Browse the toolkit beneath workflows. The mechanism branch runs mechanism -> architecture -> component, while the technique branch runs from high-level approaches down to concrete methods.
14 items matching 1 filter
Mechanism Branch
Layer 1
Mechanisms
Top-level concepts: biophysical action modes such as heterodimerization, photocleavage, or RNA binding.
Layer 2
Architectures
Arrangements that realize or deploy mechanisms, including switches, construct patterns, and delivery strategies.
Layer 3
Components
Low-level parts and sequence-defined elements used inside architectures, including protein domains and RNA elements.
Technique Branch
Layer 1
Approaches
High-level engineering practices such as computational design, directed evolution, sequence verification, and functional assay.
Layer 2
Methods
Concrete methods used to design, build, verify, or characterize engineered systems.
Showing 1-14 of 14
Subsequently, we delve into cutting-edge applications of nanoparticles to enhance immune protection, including mosaic and cocktail nanoparticle vaccines, surface-modified targeting strategies, and the integration of mRNA technology with virus-like particles (VLPs).
Self-assembling peptidic hydrogels are uniquely suited for this setting because their molecular programmability, supramolecular order, and tissue-conforming mechanics enable both precision drug delivery and immune modulation.
The simple self-assembly model is a computational method for active mixtures of microtubules and molecular motors. It captures the extensile-to-contractile transition by representing competition between nematic and polar aligning interactions that drive formation of bundles or asters.
Codon-optimized full-length Cap and putative NLS-deleted dCap (residues 1-36) were expressed in Escherichia coli. Full-length Cap self-assembled into 13-17 nm icosahedral VLP, structurally consistent with native virions.
The purified protein self-assembled into uniform 25 nm virus-like particles (VLPs).
Through genetic engineering, antigenic peptides up to 91 amino acids in length can be densely displayed at the N-terminal β-hairpin (AB loop) of the coat protein.
This review showcases the implementation of function into self-assembled cages and devises strategies to selectively form heteroleptic structures.
This review provides a comprehensive overview of recent advances in the supramolecular organisation and hierarchical self-assembly of organo-functionalised hybrid polyoxometalates (hereafter referred to as hybrid POMs), and their emerging role as multi-functional building blocks in the construction of new nanomaterials.
making use of virtually all types of polymer constructs, from self-assembled structures (micelles, vesicles) ... We will also highlight some examples of responsive systems used for therapeutic applications, including smart drug delivery systems (micelles, vesicles, dendrimers...)
making use of virtually all types of polymer constructs, from self-assembled structures (micelles, vesicles) ... including smart drug delivery systems (micelles, vesicles, dendrimers...)
utilizing therapeutic or imaging agents-loaded stimuli-responsive block copolymer assemblies that are responsive to tumor internal microenvironments (pH, redox, enzyme, and temperature, etc.) or external stimuli (light and electromagnetic field, etc.) have emerged to be an important solution to improve therapeutic efficacy and imaging sensitivity through rationally designing as well as self-assembling approaches
We discuss first examples resulting from a combination of both principles, namely multicomponent multifunctional host-guest complexes, and their potential in application in areas such as sensing, catalysis, and photo-redox systems.
The coat protein of the MS2 self-assembles into virus-like particles (VLPs) with a diameter of 26 nm. These VLPs are devoid of the phage genome yet are efficiently recognized by the immune system, eliciting robust humoral and cellular immune responses. The structural characteristics of VLPs position them as a promising platform for the development of vaccines and diagnostic tools.
Niosomes (NIOs), a class of nanovesicular drug delivery system... resulting from the self-assembly of non-ionic surfactants (with or without cholesterol) in aqueous media.