Toolkit Items

Here we report vibrational photochromism by engineering alkyne tagged diarylethene to realize photo-switchable SRS imaging.

The azobenzene-cyclodextrin host-guest siRNA release module is a light-responsive siRNA carrier motif built on azobenzene–cyclodextrin host-guest association. In the reported system, near-infrared irradiation is converted by upconversion nanoparticles into UV emission that induces azobenzene photoisomerization and controlled siRNA release.

Here we report vibrational photochromism by engineering alkyne tagged diarylethene to realize photo-switchable SRS imaging.

This review describes polymers and surfaces that have been prepared recently that incorporate azobenzene groups, and some of the interesting physical and chemical properties that can be switched reversibly as a result.

Developments in azobenzene and hemithioindigo based photolipids are discussed, underscoring their utility in biomedical and biomaterial science applications due to their unique photophysical properties.

The supplied web research summary states that the review explicitly centers on hybrids with azobenzene motifs and carbon nanomaterials, especially carbon nanotubes.

Developments in azobenzene and hemithioindigo based photolipids are discussed, underscoring their utility in biomedical and biomaterial science applications due to their unique photophysical properties.

Light-activatable nanoplatforms are light-responsive nano-regulators designed to modulate cellular events. The reviewed systems use light input, including UV-Vis-triggered photocleavage and photoisomerization, to control biological interventions across multiple application areas.

Thus, light responsive hydrogels are of particular interests to researchers in developing accurate and controlled drug delivery systems. Light responsive hydrogels are obtained by incorporating photosensitive moieties into their polymeric structures.

Light-responsive nano-regulators are light-activatable nanoplatforms used to manipulate cellular functions with high spatiotemporal precision. The cited 2019 review describes their application to neuromodulation, stem cell monitoring, immunomanipulation, cancer therapy, and other biological target interventions.

small molecule inhibitors have been developed in which their OFF/ON therapeutic activity can be toggled using light

Photoisomerization is a light-responsive engineering method described in a 2019 review of nano-regulators for biological modulation. In that review, it is presented as a UV-Vis light-triggered approach used within light-activatable nanoplatforms to control cellular events.

The design of photoactive complex coacervate protocells in laboratory settings by utilizing photochromic molecules such as azobenzene and diarylethene is further discussed.

Molecular photoswitches are a class of chemical structures that can readily isomerize between distinct geometries upon irradiation with light. Molecular photoswitches are utilized to control protein structure and function with temporal and spatial precision. In this review, we summarize the recent progress in the development of azobenzene-based molecular photoswitches and their applications in the photocontrol of protein structure and function.

Photopharmacology enables precise spatial and temporal drug control of receptors by light using modified drug molecules incorporating chemical photoswitches, especially azobenzenes.

An azobenzene photoswitch incorporated into the peptide backbone allows reversible switching between a trans photostationary state devoid of secondary structure, and a cis photostationary state possessing a well-defined antiparallel β-strand geometry.

Donor-acceptor Stenhouse adduct (DASA) photoswitches have gained a lot of attention since their discovery in 2014. Their negative photochromism, visible light absorbance, synthetic tunability, and the large property changes between their photoisomers make them attractive candidates over other commonly used photoswitches for use in materials with responsive or adaptive properties.

Allosteric and dualsteric photoswitchable ligands, the latter targeting both orthosteric and allosteric sites, are being developed.

These include (2) nanokeys, which are untethered (freely diffusing) photoswitchable ligands

These include (3) nanotweezers, which are photoswitchable crosslinkers.

We explore photoswitchable diacylglycerophospholipids, termed 'photolipids', which permit precise, reversible modifications of membrane properties via light-induced isomerization.

LD50 values for gramicidin S and photoisomeric forms of its photoswitchable diarylethene-containing analogs were determined using mice.

The use of photoswitchable ligand to control the protein functionalities and related downstream effects in an on-off manner is an active research area in photopharmacology and medicinal chemistry.

Photoswitchable lipids dissolved or reformed the domains.

In this study, a novel light-driven photoswitchable peptide-based biosensor, modelled on the nNOS β-finger, is used to detect and control its interaction with α-syntrophin.

Photoswitchable peptides have been recognized for many years; however, their functional implementation in biological systems has only recently been achieved... These exciting proof-of-principle studies highlight the tremendous potential of photocontrollable peptides as optochemical tools for chemical biology and biomedicine.

Basic approaches and considerations for the structure-guided design of photoswitchable ligands are discussed.

Such compounds are designed in a modular fashion, combining a known ligand of the target protein and a photochromic group, as well as an additional electrophilic group for tethered ligands.

The cis- and trans-isomers of one of our peptidomimetics, termed TOP271, exhibit a four-fold difference in NPR-A mediated cGMP synthesis in vitro.

Ziapin2, a membrane-integrating azobenzene derivative, undergoes light-driven trans-cis isomerization that alters membrane capacitance (Cm).