Toolkit Items

Browse the toolkit beneath workflows. The mechanism branch runs mechanism -> architecture -> component, while the technique branch runs from high-level approaches down to concrete methods.

7 items matching 1 filter

Mechanism Branch

Layer 1

Mechanisms

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Top-level concepts: biophysical action modes such as heterodimerization, photocleavage, or RNA binding.

Layer 2

Architectures

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Arrangements that realize or deploy mechanisms, including switches, construct patterns, and delivery strategies.

Layer 3

Components

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Low-level parts and sequence-defined elements used inside architectures, including protein domains and RNA elements.

Technique Branch

Layer 1

Approaches

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High-level engineering practices such as computational design, directed evolution, sequence verification, and functional assay.

Layer 2

Methods

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Concrete methods used to design, build, verify, or characterize engineered systems.

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light-triggered cargo release

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AS1411 aptamer-modified cell membrane biomimetic core-shell system

Delivery Strategy
Since 2023cell membrane camouflagelight-triggered cargo releaselight-triggered lysosomal escapereactive oxygen species generationtumor targeting via as1411 aptamer modification

The AS1411 aptamer-modified cell membrane biomimetic core-shell system is a light-augmented delivery harness for CRISPR-Cas9 plasmid cargo (pCas9). It consists of a cell membrane-camouflaged shell modified with AS1411 aptamers and photosensitizers to promote tumor targeting, reactive oxygen species-mediated lysosomal escape, and light-controllable pCas9 release for enhanced gene editing.

CFBacMamMusHumTxRep
Ev 28Rep 9Pr 59

azobenzene-cyclodextrin host-guest siRNA release module

Construct Pattern
Since 2017host-guest associationlight-triggered cargo releasephotoisomerizationupconversion-mediated phototriggering

The azobenzene-cyclodextrin host-guest siRNA release module is a light-responsive siRNA carrier motif built on azobenzene–cyclodextrin host-guest association. In the reported system, near-infrared irradiation is converted by upconversion nanoparticles into UV emission that induces azobenzene photoisomerization and controlled siRNA release.

CFBacMamMusHumTxRep
Ev 28Rep 9Pr 59

layer-by-layer

Engineering Method
light-triggered cargo release

A special focus is put on systems activated by wavelengths less harmful for living organisms ... as well as on different preparation techniques, namely liposomes, self-assembly, layer-by-layer, and interfacial polymerization.

CFBacMamMusHumTxRep

light-responsive nanocarriers

Delivery Strategy
light-triggered cargo releaseComputational Design

The synthesis of light-responsive nanocarriers (LRNs) with a variety of surface functional groups and/or ligands has been intensively explored for space-temporal controlled cargo release. LRNs trigger the release of cargo by a light stimulus.

CFBacMamMusHumTxRep

NaYF4:Yb/Tm/Er upconversion nanoparticle

Delivery Strategy
azobenzene photoisomerizationlight-triggered cargo releaseupconversion-mediated nir-to-uv phototransduction

The NaYF4:Yb/Tm/Er upconversion nanoparticle is a light-responsive siRNA delivery nanocarrier reported for near-infrared-controlled gene silencing. In the described system, NaYF4:Yb/Tm/Er upconversion converts NIR irradiation into UV emission that induces azobenzene photoisomerization and triggers controlled siRNA release.

CFBacMamMusHumTxRep
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