Source 1primary paper2015Journal of Biological Engineering
Toolkit/synthetic small molecule-responsive RNA devices
synthetic small molecule-responsive RNA devices
Taxonomy: Mechanism Branch / Component. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Synthetic small molecule-responsive RNA devices are engineered RNA elements reported to regulate the mammalian cell cycle. In the cited 2015 study, they are presented as a modular platform for dynamic and multi-output control in mammalian cells.
Usefulness & Problems
Why this is useful
These RNA devices are useful as a synthetic biology platform for modular control of mammalian cellular behavior using small-molecule inputs. The cited study specifically positions them as tools for dynamic, multi-output regulation in mammalian cells.
Problem solved
The reported problem addressed is how to achieve synthetic control over the mammalian cell cycle using engineered RNA-based regulators. The paper states that this was the first use of synthetic RNA devices for mammalian cell-cycle control.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Component: A low-level RNA part used inside a larger architecture that realizes a mechanism.
Mechanisms
small-molecule-responsive rna regulationTechniques
No technique tags yet.
Target processes
No target processes tagged yet.
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: actuator
The available evidence indicates that these are synthetic RNA devices designed for mammalian cells and responsive to small molecules. However, the supplied material does not describe construct design, delivery method, expression context, or any required cofactors.
The provided evidence does not specify the exact RNA architectures, small-molecule ligands, target genes, or quantitative performance metrics. Independent replication and validation outside the cited study are not documented in the supplied material.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
The paper states that this is the first time synthetic RNA devices have been used to control the mammalian cell cycle.
To our knowledge, this is the first time synthetic RNA devices have been used to control the mammalian cell cycle.
The paper states that this is the first time synthetic RNA devices have been used to control the mammalian cell cycle.
To our knowledge, this is the first time synthetic RNA devices have been used to control the mammalian cell cycle.
The paper states that this is the first time synthetic RNA devices have been used to control the mammalian cell cycle.
To our knowledge, this is the first time synthetic RNA devices have been used to control the mammalian cell cycle.
The paper states that this is the first time synthetic RNA devices have been used to control the mammalian cell cycle.
To our knowledge, this is the first time synthetic RNA devices have been used to control the mammalian cell cycle.
The paper states that this is the first time synthetic RNA devices have been used to control the mammalian cell cycle.
To our knowledge, this is the first time synthetic RNA devices have been used to control the mammalian cell cycle.
The paper states that this is the first time synthetic RNA devices have been used to control the mammalian cell cycle.
To our knowledge, this is the first time synthetic RNA devices have been used to control the mammalian cell cycle.
The paper states that this is the first time synthetic RNA devices have been used to control the mammalian cell cycle.
To our knowledge, this is the first time synthetic RNA devices have been used to control the mammalian cell cycle.
The RNA platform is presented as a general class of synthetic biology tools for modular, dynamic, and multi-output control over mammalian cells.
This RNA platform represents a general class of synthetic biology tools for modular, dynamic, and multi-output control over mammalian cells.
The RNA platform is presented as a general class of synthetic biology tools for modular, dynamic, and multi-output control over mammalian cells.
This RNA platform represents a general class of synthetic biology tools for modular, dynamic, and multi-output control over mammalian cells.
The RNA platform is presented as a general class of synthetic biology tools for modular, dynamic, and multi-output control over mammalian cells.
This RNA platform represents a general class of synthetic biology tools for modular, dynamic, and multi-output control over mammalian cells.
The RNA platform is presented as a general class of synthetic biology tools for modular, dynamic, and multi-output control over mammalian cells.
This RNA platform represents a general class of synthetic biology tools for modular, dynamic, and multi-output control over mammalian cells.
The RNA platform is presented as a general class of synthetic biology tools for modular, dynamic, and multi-output control over mammalian cells.
This RNA platform represents a general class of synthetic biology tools for modular, dynamic, and multi-output control over mammalian cells.
The RNA platform is presented as a general class of synthetic biology tools for modular, dynamic, and multi-output control over mammalian cells.
This RNA platform represents a general class of synthetic biology tools for modular, dynamic, and multi-output control over mammalian cells.
The RNA platform is presented as a general class of synthetic biology tools for modular, dynamic, and multi-output control over mammalian cells.
This RNA platform represents a general class of synthetic biology tools for modular, dynamic, and multi-output control over mammalian cells.
Approval Evidence
1 source1 linked approval claimfirst-pass slug synthetic-small-molecule-responsive-rna-devices
Engineering dynamic cell cycle control with synthetic small molecule-responsive RNA devices
Source:
first usesupports
The paper states that this is the first time synthetic RNA devices have been used to control the mammalian cell cycle.
To our knowledge, this is the first time synthetic RNA devices have been used to control the mammalian cell cycle.
Source:
Comparisons
Source-backed strengths
The main reported strengths are modularity, dynamic regulation, and the ability to support multiple outputs in mammalian cells. The study also claims a first demonstration of using synthetic RNA devices to control the mammalian cell cycle.
Compared with RNA aptamer
synthetic small molecule-responsive RNA devices and RNA aptamer address a similar problem space.
Shared frame: same top-level item type
Strengths here: looks easier to implement in practice.
Compared with RNA platform
synthetic small molecule-responsive RNA devices and RNA platform address a similar problem space.
Shared frame: same top-level item type
Compared with toehold-gated guide RNA
synthetic small molecule-responsive RNA devices and toehold-gated guide RNA address a similar problem space.
Shared frame: same top-level item type
Ranked Citations
- 1.