Mechanisms

A stimulus triggers a structural change that exposes a previously hidden functional element. Current coverage includes 23 architectures and 25 components. Representative components include AsLOV2, Avena sativa LOV2 domain variants, and Avena sativa phototropin LOV2 domain.

23 architectures · 25 components

A stimulus triggers targeted degradation of a protein via the proteasome or other pathways. Current coverage includes 18 architectures and 10 components. Representative components include Arabidopsis CRY2, LOV2 domain-based optogenetic tool, and LOVdeg tag.

18 architectures · 10 components

A protein binds DNA in a stimulus-dependent manner to regulate gene expression. Current coverage includes 2 architectures and 1 component. Representative components include AsLOV2-Jα.

2 architectures · 1 components

Two different proteins are brought together by a stimulus, enabling recruitment or complex formation. Current coverage includes 70 architectures and 30 components. Representative components include Aer PAS domain, Arabidopsis thaliana cryptochrome 2, and CIB1 N-terminal CRY2-binding region.

70 architectures · 30 components

A protein is recruited to a membrane surface (e.g. plasma membrane) by a stimulus. Current coverage includes 13 architectures and 3 components. Representative components include light activated nuclear shuttle (LANS) domain, light-inducible nuclear localization signal, and light-inducible nuclear localization signals.

13 architectures · 3 components

A protein self-associates into multimers upon stimulation, enabling clustering or activation. Current coverage includes 27 architectures and 9 components. Representative components include Arabidopsis CRY2, Arabidopsis CRY2 photosensory domain, and BcLOV4 photoreceptor.

27 architectures · 9 components

Light breaks a covalent bond, irreversibly releasing a caged peptide or domain. Current coverage includes 22 architectures and 14 components. Representative components include 2A sequence, HeFSpCas9, and LHCII N-terminal domain.

22 architectures · 14 components

A protein or RNA element binds RNA to control translation or stability. Current coverage includes 9 architectures and 3 components. Representative components include RNA aptamer, caged guide RNA, and hypoxanthine switch.

9 architectures · 3 components

Post-transcriptional regulation of mRNA translation rate or efficiency. Current coverage includes 16 architectures and 9 components. Representative components include 2A sequence, LOVdeg tag, and human opsins.

16 architectures · 9 components