Fus1
Protein DomainFus1 is a formin protein domain context in which an intrinsically disordered region is reported to drive condensation of the fusion focus. This condensation activity is essential for cell-cell fusion.
Browse the toolkit beneath workflows. The mechanism branch runs mechanism -> architecture -> component, while the technique branch runs from high-level approaches down to concrete methods.
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Mechanism Branch
Layer 1
Mechanisms
Top-level concepts: biophysical action modes such as heterodimerization, photocleavage, or RNA binding.
Layer 2
Architectures
Arrangements that realize or deploy mechanisms, including switches, construct patterns, and delivery strategies.
Layer 3
Components
Low-level parts and sequence-defined elements used inside architectures, including protein domains and RNA elements.
Technique Branch
Layer 1
Approaches
High-level engineering practices such as computational design, directed evolution, sequence verification, and functional assay.
Layer 2
Methods
Concrete methods used to design, build, verify, or characterize engineered systems.
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Fus1 is a formin protein domain context in which an intrinsically disordered region is reported to drive condensation of the fusion focus. This condensation activity is essential for cell-cell fusion.
The SMN tudor domain is a globular protein domain from SMN that is sufficient for dimerization-induced condensation in vivo. Its condensate-forming activity requires binding to dimethylarginine, supporting its use as a chemical-input interaction module for specifying membraneless organelle assembly.