screening devices.
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It addresses the need for dynamic and potentially spatial control over cell-surface interactions in tissue engineering, cell biology, immunology, and screening devices.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A reusable architecture pattern for arranging parts into an engineered system.
Mechanisms
electrochemical modulation of cell-adhesive surfaceslight-triggered modulation of cell-adhesive surfacesstimulus-responsive surface property switchingTarget processes
recombinationselectionInput: Light
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationimplementation constraint: spectral hardware requirementoperating role: regulator
Implementation requires a SAM-modified surface and a compatible external trigger such as light or electrochemistry. The abstract specifically discusses mammalian-cell adhesion on these engineered interfaces.; requires SAM-modified surfaces; requires an external stimulus to modulate surface properties
The abstract indicates that truly reversible control of cell adhesion on substrates remains immature, so the approach does not yet fully solve robust reversible adhesion control.; reversible control of cell adhesion onto substrates is still in its infancy
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Dynamic control over cell-surface interactions holds promise for tissue engineering, medicine, cell biology, and immunology.
Improved spatial control over cell-surface interaction is potentially useful for designing cell-based screening devices and for studying cell spreading from predetermined patterns to screen drug-candidate cytotoxicity.
Reversible control of cell adhesion onto substrates is still in its infancy.
Externally stimulus-responsive SAM-modified surfaces are being developed to dynamically control mammalian cell adhesion.
Approval Evidence
1 source4 linked approval claimsfirst-pass slug self-assembled-monolayers-for-dynamic-cell-adhesion-control
Dynamic control over SAMs for cell adhesion provides an additional handle to direct and study the attachment of cells to surfaces... recent developments in cell adhesion of mammalian cells to SAM-modified surfaces, the physical properties of which can be controlled by an external stimulus, e.g. by light, electrochemistry, etc., are discussed.
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application potentialsupports
Dynamic control over cell-surface interactions holds promise for tissue engineering, medicine, cell biology, and immunology.
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application potentialsupports
Improved spatial control over cell-surface interaction is potentially useful for designing cell-based screening devices and for studying cell spreading from predetermined patterns to screen drug-candidate cytotoxicity.
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maturity assessmentsupports
Reversible control of cell adhesion onto substrates is still in its infancy.
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review scope summarysupports
Externally stimulus-responsive SAM-modified surfaces are being developed to dynamically control mammalian cell adhesion.
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Comparisons
Source-stated alternatives
The abstract only explicitly names externally controlled SAM-based surfaces and does not provide a direct benchmark against a specific alternative platform.
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The abstract only explicitly names externally controlled SAM-based surfaces and does not provide a direct benchmark against a specific alternative platform.
Source-backed strengths
supports external-stimulus control such as light or electrochemistry; offers an additional handle for directing and studying cell attachment; potentially useful for spatially controlled screening formats
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supports external-stimulus control such as light or electrochemistry
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offers an additional handle for directing and studying cell attachment
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potentially useful for spatially controlled screening formats
Compared with CfRhPDE1
self-assembled monolayers for dynamic cell adhesion control and CfRhPDE1 address a similar problem space because they share recombination, selection.
Shared frame: same top-level item type; shared target processes: recombination, selection; same primary input modality: light
Compared with CheRiff
self-assembled monolayers for dynamic cell adhesion control and CheRiff address a similar problem space because they share recombination, selection.
Shared frame: same top-level item type; shared target processes: recombination, selection; same primary input modality: light
Compared with luciferin-luciferase pair
self-assembled monolayers for dynamic cell adhesion control and luciferin-luciferase pair address a similar problem space because they share recombination, selection.
Shared frame: same top-level item type; shared target processes: recombination, selection; same primary input modality: light
Ranked Citations
- 1.