Opto-controlled C9orf72 poly-PR
Construct PatternOpto-controlled C9orf72 poly-PR is a light-responsive cellular construct used to induce poly-PR condensation and aggregation in cultured cells with spatial and temporal control. In the reported 2024 study, it generated anisotropic poly-PR condensates associated with nuclear TDP-43 granulation and pathology-relevant phenotypes.