CARmacrophages (CAR-M) ... not only phagocytose tumor cells and present antigens but also remodel the immunosuppressive tumor microenvironment
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Mechanism Concept
phagocytosis
A mechanism-level grouping derived from the current toolkit evidence. Current coverage includes 6 architectures and 0 components. Across those tools, the main enabled capabilities are signaling, manufacturing, and recombination.
6 total items6 architectures0 components
Main enabled capabilities: signaling, manufacturing, recombination.
Architectures
6 of 6chimeric antigen receptor-macrophages (CAR-MΦ)
dual-effector regimens (CAR-NK+ CAR-MΦ)
Engineering chimeric antigen receptors (CARs) to endow macrophages with anti-tumor capacities demonstrated encouraging efficacy, particularly in enhancing tumor-targeted phagocytosis. Furthermore, CAR macrophages (CAR-Ms) orchestrate adaptive immunity through secreting pro-inflammatory cytokines and presenting tumor antigens, thereby activating cytotoxic T lymphocyte responses.
sophisticated logic-gated circuits
scalable induced pluripotent stem cell (iPSC)-derived platforms