Toolkit Items

Browse the toolkit beneath workflows. The mechanism branch runs mechanism -> architecture -> component, while the technique branch runs from high-level approaches down to concrete methods.

2 items matching 1 filter

Mechanism Branch

Layer 1

Mechanisms

Top-level concepts: biophysical action modes such as heterodimerization, photocleavage, or RNA binding.

Layer 2

Architectures

Arrangements that realize or deploy mechanisms, including switches, construct patterns, and delivery strategies.

Layer 3

Components

Low-level parts and sequence-defined elements used inside architectures, including protein domains and RNA elements.

Technique Branch

Layer 1

Approaches

High-level engineering practices such as computational design, directed evolution, sequence verification, and functional assay.

Layer 2

Methods

Concrete methods used to design, build, verify, or characterize engineered systems.

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Opto-controlled C9orf72 poly-PR

Construct Pattern

Opto-controlled C9orf72 poly-PR is a light-responsive cellular construct used to induce poly-PR condensation and aggregation in cultured cells with spatial and temporal control. In the reported 2024 study, it generated anisotropic poly-PR condensates associated with nuclear TDP-43 granulation and pathology-relevant phenotypes.

CFBacMamMusHumTxRep
Ev 28Rep 9Pr 59

ligand-protected gold nanoparticles

Construct Pattern

Especially attractive are ligand-protected gold nanoparticles, which have been extensively used over the last decade as building blocks in constructing superlattices or dynamic aggregates, under the effect of an applied stimulus.

CFBacMamMusHumTxRep
Ev 10Rep 9Pr 71
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